Okay, so I was thinking about this the other day, but it's hard to put into words. So you know when you take a drug (smoke a joint, pop a pill,ect.) and you take more of that drug within like 30 minutes of the first dose it magnifies it. It makes you feel "higher". But if you were to take a dose and than take another like 10 hours later or so it might slightly boost your high but you can't feel it as much. This we can assume is tolerance. So when does a drug stop increasing in effects and tolerance kicks in? Is it that our brains cannot brace itself for the drug when its first taking affect? Does the drug have to be in the half life stage for your brain to be prepared for the next dose? I hope you guys know what I'm asking lol. I was just curious why you can take a drug than take more immediately and its effects increase but if you wait to long for the next dose you only feel it a little.
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BDD Moderators: Keif’ Richards
kind of a question about tolerance
- Thread starter olab7
- Start date
I think the answer to your question can be simplified into the fact that taking two doses in a close proximity causes a stronger overlap and an additive effect. If you leave a period of time between dose A and dose B the chances of an overlap are minimized as the longer you wait, the more time dose A has to wear off. If dose A becomes weaker, then naturally dose A + dose B will become weaker.
Venrak
Bluelight Crew
^This.
Not to get too much into it, but conditional tolerance probably has something to do with it, like the OP wondered when mentioning the brain's ability to "brace" against the effects.
General Info on Conditioned Drug Tolerance
Not to get too much into it, but conditional tolerance probably has something to do with it, like the OP wondered when mentioning the brain's ability to "brace" against the effects.
General Info on Conditioned Drug Tolerance
Yes, what the other two said - to a point.
Doses administered close enough together provide a synergistic response to the applied stress. That is the initial dose (stressor) is essentially increased as the first neurophysiological response is still reacting when the second dose (stressor) is administered compounding the first response.
Tolerance is adaptation. A gift in most instances, but a curse to recreational drug users. We (humans) physiologically adapt to applied (increased) stress. Medication applies an exogenous (and endogenous through chemical reaction) stress eliciting a neurophysiological response (pain relief, sedation, euphoria, etc). The biological organism (us) is programmed to maintain homeostasis (physiological balance). When continued stress is induced, internal processes adapt to return the biological organism to homeostasis (balance). So MORE stress of the same stressor is required to effect the initial elicited response when the stress was first applied all those doses ago.
It's a beautiful function of biological organisms. But it sucks for recreational drug use.
Doses administered close enough together provide a synergistic response to the applied stress. That is the initial dose (stressor) is essentially increased as the first neurophysiological response is still reacting when the second dose (stressor) is administered compounding the first response.
Tolerance is adaptation. A gift in most instances, but a curse to recreational drug users. We (humans) physiologically adapt to applied (increased) stress. Medication applies an exogenous (and endogenous through chemical reaction) stress eliciting a neurophysiological response (pain relief, sedation, euphoria, etc). The biological organism (us) is programmed to maintain homeostasis (physiological balance). When continued stress is induced, internal processes adapt to return the biological organism to homeostasis (balance). So MORE stress of the same stressor is required to effect the initial elicited response when the stress was first applied all those doses ago.
It's a beautiful function of biological organisms. But it sucks for recreational drug use.
Swimmingdancer
Bluelight Crew
^Great explanation 