Light LSD effects on the tail end of MDMA experience

[rollonsafely]

Last weekend my girlfriend and I took 350mg of MDMA. About 4 hrs in we decided to take a 1 1/2 tabs of LSD. We both experienced drastically reduced psychedelic effects than the last time we took those same tabs 3 weeks prior. Could this be caused by a depletion of of serotonin, thus leaving less serotonin for the LSD to bind to?

 

[JWills20]

Probably not, LSD is thought to mimic the action of serotonin instead of directly releasing it. Thus, less concentration of serotonin shouldn't really make a difference. If what you were saying was correct, then candy flipping wouldn't work/ would nullify the effects of either drug. Instead they usually synergize, so i'm not exactly sure why you experienced a reduced effect. My best guess would be the classic set & setting.

 

[Sweet Jones]

IME candyflipping can result in completely different synergies between the drugs and is extremely dependent on timing of the dosage, your experience doesn't sound too unusual. I had something similar, when I took MDMA 3-4 hours into an LSD trip, just killed the visuals and most of the trip altogether

 

[Clocktower]

The cause is probably not serotonin depletion per se, but reports of cross-tolerance between LSD and MDMA are quite common. Take them simultaneously for best effects.

 

[Deleted member 290563]

ive heard of lsd's effects being blocked when combined with MDMA. who knows how it works...could be similar to bupe blocking the effects of heroin. ie the serotonin released is blocking the lsd from binding

 

[MrSpeedyG]

I know its a common combo but MDA and MDMA to a lesser extent bind to 5TH2A receptors aswell so possible downregulation could explain why LSD, which exerts its effects through the 5TH2A receptor, effects are diminished.

 

[rollonsafely]

I wad actually in a very comfortable set and setting and never really had any negative thoughts throughout the night, so i think it probably has more to do with the timing of when I dropped the LSD.