Opioids Loperamide blocking other opiates?

[teological]

Hello, I have been recently experimenting with Loperamide (Immodium) in doses of about 40mg. I have been usually dosing about one hour before dosing my oxies to help potentiate...
The very first day the lope sort of gave me a body buzz and then when I dosed I felt great..

It has been two weeks now and something has happened. It seems I am not getting euphoria from my oxies anymore. I always get euphoria without fail, and the past couple of days I have been taking the lope then the oxies (around 90mgs) and I DO NOT HET EUPHORIA? This is really depressing me..why am I not getting rushes anymore?

So my two questions

Does lope raise tolerance MASSIVELY to other opiate agonists?

Or

Does lope BLOCK the effect of opiates sort of like a methadone does?

I still can not believe this.

This has been going on for a few days now...

 

[bennyZA]

Why did you take lope to potentiate? It makes your tolerance go up like any other opiate, it just doesn't get you high, at all.

 

[sekio]

Does lope raise tolerance MASSIVELY to other opiate agonists?

yes, this is what's happening. loperamide is actually a pretty strong opioid, it's just removed from the brain very rapidly.

any "potentiation" that results from more oxycodone being in your blood, or oxycodone being there for longer (i.e. from blocked metabolism of oxy, or better absorption, or reduced excretion) is the same thing to your body's receptors as just taking a higher dose...

 

[Mr.Scagnattie]

yes, this is what's happening. loperamide is actually a pretty strong opioid, it's just removed from the brain very rapidly.

any "potentiation" that results from more oxycodone being in your blood, or oxycodone being there for longer (i.e. from blocked metabolism of oxy, or better absorption, or reduced excretion) is the same thing to your body's receptors as just taking a higher dose...

Yeah you would fair better just taking more oxy if you want to increase your high instead of messing with lope. Either way your tolerance is going to go up rapidly if you continue to use at higher doses.

 

[smokemctoke420]

yeah i would'nt fuck with it in high doses. its to dangerous and people have died, including i think 2 BL'ers, 1 being melange and idk the other.

i use it for w/d and i take like 10-15 mgs or so and im good. if you wanna get high just do the oxy.

 

[Lemonopi81]

It could be that just the amt of oxy isnt doin it for u anymore...but the lope isnt gonna help u get up that feelin u had in the beginning....oh the tolerance game...it can just go fuck itself,lol!