Opioids kratom extracts

[Hammilton]

I think the oxindole enhanced stuff contains some synthetic mitragynine analogue with significant affinity for delta opioid receptors. That would explain the stimulation it produces

 

[Doldrugs]

Do you guys find extracts lower blood pressure? I've generally found them to feel speedier but I overdid it last night and when I smoked some hash to try and alleviate some of my suffering I had all the symptoms of a sudden drop in BP, which is not something I've experienced on either drug alone in a long time. It was an enhanced Bali, so it was definitely more sedating than the UEIs I've tried.

 

[Stotched]

Do you guys find extracts lower blood pressure? I've generally found them to feel speedier but I overdid it last night and when I smoked some hash to try and alleviate some of my suffering I had all the symptoms of a sudden drop in BP, which is not something I've experienced on either drug alone in a long time. It was an enhanced Bali, so it was definitely more sedating than the UEIs I've tried.

I've found smoking hash with any form of kratom, even plain leaf, tends to lower blood pressure and make everything extremely sedating. There have been times I've felt severe resperatory depression off 8g of plain leaf bali, and one dab. It's odd because kratom in itself is not supposed to cause resperatory depression. However, cannabis is also an agonist at the delta, and kappa opioid receptors, and also modulates how the MU receptor works as well.

Not many people realize that cannabis highly affects opioid receptors, so I feel that this has something to do with the sedation when added on top of kratom.

 

[Doldrugs]

It wasn't just sedation, I also experienced panic, temporarily lost my hearing, felt dissociated, blurred vision, clammy skin, etc. I laid down and felt better. Luckily I've become comfortable dealing with panic the last few years and I recognized the symptoms of hypotension so it didn't cause me much mental grief. It was quite uncomfortable physically, however.

 

[《Plasticity》]

I've had lowered blood pressure from kratom but nothing extreme or worth panicking over, however I only used enhanced plain leaf a handful of times. Were all your symptoms acute? I've experienced all your symptoms from kratom use before to some degree, perhaps besides the dissociation, so I'm wondering if this was panic related... just a guess.

Weirdest were the hearing issues, likely unrelated to BP in my case though. Kratom used to cause temporary bouts of tinnitus, like when hearing dims out followed by ringing and a slow return to normal hearing... not sure why. I wonder if kratom is detrimental to hearing like other opioids. I've personally never felt any dramatic increase in respiratory depression with the addition of cannabis, which I smoked/ate alongside all my doses... maybe to some extent with stronger extracts but like I said, nothing near dramatic.

I think the oxindole enhanced stuff contains some synthetic mitragynine analogue with significant affinity for delta opioid receptors. That would explain the stimulation it produces

How would you say the oxindole extracts compare to UEI/FST Ham? Worthwhile?

 

[Doldrugs]

The lightheaded feeling, blurry vision, clammy skin, and shallower breathing were from the BP drop. I'm assuming those symptoms triggered the panic, which led to the loss of hearing and dissociation, and also worsened the lightheadedness and breathing. It feels weird to call it panic, because I was relatively calm emotionally. I don't take anything to treat the physical symptoms of panic attacks because I like to minimize the medication I'm on and these episodes are infrequent and short lived.

 

[《Plasticity》]

Hmm, strange that your blood pressure would drop that low. Both Mitrphylline and Rhynchophylline are anti-hypertensives, Corynoxeine is a calcium channel blocker, Ajmalicine and Tetrahydroalstonine are anti-adrenergic (the former working on a1 subtype while the latter on a2) so that's a nice little selection of alkaloids for BP but given that a few of these are present in miniscule amounts and there are also adrenergics to counteract some of these effects there shouldn't be significant drops in BP.

Maybe your vendor only enhances with mitragynine and 7-OH Mitragynine and adding those to an already low adrenergic strain caused too much sedation to counteract some of these alkaloids causing what you experienced. If this isn't a regular occurence then alas, I've got nothing else...besides avoiding the culprit of course, in this case enhanced bali *shrugs*.

