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Opioids Loperamide (Immodium) Megathread: We have now lost at least 2 of our own from Lope

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Ive been addicted to pills for 15 years and I have never heard of immodium ad to help with w/d symtoms . Crazy doesnt sound like smartes idea but if your wd bad enough I would probably try to bc as we all know pills are cool till we run out. My doc recently prescribed Chantix so I could quit smoking and im on day 5 with no narcotics and doing good at cleaning up. Im shocked it really helps though .
 
I think my friend has read about everything he could find on lopramide and other compounds related to pgp. it WILL help withdrawls phyically by itself no doubt definatly helps. Now my friend when he cant get any opiates and is in withdrawl and looking for a mild buzz will take his effexor(precscriped 150 mg /day) capsule up about 7 grams of pepper and dose alll at once and there is a definate buzz he tells me he hasnt tryed with prilosec but will next time needed but this combo leaves him feeling well for at least 24 hours which is a god send in withdrawls when his connect says hell be over in 45 and then has phone off ever since stressful he tells me lol. jus my two cents on what ive heard :)

Ussualy he uses 42 count boxes at a time he tells me
 
sry fpor edit again jus figured i shuld say effexor is a slight pgp inhibitor as are a few of the othre newer anti depressants. as is piperine(sp) which is found in pepper in contents of 5-9%
 
ok so im on day 13.5 on my poppy/oxy/dialudid addiction and have been using loperamide. now i just went 2.5 days without it and i started to feel like shit. worse then i was feeling on day 6-7 with the loperamide. is this my withdrawal being felt more now because no loperamide to mask it or is it loperamide withdrawal. 12-35mg a day for 11 days, will that cause any loperamide withdrawal. i cant seem to find any good answers on loperamide precipitated withdrawal. and it was really shit. could sleep or stay still and legs fuckin killed, its confusing.
 
Loperamide can definitely cause you to withdrawal when you stop using. Ive been trying to stop using lope for awhile now and im stuck. Im doing a taper but once you go to low it seems to not work much at all. Maybe because its not enough to cross the blood brain barrier but im not sure. I'm just going to stabilize at where im at and then try tapering agian. I used it to come off methadone successfully but this is almost as much a problem
 
I am currently on day 3 of wd but using loperamide to ease wd, along with dxm, gabapentin, and xanaflex. Some mild achiness and a few chills here and there are my only symptoms to report. This is cake, almost too easy.

A little background: I am on percocet 10/325 4x day for chronic pain due to mva 7/4/2009 in which I broke my neck. I also have lower back issues, sciatica, congenital stenosis, etc. etc. The last 3 months my dr has brought me down to this from 6x daily, and wont listen to my complaints of being undertreated. I have run out of meds the last couple months and have taken leftover methadone to get through, stupid thing to do cause my tolly is through the roof with 50mg percocet barely taking the edge off the done wd. So in an effort to get my tolly down I am taking a break and using lope to get through and get tolly down. Its working amazingly well! When I started the lope I had just finished 7 days of 160-200mg percocet/day, dosing 40-50mg 4x daily. Before that was 7 days of 15mg methadone daily. The withdrawl waves from the dones have finally subsided, now to get through the perc wd. My first dose of lope was 48mg about 12 hrs after last dose of percs. 24 hrs later I took 40mg lope, and I just began day 3 with 32mg lope. Imo, the lope needs to be kept to a minimum and tapered asap so that lope wd is minimal at best when you jump. Lope has a long half life, somewhere around 10 hrs I believe, but correct me if I'm wrong please, and taking for many days continuously will cause a bit of a build up in your system and is why the lope wd isnt felt until about 48 hrs after your last dose, and sometimes longer depending upon how long it was taken. I will most likely taper a bit slower towards the end, unless I'm still feeling marvelous in a few days, then I may just jump.

Please tread lightly and dont try and use loperamide to get high. Afoaf just died from lope od last week, no joke. She did have issues in which her bbb was compromised, which is why she od. Lope is great to have to ease wd, no doubt. I am going to stock up on big bottles because it wont be long before you have to show your ID to get it or it becomes scheduled. Too many people abusing since the word got out about lope.

So thats my story and experience with loperamide, in a big nutshell. Hope this was informative and didnt drag on. Be safe and good luck.

P.S. if you are wondering how I picked the starting lope dose, I matched it by mg to the perc dose I was taking. I read that somewhere awhile back. Its helping for sure, like I said, this is too easy!
 
