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N&PD Moderators: Skorpio
Ketamine salts solubility
- Thread starter fastandbulbous
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AlsoTapered
Bluelighter
I never claimed it was a new compound and actually included hotlinks to the references.
I am simply attempting to provide anyone interested with ALL the hotlinks I have access to so that they can study the various classes of opioid.
Sorry for the late response, I missed your post.
BTW elsewhere I have repeatedly stated that hugely potent opioids are extremely dangerous. Many people still rely on eyeballing doses so anything more than about ten times morphine in potency carries the extreme risk of overdose. When you reach compounds like carfentanil that are now on the street, it's reaching the limits of dilution when in a solid format. There are ways but it's not much of a surprise to realize that such compounds, compounds which find legitimate use in veterinary are produced as solutions.
It's also worth noting that potency varies between individuals and so while the press is keen to list carfentanil as x10000 morphine, the variability can be quite massive. It's a known issue within the field of anesthesia.
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Bluelighter
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A_REAL_ASS_KICKER
2-(4-methoxyphenyl)-1-aminocyclohexane
FASTER_PUSSYCAT
N-allyl-2-phenyl-1-aminocyclohexane
HARVARD
N,N-di-allyl-lysergamide
BILLY
2-(4-methylphenyl)-1-methylaminocyclohexane
YANA
1-(3,4-methylenedioxyphenyl)-4-aminocyclohexaneLast edited:
AlsoTapered
Bluelighter
Above is a link to a fantastic paper which not only comprehensively documents the QSAR of every cocaine homologue documented, but it also correctly identifies the fact that methylphenidate and mazindol which chemically distinct, produce psychostimulation via the same pathways.
The other major class of psychostimulants are the amphetamines but people sometimes don't recognize that desoxypipradrol and homologues, nomifensine and homologues and various other stimulants such as fencamfamine (and homologues), phenmetrazine (and homologues) and even the 1,2-diaryl-2-amino-ethan-1-one derivatives all contain within them the alpha methyl phenylethylamine (amphetamine) scaffold within them*.
*In a few examples the benzene ring is replaced by other aromatic rings but such a modification appears to universally reduce activity.
AlsoTapered
Bluelighter
Is it a kappa agonist?
A good question. The thing is, diprenorphine (M-5050) was discovered in 1965 as part of Dr. Kenneth W. Bentley's extensive QSAR study of the ethenomorphinans which he and his team began studying in 1962 and which are generally referred to as 'Bentley compounds'.
What I've just noted is that it was a Belgian researcher who decided that applying the Diels-Alder reaction to as many natural compounds as they could think of. Obviously nature is a great source of dienes and so thebaine and oripavine were interesting targets as a decade before US researchers had noted that modification of the C-ring in phenanthracene opioids could significantly increase activity.
What it's important to know is that what Bentley was originally seeking was a cheaper alternative to codeine specifically for use in compound analgesics such as co-codamol. After all, if one could replace 8.4mg of codeine phosphate with, say, 1μg of etorphine (M-99), at scale it would prove to be a worthwhile saving. Obviously the logic was that being compound analgesics, the paracetamol would stop someone from simply eating a whole box full of tablets...
But of course he was disappointed that very few of the compounds discovered were active orally. In fact it was 7-PET and not etorphine that ended up being the candidate but by that point it was recognized that people had worked out how to extract the codeine from co-codamol and the same technique would have allowed 7-PET to be extracted and that would not be a good thing.
I believe a lab accident in 1965 in which almost the entire team were accidentally poisoned by one of the more potent homologues that meant that someone in the team decided that finding an effective antidote was an important task and diprenorphine had displayed the most potent antagonist activity of the series.
I feel it's a terrible loss that their is almost no record of the events surrounding the discovery and development of these compounds. Snippets have been written including how buprenorphine was tested - members of the team were used as subjects which is when they discovered that nausea and vomiting were a particular issue.
It's worth noting that etorphine is always supplied with an equal amount of diprenorphine to treat accidental poisonings. In nations where carfentanil is used to sedate large animals... diprenorphine is also supplied as a treatment for such accidents.