 

[Doldrugs]

I took WAY too much... 7 grams enhanced. I have no excuse, it was stupid. 3 is a better dose for this shit, I had a great time adding 3 grams to 5 grams plain leaf. Normally I need like 15 grams plain to catch a buzz at all so getting pleasantly high on 8 grams should have clued me in. I don't normally make shitty decisions like that. At a reasonable dose I doubt there will be issues, and if there are I can abstain from the hash. I was just surprised I had such a strong negative reaction to the weed, I haven't experienced that in like 10 years.

Oh I forgot to mention I was shaking like a leaf, but that could have been the panic. I think it was the BP, though.

Maybe your vendor only enhances with mitragynine and 7-OH Mitragynine

Likely. It's a pleasant product alone but feels much fuller and smoother mixed with plain leaf.

 

[《Plasticity》]

Was this your first time mixing cannabis with kratom? Also, did you have something in your stomach before ingesting kratom? Eating kratom on an empty stomach sometimes makes me feel a similiar type of weak with faint feelings, sweaty but clammy skin, and bp issues and that added to an even more decreased blood sugar from the cannabis can cause or worsen some issues you experienced. These are just guesses of course, kratom could've very well just caused a downward spike in your bp. Though I honestly suspect that there were more factors like some of the stuff I mentioned as people don't typically experience such significant drops in vitals from kratom consumption.

Either way if this continues with the enhanced bali then I would cut that out and switch back to plain leaf, this isn't exactly the most common of occurences and it's a bit suspicious coming from an enhanced strain. Not that I'm suspecting any adulterants at play however, maybe the tampered alkaloid profile is could be to blame. Just be careful next time. Btw, shaking/tremors is extremely common with dosing too high... be sure to keep within your limits.

 

[HdoubleODeezy]

Bringing back the topic of extracts (minus the UEI being mentioned).. the best extract IMO is one you make yourself with the plain leaf you usually use.
You know exactly how much is in it and how much came out of the batch so you know the almost definite strength of the extract you've made.
Of course you could just buy it, much easier and saves the whole "process" you need to do to make the resin (which you could then grind into powder) but i have made (pretty decent) 8-10x resin a few times before. A vendor could make the same and label it as 20x and make some money.

I usually just take regular PC/bali powder and it works fine for me at 10g so really no need to make an extract, but i wanted to try it after i saw a guide on how to do so and watched a video on youtube. Turned out 1g of the extract felt like 10g powder and i used 250g powder to make it and came out with almost 25g after the process was said and done. Was kind of proud of myself lol.

Just my opinion, of course i would like to try UEI which i have not had the pleasure of doing so yet.
Back to my point.. if you want an extract you know the strength of and can trust.. make it yourself, rather easy IMO/IME.

-HOOD

Edit: Sorry to go off track with what you guys were talking about.. my bad. I'll stay out of the convo, i just wanted to say that.
That is all, thank you. lol. (Mind's racing)

 

[《Plasticity》]

No need for apology, this thread is as much ours as it is yours...

 

[Doldrugs]

Yes, it was my first time mixing them, I was well beyond my limit, and it was very potent hash made from a strong sativa. I took it on an empty stomach with orange juice, but the symptoms persisted even after I ate.

 

[al-laddin]

I've had lowered blood pressure from kratom but nothing extreme or worth panicking over, however I only used enhanced plain leaf a handful of times. Were all your symptoms acute? I've experienced all your symptoms from kratom use before to some degree, perhaps besides the dissociation, so I'm wondering if this was panic related... just a guess.

Weirdest were the hearing issues, likely unrelated to BP in my case though. Kratom used to cause temporary bouts of tinnitus, like when hearing dims out followed by ringing and a slow return to normal hearing... not sure why. I wonder if kratom is detrimental to hearing like other opioids. I've personally never felt any dramatic increase in respiratory depression with the addition of cannabis, which I smoked/ate alongside all my doses... maybe to some extent with stronger extracts but like I said, nothing near dramatic.


