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Kicking Coke - Best Meds?

It shouldn't be hard to find desoxypipradol. It's pretty available, I figure everyone figures it's outside the analogue act.
 
Ham-milton said:
It shouldn't be hard to find desoxypipradol. It's pretty available, I figure everyone figures it's outside the analogue act.
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At a glance - it looks benign.
As with any such things caution is in order.

MY personal ideal would NOT be a substance for chronic use so much as a bridge to taper off of...
I guess the drug companies only show interest in chronic treatments.
 
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fastandbulbous said:
If pushed, I'd have said that pipradrol (note not desoxypipradrol, although it might be of some use) might have been a good bet.
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Can you explain why you believe pipradrol would be more effective?
 
Is there a reason for the preference for deprenyl patch?

It is an irreversible inhibitor so a constant dose in the bloodstream is not really a problem - once the MAO-B's get killed they are only slowly re-synthesized. Rasagilene/Azilect is another option if you are really worried about non-specific side effects - it's more selective but it's also a lot more expensive.

As for dopamine agonists, the sleepiness is very dose-dependent and varies quite a bit with the individual. For Parkinson's treatment, the doses can get pretty high but at lower doses and occasional use, sleepiness may not be a problem for you. At the low end of Parkinson's doses less than 1/4 of users complained of excess sleepiness for pramipexole/Mirapex so YMMV. (I tried a mg once and it didn't make me sleepy)
 
Groovy guru said:
Is there a reason for the preference for deprenyl patch?
Click to expand...

Come to think of it - I was biased by a persuasive study done by the manufacturer - claiming a better safety profile!

I think deprenyl is a fine idea. My general caution is that drugs of abuse aside - I eat high dose Prozac + Welbutrin + T3 for depression. While I can lay off the T3 and Welbutrin while abusing - you can see that I am walking a dangerous line!

I need off the coke - safe and temp. help for W/D - and back on to my helpful meds.
Even ultra low dose, selective MAOI's are a bit more than I am willing to hazard...
Were I off the 'butrin, T3 and stims. I might give it a try. When clean - the above AD trio works well.

Thanks!

wz
 
Well, I see why you are so cautious with MAOIs.

It's hard to assess the effects of the selective ones since the drug companies aren't going to risk lawsuits. My wife has been taking rasagilene for quite some time and we've found none of the dietary restrictions applied and actually, we haven't seen any side effects at all. At 1 mg/day there *might* have been potentiation of pseudoephedrine (not sure - we were pretty hyper about these things at the beginning) but not at the 0.5 mg/day she's taking now.

But, I certainly do understand not wanting to take the chance combining it with SSRIs.

I think the pramipexole option is viable. She used to take that and Zoloft (the Zoloft didn't do anything for her). Initially when we were titrating up, there wasn't a problem with sleepiness though later at 3mgs/day it became a problem especially after a drink or two. It's pretty much a personal thing wrt the side effects - for her at higher doses it made the depression worse - but some people find the opposite. And there are trials on using pramipexole to help cocaine addiction to get approximate doses.

Good luck!
 
Personally I find Gabapentin and some sort of dopamine supplement like L-tyrosine or L-dopa (can be found in stores as Macuna plant extracts) to help. A lot of the things named are difficult to find.

Coke craving are a result of lowered dopamine levels.Give it about 3 days and you'll be better. Eats lots of protein and your veggies. Believe me i've been through this a lot...

Oh also, theres a supplement called NADH which supposedly raises tyrosine hydroxylase levels through some goofy way. I've been using it and feeling heaps better.

Pm me if you really need help...
 
There's lots of tyrosine in cheese. I'm on bupropion for coke repair. I started it a few months ago. I've been clean for a month. It doesn't work. I don't feel anything. I don't enjoy anything. Every day gets worse. There's nothing I can do about it. I never got my appetite back. Needless to say, I did too much too long. Maybe I'll ask the doc about modafinil.
 
There's a drug called atomoxetine that is sometimes given to ADHD people instead of ritalin. It's from the same chemical family of compounds as fluoxetine although it works as a NARI and not SSRI.

