RCs Looking for info about a-Methyl-2-Azatryptamine (AMAT)

[sludgekatana]

I have a very small amount of a-Methyl-2-Azatryptamine (freebase), aka AMAT. I can't find any information about this novel compound. Any guesses at toxicity or effects? It's unlikely I'll actually try it until I have some decent info.

 

[pcplease]

you might be waiting a long time for any feedback, lol. those guys have produced so many rc's that ive never read any feedback about. Maybe try the neuroscience forum to see if anyone smart can discern any differences it might have from aMT

 

[Baboooon87]

I have a very small amount of a-Methyl-2-Azatryptamine (freebase), aka AMAT. I can't find any information about this novel compound. Any guesses at toxicity or effects? It's unlikely I'll actually try it until I have some decent info.

Same here. I for sure will not be conducting any research on this before more data is available.

 

[Baboooon87]

I finally did a test run with this compound.

I used an AI tool in which you enter the molecule identifier to generate a table of predictive values for pharmacokinetics and pharmacodynamics. I did not really know how to interpret most of these numbers but what I did was generate the same thing with AMT to compare the two.

The values were pretty similar so I felt confident enough to pulloff a Shulgin and try a small dose. Since the chemical is in freebase form I decided to go down the vaping route so I would know quickly what I was getting into and could titrate the dose more easily.

I started by vaping 19 mgs in a few small puffs spread over ten minutes. I then waited about 15 minutes and did not feel anything noticeable. I then weighted 72 mgs and smoked it in about 7 small puffs waiting a few minutes between each to gage the effects. This was spread over 15-20 minutes before I could definitively tell I was feeling someting and decided to wait and if it would continue building up any more.

The buildup plateaued after a few minutes. I felt a nice rush and my body felt good. Music sounded more immersive and my eyelids dropped like it typically does with empathogen drugs. The effects were very very mild but I am under the impression that vaporising is not an effective route for this. It took a lot of heat so the melting point must to be to high to consume it in this manner. I still have about 150 mgs left so I will probably try to take an oral dose sometime over the next few weeks.

My first impression is that it seems like a milder, less potent version of AMT from the little activity I was able to feel. I also had slight visual activity so it might be a bit more psychedelic than AMT but it is too early to really tell definitively. I am unsure about the total duration. I fell asleep after a few hours because I had not slept the night before so it is hard to tell how long before returning to baseline. I Felt normal upon waking up after a full night sleep. The smoke was a bit harsh on the lungs and I had an annoying sticky cough the next morning. Nothing too bad though.

 

[xdrc]

aMT is active as an entactogen in the 30 mg range oral, vaped much less. If your report is true you are lucky that AMAT seems less potent than aMT. Why did you decide to load 100 mg into a pipe? That seems excessive, especially given your prior experience with aMT. Over which time course did you vape it?

Please for the love of god start with mere μg before, doubling the dose until you hit some kind of activity, then going more slowly from there. What you did seems very reckless to me.

Also it seems like you used SwissTarget Prediction, and it's not at all a suitable tool for what you did (and truth be told, there is none such tool...).

 

[Baboooon87]

aMT is active as an entactogen in the 30 mg range oral, vaped much less. If your report is true you are lucky that AMAT seems less potent than aMT. Why did you decide to load 100 mg into a pipe? That seems excessive, especially given your prior experience with aMT. Over which time course did you vape it?

Please for the love of god start with mere μg before, doubling the dose until you hit some kind of activity, then going more slowly from there. What you did seems very reckless to me.

I started with 20 mgs. I waited about 10-15 minutes and was not feeling much so I loaded 72 mgs and vaped it in many small puffs over another 15 minutes. I did not take it in one blow because my torch lighter was giving up on me and so I could gage the effects gradually. Also, like I mentionned, it did not vape easily so it would have been difficult to vape it all at once. I must admit I suck at vaping and always feel like I waste material when I do it. Someone more used to doing it might be able to take it all at once and get more out of it. That being said, take with a grain of salt what my impression has been concerning potency.

I will be more confident to give an answer on this point after trying it orally as it is the route I use with AMT. I never tried to smoke AMT so a real comparison is immpossible. This is why I said it was only an impression and in my way an actual fact at this point in my experimentation. I have taken oral doses of 100 mgs with AMT ( fumarate salt not freebase ! ) so keep that in mind according to what you are used to with AMT.

You are right that I could have been more conservative with the initial dosage and I do not recommend people to use my approach but this is what I did and I reported on my experience. But μgs ? How am I supposed to measure that amount ? Most mg scales are not even precise enough to mesure anything precisely under 5 mgs.

