60units
Greenlighter
This post is intended to prevent accidental overdose.
Here on Bluelight I imagine most people have had (a) friend(s) or family member(s) pass as a result of intentional or accidental drug overdose. I would be willing to guess that because LD50's tend to be pretty high when they're measures in rats, the overdose occurred below or even nowhere near the LD50.
Is it the fact that combining drugs and alcohol give a synergistic effect?
Is the applicatiom of lab rat LD50's wildly inaccurate?
Can anybody suggest anything else?
For the sake of discussion, the oral LD50 of oxycodone is 482. That's 482 mg for your weight in KG. A 75 kg man would have to take 36,000+ to have. 50% chance of dying. That's just not how these overdoses occur accidentally or even intentionally. Even intravenously where the LD50 is 20, one would have to inject 1,500 mg.
What are the other factors that influence these overdoses? I'm primarily concerned with the big culprits: opiates and benzos.
Here on Bluelight I imagine most people have had (a) friend(s) or family member(s) pass as a result of intentional or accidental drug overdose. I would be willing to guess that because LD50's tend to be pretty high when they're measures in rats, the overdose occurred below or even nowhere near the LD50.
Is it the fact that combining drugs and alcohol give a synergistic effect?
Is the applicatiom of lab rat LD50's wildly inaccurate?
Can anybody suggest anything else?
For the sake of discussion, the oral LD50 of oxycodone is 482. That's 482 mg for your weight in KG. A 75 kg man would have to take 36,000+ to have. 50% chance of dying. That's just not how these overdoses occur accidentally or even intentionally. Even intravenously where the LD50 is 20, one would have to inject 1,500 mg.
What are the other factors that influence these overdoses? I'm primarily concerned with the big culprits: opiates and benzos.