First off, your doc sounds pretty damn callous. You're clearly a legitimate pain sufferer and though we don't have Percocet here, you'd at the very least qualify for dhc, or tramadol. I've been stockpiling lope myself to help me get off of suboxone, along with kratom; I've no desire whatsoever to get high from the stuff, but I don't want to be using large quantities of it, so potentiating the lope is something I'm interested in. I've heard some theories to this end, ranging from the absurd to the simple.
Is it possible to get more from less from loperamide for the purpose of managing WD symptoms?
 
dopemegently said:
First off, your doc sounds pretty damn callous. You're clearly a legitimate pain sufferer and though we don't have Percocet here, you'd at the very least qualify for dhc, or tramadol. I've been stockpiling lope myself to help me get off of suboxone, along with kratom; I've no desire whatsoever to get high from the stuff, but I don't want to be using large quantities of it, so potentiating the lope is something I'm interested in. I've heard some theories to this end, ranging from the absurd to the simple.
Is it possible to get more from less from loperamide for the purpose of managing WD symptoms?
Click to expand...

yes. it seems the more you use, the more side-effects you get. same thing with suboxone, but different issues. i think extreme dehydration and constipation are the big ones. when i got off suboxone after using 3 years, i only needed 24mg of loperamide a day to kill most of the 8mg bupe withdrawal issues. that quickly dropped to 12mg in a couple weeks. i continued to drop 2mg or so every 3 days.

im sure i could have used more but i most definitely did not want to find myself addicted to loperamide, which i gather can physically be much worse.
 
Wow, that's actually pretty re-assuring to me. 24mgs of lope to eliminate bupe withdrawal is far less than I was worried I'd need. (I've heard people using 100's of mgs a day.) I'm on 12 mgs of bupe myself, and when I kick, it's either gonna be from 12 or from 8 mg)

I've heard that large doses of lope can cause severe constipation, possibly even a fecal impaction, pretty scary... Luckily, I've managed to obtain a box of Microlette micro enemas, they're for the direct treatment of severe constipation. I'm not sure how effective these things are, or the active ingredients, but it's basically a disposable IR syringe, and it's supposed to clear things out rapidly.
 
Yeah that is a large dose. Like 'I are Spectre' said you have to taper off. It actually acts on one of your opiate receptors. I believe the MU.
 
The Paxil works on the same level as my Zoloft, allowing the loperamide to cross the BBB and allows the user to experience mild to moderate opiate affects. It has a much higher impact then the gfj but the juice potentiates once the BBB has been crossed.
 
I'm on day 8 without my meds and doing great on loperamide, dxm, and neurontin. I had a small set back the weekend after Christmas but started the lope taper again on the 31st, taking 70mg. I read experience posts about alot of people having a hard time tapering and getting off the lope. I have easily been able to quickly taper down to only taking 18mg tonight. I'm guessing this is because of the dxm, which is known to reduce tollerance. Some doctors even prescribe mophine and other opiates to be compounded with dxm to help control tollerance. Its been proven to synergize with the opiate so that the patient requires a smaller dose to achieve theraputic effects. I cant leave out the neurontin which is known to help with withdrawl symptoms and I'm sure has helped enable me to quickly taper the lope without feeling any withdrawl while dropping my dose daily. Overall, days 1-4 were the worst, achiness and pain as complaints. Since then it has been pretty god and I've been able to care for my 2 year old the entire time. I would strongly suggest adding dxm to any loperamide taper. It certainly couldn't hurt.
 
I've been maintaining on 20-24mg lope daily, with 2.5 cups White Grapefruit Juice for PGP-inhibition to allow it to stay across the BBB.

It has been working fantastically for cravings, and has stabilized me since there really is no high to chase. Having said that, if you inhibit the PGP as much as possible, you can make doses like 20mg subjectively AND objectively powerful, and I actually feel a subtle, long-lasting opioid high from my dosage. So remember, don't exceed 24mg, but if you need it to work on your CNS, add cimetidine or WGFJuice to inhibit PGP instead of using the brute force technique of taking more than 12 pills of lope.
 
ErgicMergic said:
I've been maintaining on 20-24mg lope daily, with 2.5 cups White Grapefruit Juice for PGP-inhibition to allow it to stay across the BBB.