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Bluelighter
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- Oct 20, 2008
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U4EUH
5-phenyl-2-amino-4,5-dihydro-3-aza-4-methylfuran
MUFFIN
5-phenyl-2-amino-4,5-dihydro-3-aza-4-methylthiophene
RALPH
5-phenyl-2-amino-3-aza-4-methylcyclopent-2-ene
MOSS
5-(4-methoxyphenyl)-2-amino-3-aza-4-methylcyclopent-2-ene
STERLING
5-(4-methylphenyl)-2-amino-3-aza-4-methylcyclopent-2-ene
BUTTERS
5-(3,4-methylenedioxyphenyl)-2-amino-3-aza-4-methylcyclopent-2-ene
CARMEN
4,5-dihydro-5-(3,4-methylenedioxyphenyl)-2-amino-3-aza-4-methylthiophene
PANCHO
4,5-dihydro-5-(4-methoxyphenyl)-2-amino-3-aza-4-methylthiophene
LEFTY
4,5-dihydro-5-(4-methylthiophenyl)-2-amino-3-aza-4-methylthiophene
DEXTER
4,5-dihydro-5-(4-methylphenyl)-2-amino-3-aza-4-methylthiophene
TERRA_INCOGNITA
4,5-dihydro-5-(3,4,5-trimethylphenyl)-2-amino-3-aza-4-methylthiophene
BERSERKEN
4,5-dihydro-5-(2,5-dimethoxy-4-bromophenyl)-2-amino-3-aza-4-methylthiophene
BOYSENBERRY
4,5-dihydro-5-(2,5-dimethoxy-4-methylphenyl)-2-amino-3-aza-4-methylfuran
For All I Know, This Series Is As Toxic As Anything.Last edited:
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Bluelighter
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JAIME_SETH_EVANS_TROXLER
1-phenyl-1-(methylthio)-2-methylaminopropane
He's A Smooth Operator!
JIM_AARON_BAAL_EMORY
1-(3,4-methylenedioxyphenyl)-1-(methylthio)-2-methylaminopropane
Think Applebee's.
CH2=CH-CH2-S-CH2CH=CH2
ALLICIN_WONDERLAND
diallylsulfide
Antimicrobial found in Garlic.
Wards off vampiristas.
May be an anesthetic gas.Last edited:
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Bluelighter
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ALFRED_NOBEL
N-(2,2-dichloroacetyl)-1-(2,5-dimethoxy-4-nitrophenyl)-1-hydroxy-3-oxo-2-aminopropane
Oral antibiotic (ring activated chloramphenicol analog).
Plan B:
ALEXANDER_FLEMING
N-(2,2-dichloroacetyl)-1-(2,5-dimethoxy-4-nitrophenyl)-1-amino-3-oxo-2-aminopropane
KING_ANDRIEUX_THE_X
1-(3,4-methylenedioxyphenyl)-2-methylamino-1,3-dioxopropane
I was looking for a robust antibiotic with recreational and anti-Parkinson characteristics. Don't know what I found.Last edited:
AlsoTapered
Bluelighter
Ugi reaction for the synthesis of 4-aminopiperidine-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil
Tetrahedron Letters 2010-jun vol. 51 iss. 22, 2010
Author(s): Sandra Malaquin; Mouhamad Jida; Jean-Claude Gesquiere; Rebecca Deprez-Poulain; Benoit Deprez; Guillaume Laconde
Library Genesis
libgen.li
Anyone wondering why carfentanil is now becoming common on the streets of North America need look no further. It's worth noting that the scope of the synthesis allows for the pendent benzene to be swapped for other aromatics AND the inclusion of a beta-hydroxy moiety which renders the products 6-8x more potent.
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Bluelighter
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BETHEL
1-(3,4-dimethylphenyl)-1-methoxy-2-propylaminopropane
OINKOS
N-allyl-1-(indole-3-yl)-2-aminopropane
TRICKY
1-phenyl-1-oxo-2-diallylaminopentane
MASSIVE_ATTACK
1-(3,4-methylenedioxyphenyl)-1-oxo-2-diallylaminopent-4-ene
ALL_THE_MONEY_IN_THE_WORLD / A_KING'S_RANSOM
N-allyl-2-carbomethoxy-3-phenylcarbonyloxy-8-azabicyclo[3.2.1]octaneLast edited:- Status
