This is a question I have been thinking about recently and is more directed toward the more psychologically minded of this forum but all responses are welcome!
This pertains to the use of such substance's where neuro toxicity is a risk; MDxx, methylone, mephedrone, generally the larger range of drugs where there is a possibility of brain damage or possible serotonin syndrome when serotogenic agonist drugs are combined or even in single use circumstances. Even serotonin syndrome risk aside, generally the wider form of brain damage from using such substances.
In this event is there the possibility where neuro transmitters could be killed to the extent where repeated use of a serotogenic drug used even months later would fail to cause normal positive effect; i.e. the feelings of extreme euphoria, empathy etc as that would have been common place with such a substance prior to any potential neuro toxic damage?
An example is someone having a bad experience on MDxx the third time they tried it, the first time being an experience of positivity and everything a good MDxx experience is. Possible neuro damage may have occurred from taking too much for example or mixing it with other serotonin agonists. Following this third time, even waiting the recommended time between dose so tolerance is not an issue and taking the same doses that yielded such great results prior to the third time they are unable to experience the same intense euphoria and generally positive feelings as before.
I have asked people regarding this and the general response is this can't happen (the people concerned not psychologists in any sense of the word), I on the other hand am not so sure so I thought I would see what the general response on here is regarding such a question.
This pertains to the use of such substance's where neuro toxicity is a risk; MDxx, methylone, mephedrone, generally the larger range of drugs where there is a possibility of brain damage or possible serotonin syndrome when serotogenic agonist drugs are combined or even in single use circumstances. Even serotonin syndrome risk aside, generally the wider form of brain damage from using such substances.
In this event is there the possibility where neuro transmitters could be killed to the extent where repeated use of a serotogenic drug used even months later would fail to cause normal positive effect; i.e. the feelings of extreme euphoria, empathy etc as that would have been common place with such a substance prior to any potential neuro toxic damage?
An example is someone having a bad experience on MDxx the third time they tried it, the first time being an experience of positivity and everything a good MDxx experience is. Possible neuro damage may have occurred from taking too much for example or mixing it with other serotonin agonists. Following this third time, even waiting the recommended time between dose so tolerance is not an issue and taking the same doses that yielded such great results prior to the third time they are unable to experience the same intense euphoria and generally positive feelings as before.
I have asked people regarding this and the general response is this can't happen (the people concerned not psychologists in any sense of the word), I on the other hand am not so sure so I thought I would see what the general response on here is regarding such a question.