I just edited the report to give precision on the way I dosed so that people don't get the impression that I vaped 100 mgs in one go. Thank you for making me realise that this is what could be interpreted when reading the report.

The tool I used is ADMET. I never used SwissTarget so I cannot compare both. I agree these tools do not garanty anything for predicting precisely what it will actually do in reality. It only gives a general idea at best by comparing with other more known chemicals that have extensive data on their known effects. This is why a human must try it first to really know what it will do. I doubt we will have any double blind study on this anytime soon so anecdotal reporting is the best we have. Hundreds of reseach chemicals are being discussed on these forums and all of them have been tested the first time by someone somewhere before being used by enough people to gather enough data so that general guidelines concerning it's use and behavioral profile could be given.

I do not recommend anyone to take the plunge and try a new chemical if they are unsure or do not want to assume the consequences if something goes wrong.

 

[xdrc]

μg amounts can be dosed rather safely with volumetric solutions. There is also the technique of serial dilution: https://en.wikipedia.org/wiki/Serial_dilution. Thank you for your elaboration and I'm glad it worked out, but I still stand by this being pretty reckless. I will admit I have done similar things in the past, skipping many titration steps and starting with what could have easily been an active or harmful dose of an unreported drug. As one grows older one becomes more wiser however, and it also helps actually wanting to live.

 

[Baboooon87]

Yes I did think about volumetric dosing but had no propylene glycol or any other smokeable liquid at hand. I almost never vape drugs so I never bothered to buy any.

I will not be vaping this one again for sure because it seems barely active by that route and I strongly suspected it would be the case as soon as applied heat to the pipe. It behaved the same way under heat as other drugs I tried to vape that proved not very active vs other ROA.

I will be much much more careful when taking it orally and consider doing volumetric dosing more in that case as it will most likely be a lot more potent taken that way.

 

[Phobos]

based on my experience with aMT, I recommend waiting 90 minutes in between oral dosages.

 

[Baboooon87]

aMT is active as an entactogen in the 30 mg range oral, vaped much less.

I am not convinced that aMT is that much more potent when vaped. I have never tried it by that route but...

This is why I am under that impression :

1- Potency does not increase at all when plugging it vs oral. I know it means nothing for smoking but you can see that using a faster ROA does not affect potency at all.

2- I do not remember seing much discussion about people vaping aMT if at all in the threads I have read which I find surprising if it is that effective. Drugs with this effect profile end up usually end up being highly abused if they are active when vaporised. The 150 page thread about 3-fpm is a testament to that tendency. Similar effect profile, very active when smoked. Same thing with 5-MeO-Mipt. People love to smoke stimulating drugs with serotonergic empathogenic qualities.

Can anyone who actually tried smoking aMT confirm if this is the case or not ? I might be totally wrong with my reasoning.

 

[xdrc]

I was going by the dosage advice from Erowid. It is possible I'm wrong of course, I do not have personal experience: https://www.erowid.org/chemicals/amt/amt_dose.shtml

 

[Baboooon87]

I was going by the dosage advice from Erowid. It is possible I'm wrong of course, I do not have personal experience: https://www.erowid.org/chemicals/amt/amt_dose.shtml

Ok, interesting, thank you. For some reason I have not been on Erowid for years. I have somehow lost the reflex of cheking things out there since I am doing much less drugs these days. They are not always spot on for dosages but they do mostly have pretty good guidelines.

based on my experience with aMT, I recommend waiting 90 minutes in between oral dosages.

I agree, it takes a pretty long time to build up fully. I would maybe even wait a bit longer than that.

 

[Phobos]

Ok, interesting, thank you. For some reason I have not been on Erowid for years. I have somehow lost the reflex of cheking things out there since I am doing much less drugs these days. They are not always spot on for dosages but they do mostly have pretty good guidelines.


I agree, it takes a pretty long time to build up fully. I would maybe even wait a bit longer than that.

When dosing orally, I would start with 1mg, then 5mg, then 10mg, then a further 10mg.
If still no activity beyond placebo, I would stop and wait a few days then go somewhere around 35mg to 50mg at once if everything seems ok.

 

[HeadphonesandLSD]

When dosing orally, I would start with 1mg, then 5mg, then 10mg, then a further 10mg.
If still no activity beyond placebo, I would stop and wait a few days then go somewhere around 35mg to 50mg at once if everything seems ok.

Good advice.

I also suggest you do not trust an AI tool in the future. It will only parrot whatever data it was trained on (typically, posts on the internet full of misinformation). You don't want to end up like the guy that recently trusted it to ID edible mushrooms and ended up coming destroying angels.

