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Lefetamine???

Canis aureus

Canis aureus

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Nov 25, 2005
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Hey, does anyone know what is lefetamine's mu-agonist activity like? (I mean, is it comparable to fentanyl's selectivity, or is it perhaps both mu and delta receptor agonist?) To what opiate/opioids it is comparable? Is it whole agonist, not partial or mixed, anyway?

And how does its opioid activity changes when its stimulant activity changes? How do its analogs bind to certain receptors?

Very interesting molecule!
 

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Well, based on it's molecular structure it's not surprising that it has stimulant effects... it resembles phenethylamine stimulants like amphetamine.

It is a bit odd shaped to me a u-agonist, but nevertheles shows pretty strong affinity to that receptor (about equal to morphine, I've read in most articles on it).

I'm not sure exactly what you're asking.

It would be one hell of a drug of abuse though. A speedball in one drug, imagine using this IV.
 
Ah, yes. Just in time for the annual Lefetamine thread to pop up!

This is one drug that everyone seems to want, yet no one wants to make, even though it is no more difficult to synth than MDA.

And FYI, it is an NMDA antagonist as well, making it like a speedball + K.

Apparently it was briefly abused in Italy and Japan many decades ago and was banned, never to be seen again.

I opened a thread on it on this forum a few years back. Do a search.
 
otb01 said:
Hm. This has never hit the RC market?
Click to expand...

Nah its listed on the UN drug schedules so its illegal everywhere in the world.

The RC suppliers tend to go for ones that are at least borderline legal in most countries, and illicit drug manufacturers usually just go for things like meth or MDMA that there will definitely be a market for.

Surprising lefetamine hasn't shown up at least occasionally though given the fairly simple structure, it must be pretty straightforward to make.
 
i am not asking how, and i do not want further instructions. Let me ask this one question though.

From what do you make it?

I hope that is not a synth question. We all know that we can make meth out of ephedrine, so i think this question is okay.
 
^ As long as it's just the starting material and not part of some detailed synthesis scheme


Actually, fencamfamine (yes I'm on about it again!) has mu agonist activity and it has a phenethylamine backbone in it, just as the potent opiate/mu agonist tilidate has as well. I'd guess the NMDA activity comes from the amine group being on a benzylic carbon atom (as it is in PCP, ketamine etc), just it's not part of a cyclohexyl ring
 
yay :) would it be the same precursor as for meth?

It has a somewhat morphinan-like structure, that's for sure. If you'd connect the 2 rings you' end up with 3, and if you could bring the amine to form a bridge, add some methyl and ethyl groups it would look a helluva lot more like something opiate-esque. So i can see why it would have opiate activity. This compound looks really interesting. Are there any experiences or reports on it?


// ahhhh i wish chemistry would be as easy as putting together Lego or Fisher Price =D
 
Fritzy recently included a massive article collection on asymmetric reductive amination. I think the fact that most of the activity resides in a single enantiomer has got to at least partially account for why nobody has bothered introducing this molecule on to the black market.

I also would like to know about dosage. Is this something that is active at 10mg or 100mg?

I think it's made out of benzylphenylketone, which requires dealing with a chemical company.

(assuming one doesnt want to make the precursor themselves)

I think it's only a matter of time before it eventually rears its ugly head back onto the black market.
 
Think it was supplied in 50mg pills? Heres a case report of someone shooting 60mg 20x a day so it can't be that potent...

A case of lefetamine abuse (0.9-1.8 g/day in 15-30 i.m. divided doses) is reported. In this patient, the administration of naloxone precipitated a mild opiate-like withdrawal syndrome, characterized by mydriasis, piloerection, yawning and a slight increase of blood pressure. The complete withdrawal of lefetamine, substituted by a placebo regimen, aggravated these symptoms.
Click to expand...
Pharmacol Res Commun. 1984 Sep;16(9):915-22.
 
15-30 IM doses a day? You'd look like a fuckin pin cushion (and run out of admin sites fairly quickly) I mean 210 injections in 1 week into the areas diabetics use for IM eould end up with what looked like an allergic rash all over those areas (when I've had a ket weekend binge and administered it say 10x a day for 2 days, by the end of that I'm sore all over the IM sites), as you know they're not going to use 210 clean needles - some will get reused & that'll hurt
 
It cant be THAT potent, but it still should be 50-100mg dosage which puts it on a parr with something like tramadol (minus the fact that there is no incidence of 5-HT syndrome, plus this is probably nastier aka more "industrial").

For instance, ive seen stories about users of angel dust who escalate up to the point where they can take several hundred mg per day, which is basically relying on people having a monster tolerance and is not just the standard dosage. But, it does still seem indicated that the enantiopure product is gonna be required (levorotatory isomer).

You see with compounds like levomethorphan, it is acceptable to have an equal amount of dextromethorphan. Therefore racemorphan is all that is needed. Here, though that does not seem like it would be sufficiently active enough not to mind about it.
 
As for the synth, without going through any details:

If Asarone makes TMA-2
And Saffrole makes MDMA
And Anethol makes PMA
And (etc..) via the same synth,
Then Benzoin makes Lefetamine

(or so I've heard).
 
fastandbulbous said:
15-30 IM doses a day? You'd look like a fuckin pin cushion (and run out of admin sites fairly quickly)
Click to expand...

haha nice analogy =D

Hey Jamshyd,
that gave me a good idea of how the compound is derived. How would this route be different from synthesizing a morphinan compound? Something similar, or would it be a complete different way? I hope that question is okay.
I'm just trying to understand how these different compounds relate to each other, and if they had a similar synthesis route it would be even more likely that activity is somehow related?
God, i don't know...
 
Jamshyd said:
As for the synth, without going through any details:

If Asarone makes TMA-2
And Saffrole makes MDMA
And Anethol makes PMA
And (etc..) via the same synth,
Then Benzoin makes Lefetamine

(or so I've heard).
Click to expand...

well now that sassafras oil is illegal i wouldnt go as far to say mda is easy to synth unless you know what you are doing with *edited* or *edited*. and if youre going to go from *edited* to mda you might as well make (easily) *edited* and go down the mdma route. and let me know if this is to many details mods...

edit: and wow i never really looked at anethol. the synth to PMA would be rather easy if one were inclined to do that.

cleaned up post for synth reasons...
 
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The availability of sassafras is irrelevant to our discussion. Since I listed all other substances, assume as if you were starting from pure saffrole. Then read PiHKAL and look at my post again.

My post was not supposed to be a synth recipe.

It was a little (idealised) riddle that any chemist who knows his Essential Oils should easily figure out. I am not a chemist myself, and in fact do not understand either reply to my post (ask anyone! haha).
 
i have yet to read through PiHKAL or TiHKAL although they are sitting on my bookshelf. i kinda wanted to read up and learn orgo before dipping into his books because at times it seemed overwhelming in the back parts if you know what i mean. and my post was kinda a half-assed response to the one you posted earlier in the thread. if starting from pure safrole it all makes more sense now 8-)
 
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