I have tried it a few times recently, actually. I've combined kratom and phenibut many times in the past. I decided to try picamilon and kratom as a replacement to the kratom phenibut combo. While it is a decent combination, it isn't as strong as the phenibut/kratom combination. I've never abused phenibut but I know that it comes with bad a withdrawal if one does abuse it. I decided to replace the phenibut with picamilon as a "safer" alternative to phenibut. I must say that I have a high tolerance to kratom. I'm relatively new to picamilon but my dosages when combined with kratom have been anywhere between 250mg to 500mg. I typically take the picamilon a few hours before the kratom. It's a very relaxing combination but I wouldn't say that the picamilon potentiates the kratom rather it compliments it with a relaxing feeling. If you've never tried phenibut and kratom then I must recommended that as well. Phenibut usually is slow but long acting. It usually takes 2hrs before you feel effects with the peak occuring around 5hrs after taking it. Knowing this, I typically took the phenibut 5hrs-8hrs before the kratom. Then in the evening I would take the kratom and exprience bliss and extremely restless sleep that night. I must warn you about phenibut, though. It is strong and can be addicting. If you are new to it then experiment with phenibut alone before combining it with kratom. That way you can find the right dosage of phenibut. I typically took 2.5gram-3grams. Don't use phenibut daily. I wouldn't even recommend using it more than 3 consecutive days.