N&PD Moderators: Skorpio
Long acting Nitrous Oxide derivatives?
c0rt3x
Bluelighter
I'm really loving N2O. The more I inhale the more and more intensive get the effects! It feels like a 30 seconds like trip to heaven...
That's why I'm wondering if there was any longer acting derivative of N2O or any other drug that acts in the same way?
chaos_destroy
Bluelighter
have you tried ketamine? its not exactly the same but its similar and works on the same receptors.
cosmic charlie
Bluelight Crew
Try Ketamine or PCP those are both two very potent Dissociative's that I'm sure you would enjoy alot. Also when I'm on LSD and inhale Nitrous it makes the experience seem to last alot longer. Like 10 -15 minutes instead of three. I think you should try some K though , it's a great chemical
CrookieMonster
Bluelighter
when you use N2O while on other substances such as e or any RC it greatly potentiates it and itll seem like it lasts atleast 10x as long and atleast 10x stronger..
Riemann Zeta
Bluelighter
The fact that N2O is a gas makes it an oddball when it comes to pharmacodynamics and kinetics in humans: the absolute bioavailability is less than 1% and the pharmacokinetic profile is 0-order with no in vivo metabolic transformation, meaning that there is no 'accumulation' or dose-dependence to the duration of effects and elimination half-life. The only other extremely small compound (in fact, it is just one atom) with high specificity at the NMDA receptor pore is Xenon, which is (1) expensive as hell and (2) still a gas, so it will be gone is 60 seconds.
It sounds like what you are looking for is ketamine--it fits the description of an "N2O-like experience lasting for around an hour." If you wish to have an even longer, more lucid dissociative NMDA-antagonist experience, you might even consider dextromethorphan.
ebola?
Bluelight Crew
our favorite mathematical function said:
MORE lucid? I find DXM to be so cognitively debilitating as to be useless, at least at high second plateau and above.
...
One anecdote suggests that IV ketamine comes close, but this would be a highly risky thing to do.
Riemann Zeta
Bluelighter
Interesting, even relatively high dose dextromethorphan is far more lucid than ketamine for me. I've never ended a dextromethorphan experience thinking "what the fuck was that, I am so confused."
ebola?
Bluelight Crew
Haha...different brains. Yeah. All I could really think of on my one third plateau (before I stopped enjoying dissociatives) was "I feel robotic", "I'm really fucked up", and "I can't think". Operating a discman was fucking rocket surgery.
IF ONLY it remotely resembled nitrous. The latter is pretty special among dissociatives.
ebola
Cornishman
Bluelighter
I wondered why I got that "reverb" ketamine effect from nitrous.
Thanks for the info. :D
permastoned
Bluelighter
You crazy jesus, you crazy!
DXM Fucks me up personally.. I despise that shit unless it is combined with an opioid, in which instance everything is beautiful. But opioids solve all problems.. temporarily.
Hammilton
Bluelighter
lol women love dating rocket surgeons though!!
I don't think anything that has been suggested thus far can even really be considered nitrous derivatives.
diethyl ether comes close.
Xenon is probably the truest nitrous derivative, but there are the halothane derivatives. They should be cheaper and more accessible, longer lasting too, I think. Xenon is awfully expensive, to the point that it's recycled after it's inhaled for later use. Weird to think that if you're given Xenon in a hospital, odds are those molecules have gone through someone else's blood and brain and body!
Interesting question: Does anyone know if it'd be possible to produce a nitrous oxide prodrug? That might be interesting, though I'd worry about bubbles forming in your blood.
the red shark
Bluelighter
the closest i've come to long lasting nos was penthrax given by my dentist for anxiety i had control over how much i got, it was great!
Hammilton
Bluelighter
Penthrax or Penthrox, I believe the latter is correct, though I'm not 100% on this, is methoxyflurane.
Nitric oxide may be similar, but it couldn't possibly have more different effects! Nitric oxide is reactive, a radical. Nitrous Oxide is a third heavier and relatively inert.
pofacedhoe
Bluelight Crew
poppers are not so nice, and the more frequently they are used the skankier the effects. they are bad for your airways and the blood pressure effects are hardly positive, and with increased frequency probably cummilatively damaging long term.
do you want to look like gordon ramsey? (its his sex drug of choice-eeuw)
melange
Bluelighter
I am pretty sure amyl nitrite is not that bad for you as it is used in medicine for angina and poison gas
isoflurane would be probably the safest of the halogenated anesthetics
ketamine to me truly has a very nitrous feel too it - I take a bump and it feels like I just cracked open a cannister
/navarone/
Bluelighter
Why not tiletamine?
It's analogue of keamine but it lasts waaaaaaaaay longer (3-5 hours) and the effets are less wavy then ketamine but it dissociative and psychedelic/hallucinogenic effects are way better than K.
Unfortunately finding pure tiletamine is tricky, it is normally sold as a Veterinary anesthetic under the name of Telazol wich also contains a benodiazepine derivate called zolazepam which is supposed to potentiate the sedtion.
LabRatNW
Bluelighter
N2O Prodrug... probably not possible.
N2O is chemically finicky. There's no good way to attach it to something else or attach part of it to be oxidized off into N2O. Diazoniums would be as close as I could figure, but they're toxic as hell, not to mention the N-N part would just break off as N2 gas anyway.
