I was given HYcodan and tram to treat pain from pleurisy recently. I had been prescribed it a couple of times in the past few months due to a pesky chest infection that has aggravated the pleurisy, except this last time I was given tram with it. I have perused the forums quite a bit in the past as I am commonly given vicodin for a some bulging discs and had searched for any experiences people may have had taking tram and hydrocodone. Apparently the doc thought it a safe combination or he would not have prescribed them both to treat the same pain. I found it interesting myself, and a pretty pleasant combination, both for pain relief and feel goodishness.