It has been working fantastically for cravings, and has stabilized me since there really is no high to chase. Having said that, if you inhibit the PGP as much as possible, you can make doses like 20mg subjectively AND objectively powerful, and I actually feel a subtle, long-lasting opioid high from my dosage. So remember, don't exceed 24mg, but if you need it to work on your CNS, add cimetidine or WGFJuice to inhibit PGP instead of using the brute force technique of taking more than 12 pills of lope.
Click to expand...

What dose of what opiate were you coming off before switching to the 24mg's of lope?
 
>_> ...... Damn it... oh well. Its still a relatively small risk, no alternative for me.
--
Ventricular Tachycardia Storm Due to Loperamide Abuse

Banas, Emerald; Rane, Meghan; Aggarwal, Aakash; Khorasani-zadeh, Arman; Kalamkar, Badal; Hemraj, Alisha
Collapse BoxAbstract
Introduction: This is a case of a 28 year old man with history of polysubstance abuse, chronic depression and small bowel obstruction secondary to Crohn's disease, who was initially brought to an outside facility after he collapsed at home and was found to be pulseless. He had several episodes of witnessed seizures. Upon EMS arrival, he was noted to be in ventricular tachycardia without pulses and converted to sinus rhythm after ACLS was performed. Review of history revealed that he had been taking amitriptyline 150-200 mg daily and up to 60 loperamide tablets daily for his Crohn's disease-related diarrhea. Physical exam was only remarkable for a heart rate that ranged from 45 to 160 bpm. Initial laboratories revealed normal cardiac injury panel and urine toxicology that was positive for tricyclic antidepressants. Amitriptyline level was 182 mcg/L, which was within the therapeutic range. Loperamide level was elevated at 130 ng/ml (50 ng/ml). There have been previous reported cases that euphoric effects may be achieved with high doses of loperamide, usually in association with alduterants like quinidine, which in this case was undetectable. Multiple EKGs done showed interventricular conduction delay with prolong QTc at 850 msec, ventricular tachycardia and ventricular fibrillation. He was defibrillated multiple times for recurrent monomorphic wide complex tachycardias with temporary resolution. He eventually had to be intubated for airway protection and underwent temporary pacemaker insertion with overdrive pacing. He had an episode of torsades de pointes with bradycardia and had to be started on isoproterenol drip to maintain tachycardia. This was eventually discontinued as his QTc shortened to 500 msec. He was then extubated several days later. EKG at this time showed normal sinus rhythm, normal PR and GRS with QTc at 450 msec. Echocardiogram showed normal left ventricular ejection fraction and structure. Ventricular tachycardia is serious condition that usually indicates ischemia, cardiomyopathy or a structural disease. Loperamide is an antidiarrheal drug that acts through the opiod receptor, directly inhibiting peristalsis and prolonging intestinal transit time. Dizziness and constipation are the most commonly reported side effects at therapeutic doses however, it is still unclear what is the spectrum of side effects at toxic doses. Normalization of QTc without the need for an antiarrhythmic agent or permanent pacemaker placement only after cessation of loperamide, strongly supports a causal relationship although the exact mechanism still remains unclear.

(C) 2013 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins


http://journals.lww.com/ccmjournal/...entricular_Tachycardia_Storm_Due_to.1130.aspx
 
^^

Exactly. Because for that to have worked, he must have been on a really small dose of a most likely weaker opiate. It really doesn't make much sense otherwise. Most people with even moderate opiate habits have to take somewhere in the range of 100+mg's and often 200+mg's to even start to get relief for their symptoms.
 
Yup. I'm going to have to agree with you there, scag.
I'm just going to guess that he had a kratom or poppy tea addiction. or maybe even tramadol.
lope did absolutely jackshit when I was at my worst in heroin addiction.

Also, he said he felt the effects of lope after ingesting grapefruit juice.. So he really mustn't have had a 'real' addiction, per se.
Hell, I could take a handful of oxy 30's and not feel a damn thing.. maybe a slight headchange... thanks to my heroin addiction.
 
Has someone already uploaded the full paper 'IDENTIFICATION OF AN N-METHYL-4-PHENYLPYRIDINIUM-LIKE METABOLITE OF THE ANTIDIARRHEAL AGENT LOPERAMIDE IN HUMAN LIVER MICROSOMES: UNDERLYING REASON(S) FOR THE LACK OF NEUROTOXICITY DESPITE THE BIOACTIVATION EVENT'?

Having read of overdoses (100s of mg), it appears that BBB transport is rate-limited so the dose-response is biphasic. Once it's overcome the body attempting to remove it, the dose-response curve gets much steeper.
 
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