No, gabapentin isn't going to help lope penetrate the CNS, by any mechanism I've came across - and honestly, you don't really want lope crossing the BBB, certainly not
in large enough amounts to linger
As far as potentiating, cimetidine snfar superior, and grapefruit juice and cimetidine is the best combo- Tgis will pretty much exponentially increase the amount of loperamide absorbed from GI tract into blood stream; we are talking, as a random(yet realistic) number) 10-15x plasma levels.
Lope is it be be played with. An addict who is desperate can take reasonable doses to help WD; the fact you have gapapentin, well known for treating RLS, and good for opioid wd in general (usually (m) should be enough, with a bit of lope to take the edge off
If your trying to get a buzz from a neurotoxic drug, that the body goes through great measures to keep out of the CNS(even if small amounts enter, they are pushed back by pgp; it would take a moderate-large amount, not to mention without a decent 3A4 inhibitor(s), the BA% is atrocious, less than ~5% average (less than 1% according to some sources, though that would make it undetectable, pretty much) OP, if this is an ill advised experiment, or are you in wd? Answer knowing that the consuqences of casually playing with this stuff are far worse than one would imagine. Note that gabapentin is hit or miss, though would stick with that, if it works for you. An answer would be useful, though in any case, please be careful, and MAKE NO ATTEMPT TO CATCH A BUZZ FROM LOPERAMIDE; it won't work unless you know what you are doing, it isn't worth it, and it's dangerous, and even lethal- H is risky, trying Loperamide just because is absurd (using a procedure to treat opioid wd is a bit different) And again, forget Omeprazole, Cimetidine is superior, though Pure Grapefruit Juice (preferably white) is best- also experimenting with gabapentin has to be done in a certain way, because of BA% issues and also what effects it may or may not have on you
Thats a lot of info, though necessary IMO