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Lefetamine???

CAS: 10016-75-8
CAS: 451-40-1
Name: 1,2-Diphenyl-ethanone
Name: Benzyl phenyl ketone
Name: Deoxybenzoin

This, dimethylamine and a borohydride will yield raecemic product. Then it's down to partial crystalisation to produce an optically pure product. I don't think it's production that is the problem but rather bang per buck...
 
I dont think that there's anything wrong with lefetamine per se but as haribo1 points out, potency is not in the region where a microspatula is gonna have much (if any) meaningful effects.

There was an article mentioned at one time where a host of SAR studies were done and a number of more potent analogs were elucidated.

It's just odd that people seem more inclined to talk about chemistry than actually get their hands dirtied in the lab attempting to make the said compounds.

What it boils down to is actually people being afraid of conducing an asymmetric synthesis. If peoples inhibition to that mental hurdle can be overcome then the black market will become flooded with lefetamine.

The total synthesis is also not well documented. Sticking a p-methoxy/chloro on one of the phenyl rings for example might make for an interesting compound.

Maybe it's time that somebody like Meltzer decided to run an extensive SAR study like what he did recently for the pyrovalerone series of compounds. I think that it's merited.
 
perhaps those who have the ability have no interest in the scratchy constipated brain dulling world of opiates and opioids. add to that the global legal status of lefetamine and it seems unlikely to appear.

there may be a black market for lefetamine as an intrinsic speedball but I hope it never appears.
 
is this coincidence, or does anybody from you guys here live on vancouver island? I *just* heard 2 of my buddies talking about it, and how it's utter crap apparently. Do i maybe secretly know one of you guys? When i asked them they told me to mind my own buisness...

Vancouver island anyone 8o ?
 
perhaps those who have the ability have no interest in the scratchy constipated brain dulling world of opiates and opioids. add to that the global legal status of lefetamine and it seems unlikely to appear.
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Maybe in a perfect world. I hope you don't really believe that !! ;)
 
Ham-milton said:
Maybe in a perfect world. I hope you don't really believe that !! ;)
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like many others I have no interest in them whatsoever and I know I am not alone in thinking that the world already has enough opioids...
 
No, I simply meant that it seems naive to think that no one with the capability wouldn't be interested in making it. Whether for themselves or profit.
 
true, ^ MDPV has been made and so has desoxypipradrol
and further one would expect to have seen it widespread before now if it was any good.
A quick look at the literature showed a couple of occurrences in Sweden and italy in the last couple of decades, then the last major use was Japan in the 1950's.
 
but both of those are analogues, and not specifically scheduled. With so many clandestine chemists busy making analogues, I don't think we'll see many obscure-ish scheduled drugs.

Soon there'll be a move for a UN Convention on Analogues, I'm sure, and that'll put an end to the party.

If lefetamine is a pretty easy synth, from readily available start material, that'll probably be when we see it on the street.

Unless there's an analogue that retains it's opiodergic/dopaminergic nature, I doubt we'll see it before analogues are no longer quasi legal.
 
What it boils down to is actually people being afraid of conducing an asymmetric synthesis. If peoples inhibition to that mental hurdle can be overcome then the black market will become flooded with lefetamine.
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Who in their right mind is gong to post here sating,"guess what I knocked up in my garden shed lab yesterdat, are they? I know analoges have been synthed & tasted, but nobody's going to announce to the world their potentially very illegal, very recent activity
 
Like i said before, Fritzy recently did a big literature search including articles from both academic and patented literature on asymmetric reductive amination.

When I first saw lefetamine my initial reaction was that a compound requiring a single isomer was something that had to be shelved in preference of compounds where the racemic product possees an acceptable level of activity.

I also think the difficulty people have with setting up accounts with big name chemical companies must be at least partially to blame. Where does one go and buy the precursors needed to make this?

The people in europe making all the illicit drugs are probably poorly educated. They prefer to make bricks of amphetamine, go and buy MDP2P by the drum, get involved in the trafficking of cocaine and heroin, or cannabis. Then theres also the diversion of pharmaceticals on to the black market.