How would you say the oxindole extracts compare to UEI/FST Ham? Worthwhile?

What I had no idea that opiods effect hearing long term??? Wow news to me....Yeah I never thought ot was related to kratom but I feel one ear well muffle out and a ringing will set in and then fade back out...always one ear...the event lasts maybe 5-10 seconds. Probably happens 1-3 times a day. Never thought it was kratom related

 

[《Plasticity》]

Yeah definately, I think it's far from strictly anecdote that some opioids are straight up bad for your hearing. IIRC, codeine and it's derivatives are the worst at causing this effect. You can find a bunch of studies and forum posts with a google search if your interested. Although kratom caused these bouts of tinnitus I wouldn't say my hearing has been affected at all, It also wasn't common for me to have this issue when using traditional opioids so I'm not even sure if they're related to hearing issues. I'd like to believe kratom isn't ottotoxic, but it's up in the air I guess.

 

[pinpoint]

The only time I developed tinnitus was when I was dosing kratom heavily. I don't know if tinnitus is a sign of ototoxicity, but you should also remember that kratom is produced in a 3rd world country. In 3rd world countries they are still using some nasty insecticides like DDT, which has been linked to cancers of practically every organ in the human body among with a host of other harmful effects and has been banned by every modernized country. Call me paranoid but this was a big part of the reason I am on a semi-permanent kratom vacation. Consuming an ounce of powdered leaf per day is over 28,000mg of an unregulated substance from a 3rd world country.. no thanks.

Nevertheless, DDT and several other organochlorine insecticides are still being used for agriculture and public health programs in developing countries in Asia and the South Pacific.

http://www.ncbi.nlm.nih.gov/pubmed/9297984

 

[《Plasticity》]

While DDT is no good, I highly doubt the tinnitus issues are related. I couldn't find anything correlating tinnitus with DDT poisoning through a google search. I do however agree that it's important to remember where this stuff is coming from, I had a similar concern about H.pylori infected kratom a while back. H.pylori bacteria runs rampant in third world countries and all it takes is a cough or a sneeze to spread it. You think those poor migrant workers aren't coughing or sneezing into their hands and continuing work? It's notlike they whip out some hand sanitizer or where masks when handling kratom.

 

[pinpoint]

Yeah I kind of just used the tinnitus as a segway into a completely unrelated subject

Also, I did sample an oxindole extract (but as you know CK I haven't tried the UEI so can't compare) and found it to be similar to oxycodone - very speedy and euphoric but with a kratom touch that sort of limited the dosage curve to a more tame level.

 

[《Plasticity》]

Thanks, I've actually never tried an oxindole extract because it was usually described as very speed and not as clean as UEI...maybe I'll give it a try one day, but for now I'm enjoying my weekly serving of UEI so it can wait . Sounds better than a full-spectrum extract though... how long did the buzz last?

 

[al-laddin]

Dude Ive thought about the insecticide issue....but usnt a lot of it harvested from the wild? Wishful thinking I suppose... but Id bet that even if it was farmed , that either they don't use insecticides or if they do they would notice problems from consumption of these poisons and hopefully cease the use of more toxic crap. Plus CaptainKratom, that vendor I emailed you about is fucking amazing ...I don't know if you checked the link but Ive never seen lower prices and some of his strains are local US....maybe Ill stick to those

 

[pinpoint]

Dude Ive thought about the insecticide issue....but usnt a lot of it harvested from the wild?

Hah someone's been drinking the Kratom kool-aid.. so what, every time you place an order for super bomb bali a grey-haired Buddhist monk ventures out to the great forest with his trusty walking stick to harvest your kratom? Playa, please. Kratom is an industry like any other with large agricultural plantations. It has been said by several vendors that in fact an American living in Thailand has managed to corner roughly 90% of the export trade of Kratom coming out of SE Asia. That would ensure the capitalistic mindset of profit > * would prevail in that market like it does in any other.

CK, acute effects 2-3h, but seemed to linger for quite some time thereafter.