Librium / Chlordiazepoxide

[badjessejames]

I was recently put on this drug to help withdrawl from GHB and it was a godsend........the ONLY thing that worked. 20-30mgs every 4 hours.

My Doc has now decided to start a tapering schedule that is moving a little too fast for my likeng, when I told him of this he answered that it might not be all that comfortable.

I remember reading somewhere on BL that grapefruite juice when taken with certain meds greatly helps the absorbtion rate of the drug......reading the Librium literature it seems one of the things you are NOT supposed to take with it is GF juice.

Question is....I tried searching for that post and came up empty...any suggestions on giving the Libs a little more kick than they are supposed to have?

Thanks All................................jj

 

[Morrison's Lament]

Sorry, the whole citric acid thing is a very persistant urban myth.

About the only thing that I can think of that would give Librium a decent extra kick would be a little bit of alcohol, but be very very careful when mixing these.

--- G.

 

[badjessejames]

It wasn't citric acid .....it was something found only in grapefruit juice that temp impaired an enzyme in your intestine that eats half of certain drugs such as opiates......I don't know forsure what was ssaid about benzos but after reading grapefruit juice on the contraindictions....it made sense.

Does noone else remember this post......it was long with plenty of references.... Oh well....maybe I'll try it anyway

 

[badjessejames]

FOUND IT!

Taken from an old phreeX post with much respect:

This is a really good site... it's called "The grapefruit juice effect" ... there is also a list of medication here - YES, you had BETTER DRINK SOME GRAPEFRUIT JUICE WITH THOSE BENZOS ... the website: http://pharmacology.about.com/healt...y/aa000522a.htm
Here is part of the article -
The mechanism of the grapefruit juice effect is probably that one or more of the chemicals (most likely bioflavonoids and/or furanocoumarins) in grapefruit juice decreases the amount of (or inhibit the activity of) one or more specific enzymes in the intestinal wall and liver. These enzymes include CYP1A2, CYP3A3, and CYP3A4, which are part of the cytochrome P450 (CYP) family of enzymes. The CYP3A family of enzymes is thought to metabolize or inactivate approximately 60% of all drugs. These enzymes normally decrease the amount, via metabolism, of certain drugs which enter the systemic circulation. Thus when the enzyme is inactivated or the amount decreased, the amount of the drug entering the bloodstream is increased. This can result in increased therapeutic activity and possibly toxicity of the drug. Cytochrome p450 3A4 (CYP3A4) is currently thought to be the major enzyme affecting drug metabolism which is inhibited by grapefruit or grapefruit juice. Hence, any drug normally metabolized by that enzyme may show increased effectiveness and/or toxicity when taken with grapefruit juice. Such drugs are listed in The Grapefruit Juice Effect: Part 2 - Medications List.
Although the emphasis has been on possibly dangerous interactions of drugs and grapefruit, the interaction can also be beneficial. According to the Boston Globe, a kidney transplant patient began taking grapefruit juice along with the immunosuppressant cyclosporin, and cut the cost of his medication from $12,000 a year to $6,000. Some drug manufacturers are now trying to incorporate the active ingredients of grapefruit juice into various pills to increase their availability after oral administration. In fact, one company, AvMax, Inc., was recently issued a patent for this technology. That company hopes to develop oral dosage forms for some anticancer drugs, such as Taxol and Taxotere, which can currently be administered only IV.





I'm going to the grocery store........PeAz.............JJ

 

[badjessejames]

Some more incase anyone is interested

ALOT OF GRAPEFRUITE JUICE INFO

I hate the shit ......but for half the drugs....

 

[Hypnotize]

The obvious answer would be to combine them with some opiates, but this is a harm reduction site, so yea drink some grapefruit juice or something. Let me know if it works...



blahblahblah...

 

[Morrison's Lament]

I stand corrected, sorry!

The citric acid myth thing actually came FROM this actual factual research. People started saying you could use OJ instead and that it worked with E and all other drugs.

So, once again, sorry, I hate to misinform.

--- G.