I do appreciate the report for vaping. I've been meaning to get around to aMT for a long time but I've never had the chance to acquire any thus far. More easily obtainable analogs are of great interest to me.

 

[Syntherize]

I finally did a test run with this compound.

I used an AI tool in which you enter the molecule identifier to generate a table of predictive values for pharmacokinetics and pharmacodynamics. I did not really know how to interpret most of these numbers but what I did was generate the same thing with AMT to compare the two.

The values were pretty similar so I felt confident enough to pulloff a Shulgin and try a small dose. Since the chemical is in freebase form I decided to go down the vaping route so I would know quickly what I was getting into and could titrate the dose more easily.

I started by vaping 19 mgs in a few small puffs spread over ten minutes. I then waited about 15 minutes and did not feel anything noticeable. I then weighted 72 mgs and smoked it in about 7 small puffs waiting a few minutes between each to gage the effects. This was spread over 15-20 minutes before I could definitively tell I was feeling someting and decided to wait and if it would continue building up any more.

The buildup plateaued after a few minutes. I felt a nice rush and my body felt good. Music sounded more immersive and my eyelids dropped like it typically does with empathogen drugs. The effects were very very mild but I am under the impression that vaporising is not an effective route for this. It took a lot of heat so the melting point must to be to high to consume it in this manner. I still have about 150 mgs left so I will probably try to take an oral dose sometime over the next few weeks.

My first impression is that it seems like a milder, less potent version of AMT from the little activity I was able to feel. I also had slight visual activity so it might be a bit more psychedelic than AMT but it is too early to really tell definitively. I am unsure about the total duration. I fell asleep after a few hours because I had not slept the night before so it is hard to tell how long before returning to baseline. I Felt normal upon waking up after a full night sleep. The smoke was a bit harsh on the lungs and I had an annoying sticky cough the next morning. Nothing too bad though.

Just because something is in freebase form doesn’t mean that it is vaporizable.

 

[Baboooon87]

Just because something is in freebase form doesn’t mean that it is vaporizable.

I came to that exact conclusion after trying to smoke a few different compounds in that form with very minimal results.

It was the only logical reason I could figure to justify it being sold in that form vs a salt like most other tryptamines are usually sold as.

Would you have an idea what would be the reason for that choice for only a small handful of tryptamines ?

 

[Syntherize]

P

I came to that exact conclusion after trying to smoke a few different compounds in that form with very minimal results.

It was the only logical reason I could figure to justify it being sold in that form vs a salt like most other tryptamines are usually sold as.

Would you have an idea what would be the reason for that choice for only a small handful of tryptamines ?

Which tryptamines? Because N,N-DMT in freebase form can be vaporized at lower temperatures, but you have to have a good technique; otherwise, most other tryptamines are naturally available in salt form.

 

[Baboooon87]

P

Which tryptamines? Because N,N-DMT in freebase form can be vaporized at lower temperatures, but you have to have a good technique; otherwise, most other tryptamines are naturally available in salt form.

In the aMT thread most people seemed to have it in freebase form. I might have seen a few who had it in hcl but most had freebase. No one mentionned that smoking it was a valuable route and it seems to be the case for AMAT from the very slight activity I could feel from smoking a pretty good amount. Not convinced that technique is the problem here it just seems to require way too high a temperature so most of it is destroyed in the process. maybe dissolved in pg or something would protect it or lower the smoke point like it seems to do with nicotine. Anyways, I always prefer having my drugs in salt form. The effects of the freebase versions always feel dulled out, incomplete and unpredictable in potency and activity no matter the route by which I take them. The aMT I experienced with was in fumarate salt and it was amazing. Zero nausea or other side effects even at very high doses. I think the nausea/vomiting and bodyload most people report has much to do with the fact that it is in freebase.

 

[Syntherize]

In the aMT thread most people seemed to have it in freebase form. I might have seen a few who had it in hcl but most had freebase. No one mentionned that smoking it was a valuable route and it seems to be the case for AMAT from the very slight activity I could feel from smoking a pretty good amount. Not convinced that technique is the problem here it just seems to require way too high a temperature so most of it is destroyed in the process. maybe dissolved in pg or something would protect it or lower the smoke point like it seems to do with nicotine. Anyways, I always prefer having my drugs in salt form. The effects of the freebase versions always feel dulled out, incomplete and unpredictable in potency and activity no matter the route by which I take them. The aMT I experienced with was in fumarate salt and it was amazing. Zero nausea or other side effects even at very high doses. I think the nausea/vomiting and bodyload most people report has much to do with the fact that it is in freebase.

I’ve never had AMAT, but freebase cocaine is great in a pinch lmao . It all comes down to the SAR and the MSDS behind the substance in question.