Real life chemists are MUCH rarer. They account for much less than 1% of the total market. Then the RC market which is already quite small relies on quasi-legal compounds and Asian chemists who wont touch illegalized compounds.

Ocassionally self-taught chemists account for some of the market but they are driven by greed rather than a desire to provide the market with drugs for spiritual enlightenment or self-enrichment.

The total share of the market containing genuine chemists is probably like 0.1% who account for ALL of the LSD for instance.

That's the reason why lefetamine is so rare is that there is a shortage of "real" chemists.
 
Asymmetric reductive amination with 1,2-diphenylethanone, (S)-a-methylbenzylamine, Ti(O-i-Pr)4, amd Raney Ni in hexane, H2 @ 60-120psi should yield the desired stereoisomer as majority product in diastereomer mix, which will will then need to be purified with chromatography or crystallisation, followed by hydrogenolysis w/ Pd/C @ 60psi H2 (one could use PTC instead here, I think), and then reductive amination with NaBH4 & HCOOH in GAA to dimethylate the N, to yield pure active enantiomer of Lefetamine :) .
There are probably better ways of doing it but that's just my first impression from reading one paper on asymmetric reductive amination.
 
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Fritzy collects papers like nobodys business. I once had to carry them and it almost did my back in (this was over 12 loads).
 
Also, why do we have to produce only one stereoisomer? Is the other one toxic or something? Lefetamine is a piece of cake to synthesize if one is unconcerned about chirality, and besides, if you felt strongly enough about it, you could probably resolve the enantiomers with a tartrate.
 
The MAJORITY of amphetamine in the UK was not actually made here but comes from countries like Poland. Almost all of the XTC is made from commercially available MDP2P which is costs a few grand for several GALLONS. The % that is made from sassafras oil probably accounts for less than 1% of the total market share.

^One does not need formal education to make the above drugs. A few courses at college is all that is needed but forget about university. Most of my university colleagues now have well paid jobs in the industry. The last thing they would wish upon themselves is to jeopardize the fruits of their labor by doing something that could see them serving a lenthy prison sentance.
 
hope i can ask that: What is MDP2P used for other than the synthesis of illegal things anyway?

I think the sassafras route is being used by the small-one-time chemists that probably just want something for themself, and that don't have illegal connects or whatever. That's what i think anyway.
 
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^ well hope you know that sassafras essential oil is technically illegal now, so i would think you would need an illegal connect to get that (in the us at least). there is always eugenol and catechol, but from my knowledge that methoxy bond on eugenol is a little bugger and there really isnt a fool proof method to demethylate it without hard to get chemicals/toxic chemicals. Myristicin would be nice, but by the time you would get rid of the whole methoxy group the methylenedioxy ring would be broken, i think. (-)OCH3 isn't the best leaving group with no resonance to stabilize the charge or any electron withdrawing groups, (*edited* - sorry if too much info) correct me if im way off. anyways, not sure what else MDP2P or phenylacetones for that matter are used for outside of being precursors... ok sorry for rambling. im done...
 
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What? Since when is sassafras essential oil illegal? I saw some at the botanical shop yesterday morning?!?! Is it only by the drum or small scale too???

Most of the worlds illicit drugs are made by morons. Coke, heroin, amphetamine, meth, just a bunch of cokes or less- someone who can handle an extraction and purification.

Is there any effort with cocaine production to convert the ecogine? I don't think so, but I dunno either (I have no idea about how it's done, it's not what all the KMnO4 is used for??)
 
Ham-milton said:
What? Since when is sassafras essential oil illegal? I saw some at the botanical shop yesterday morning?!?! Is it only by the drum or small scale too???

Most of the worlds illicit drugs are made by morons. Coke, heroin, amphetamine, meth, just a bunch of cokes or less- someone who can handle an extraction and purification.

Is there any effort with cocaine production to convert the ecogine? I don't think so, but I dunno either (I have no idea about how it's done, it's not what all the KMnO4 is used for??)
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ok, not necessarily illegal, but a HIGHLY watched chemical by the DEA and you need a license to buy in quantity. and there are sassafras oil impersonators that are actually safrole free or contain VERY little amounts.
 
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