Interestingly, this whole family of compounds is derived from an antihistaminergic background. This could help account for why, although atomoxetine is a NARI, it says on Wikipedia that "Users should expect to feel tired and groggy for a few weeks." This is important, since a barrier to the clinical acceptance of drugs with a noradrenergic tone is increased incidence of hypertension. This shows that it is possible to disassociate the two.

^^^I think for kicking coke though, you'll have to consider some kind of dopaminergic, not noradrenergic.
 
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Definetly selegiline, it helped me kick a raging methamphetamine and dexamphetamine habit. I am on nardil right now and finding that great for my general social phobia and anxiety issues. Maybe taking that would help because you know that if you relapse, you will die. Hell of a motivation to stay clean
 
Untreated Depression Kills!

adrefofadre said:
There's lots of tyrosine in cheese. I'm on bupropion for coke repair. I started it a few months ago. I've been clean for a month. It doesn't work. I don't feel anything. I don't enjoy anything. Every day gets worse. There's nothing I can do about it... Maybe I'll ask the doc about modafinil.
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This is NOT cool!
Depression is lethal.

MAKE your doctor read a study called STAR-D.
T-3 is highly effective.

You need to get your doc to add another anti-depresant or up the wellbutrin.
(modafinil is not strong enough)

If you are craving, consider low dose naltrexone.

PM me if you must - DO NOT GIVE UP!?

(Up to 400 mg wellbutrin / day have been used - just be very careful of seizures.)

How much are you on now?

Please hang in and let us know?


WZ
 
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Untreated Depression Kills!

Middleway said:
Definetly selegiline, it helped me kick a raging methamphetamine and dexamphetamine habit. I am on nardil right now and finding that great for my general social phobia and anxiety issues. Maybe taking that would help because you know that if you relapse, you will die. Hell of a motivation to stay clean
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What selegiline dosing were you finding effective?

(WARNING - do not mix any MAOI with wellbutrin or coke!!)

If you can stand the restrictions and side effects, nardil IS great for depression and SP.

Question - do you think nardil alone could have broken the speed addiction?

For depression - if you have insurance - selegiline patch is worth trying VS welbutrin!

Doctors don't know s--t about T-3 augmentation.
For your life's sake - EDUCATE them!
(STAR-D)


WZ
 
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Smyth said:
There's a drug called atomoxetine that is sometimes given to ADHD people instead of ritalin.
^^^I think for kicking coke though, you'll have to consider some kind of dopaminergic, not noradrenergic.
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IMHE - Atomoxetine SUCKS! ;)

Now Amineptine - that would rock
 
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I didn't read any of this, but an obvious solution would be switch to methylphenidate and taper, since it acts pretty much similar to cocaine and lasts way much longer.
 
For a really short term solution, yeah, but that's not the goal. Long term abstinence is.
 
Ham-milton said:
For a really short term solution, yeah, but that's not the goal. Long term abstinence is.
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Thanks for understanding both my long and short term goals!

Fortunately, I have always hated stimulants - other than cocaine and methylxanthines.

I am IN NO WAY some kind of 12 Step Type!
All I know is that coke 'Got Me'.
Total abstinence may be required.

I can get Adderall SR or Rit.
I just do not like or want them!
In fact - rit does nothing for me.

Now - NO stimulant is as fun as potent guarana extract in a frozen chocolate coffee! =D

WZ

PS FWIW - I hate isolated caffeine is no fun for me...
Something about the synergistic blend of alkaloids in the brew is astonishing!
 
If you can stand the restrictions and side effects, nardil IS great for depression and SP.

Question - do you think nardil alone could have broken the speed addiction?
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Considering how many people here on BL take very little notice of drug interaction warnings, I think Nardil(phenelzine) would be a hypertensive crisis just waiting to happen for most people. You cannot fuck around with the non-competetive MAOIs like phenelzine or tranylcypromine, but some people would just have the attitude,"well it says in medical books that you're not supposed to take opioids & CNS depressants together, but I have & I was OK".

I'm glad it's working for Middleway, but he seems to understand that with that particular treatment, relapse = trip to hospital (& possibly a horribly painful death) - not something you can expect from everyone
 
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