• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

Ketamine salts solubility

Status
Not open for further replies.
pubchem.ncbi.nlm.nih.gov

(1R,5S)-9-methoxy-9-phenyl-3-(2-phenylethyl)-3-azabicyclo[3.3.1]nonane

(1R,5S)-9-methoxy-9-phenyl-3-(2-phenylethyl)-3-azabicyclo[3.3.1]nonane | C23H29NO | CID 21151698 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov

BTW the above compound is an example of an opioid demonstrated to be over x100,000 morphine in potency.

If one has access to ChemOffice, it's worth overlaying the above compound with fentanyl, BDPC and similar compounds. The above compound hasn't seen optimization such as replacing the beta-aromatic with a 2-thienyl or 2-furanyl moiety or the addition of a chiral beta-hydroxy moiety.

But in a PM the Canadian BLer noted that researchers used OHMEfentanyl as a reference compound and were shocked to discover that even after 3 applications of OHMEfentanyl, the compound was not dislodged from the MOR receptors.

When we reach these levels of potency, Ki values are not measured in micromoles (uM) but rather in nanomoles (nM). I have mistakenly read affinity data ASSUMING the values were in uM only to discover upon closer examination that the values were in nMs.

The paper 'A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-hydroxy)phenylmorphans'

Although the above paper ostensibly discusses antagonist, it's important to note that opiate ligands which display antagonist activity MUST include a meta-hydroxy moiety on the alpha aromatic (benzene) ring or bioisostere thereof.
 
^ not a new compound at all. However the potency in vivo is nowhere near as high as is suggested by in vitro. ED50 32ug/kg in guinea pigs. In humans it is not that potent (fentanyl level potency)
Patent is 1972 to Sanko company, Chem Pharm Bull (Japan) 2050-2057 (1970)

I don't understannd this obsession with in vitro potency over everything, are you playing some kind of smackhead top trumps?

Safer opioids would be a good thing and super potent /= safer
Dezocine based compounds with reduced respiratory depression and or ceiling effect would be a better approach if harm reduction really was your priority
 
1-(3,4-dichlorophenyl)-1-oxo-2-(1-pyrrolidinyl)-pentane.png


MEANIE_GREENY
1-(3,4-dichlorophenyl)-1-oxo-2-(1-pyrrolidinyl)-pentane
 
1-phenyl-2-methylaminopropane%20saccharate.png


1-phenyl-2-methylaminopropane saccharate

50:50 Mix With

1-phenyl-2-methylaminopropane%20aspartate.png


MIXED_TREAT
1-phenyl-2-methylaminopropane aspartate

1-phenyl-2-ethylaminopropane%20saccharate.png


1-phenyl-2-ethylaminopropane saccharate

50:50 Mix With

1-phenyl-2-ethylaminopropane%20aspartate.png


1-phenyl-2-ethylaminopropane aspartate

N-ETHYL
1-phenyl-2-ethylaminopropane saccharate

1-(3,4-methylenedioxyphenyl)-2-methylaminopropane%20gluconate.png


MDG
1-(3,4-methylenedioxyphenyl)-2-methylaminopropane gluconate
 
Last edited:
3-(methanone-1-yl)indole.png


3-(methanone-1-yl)indole

1-(indole-3-yl)-2-nitroethene.png


1-(indole-3-yl)-2-nitroethene

Then Tryptamine, Then DMT.

3-allyl-indole.png


3-allyl-indole

3-(1-oxo-ethane-2-yl)indole.png


3-(1-oxo-ethane-2-yl)indole

Then DMT Using Dimethylamine.
 
Last edited:
Without posting a structure, it's really hard to picture all that.

1-(furan-2-yl)-2-methylaminopropane.png


FURIOUS_GEORGE
1-(furan-2-yl)-2-methylaminopropane
 
1-phenyl-1-oxo-2-(2-azaindan-2-yl)pentane.png


HUCKEL
1-phenyl-1-oxo-2-(2-azaindan-2-yl)pentane

1-phenyl-1-oxo-2-(1,1,3-trioxo-1-thia-2-azaindan-2-yl)pentane.png


BITTER_SWEET
1-phenyl-1-oxo-2-(1,1,3-trioxo-1-thia-2-azaindan-2-yl)pentane

1-(3,4-methylenedioxyphenyl)-2-(1,1,3-trioxo-1-thia-2-azaindan-2-yl)propane.png


SYMPHONY
1-(3,4-methylenedioxyphenyl)-2-(1,1,3-trioxo-1-thia-2-azaindan-2-yl)propane

N-methyl-5,6-methylenedioxy-1H-1%ce%bb6,2-Benzothiazole-1,1,3(2H)-trione.png


DESIGNER_SACCHARIN
N-methyl-5,6-methylenedioxy-1H-1,2-Benzothiazole-1,1,3-(2H)-trione

1-(indole-3-yl)-2-(2-azaindan-2-yl)ethane.png


SUENOS_DOLCES
1-(indole-3-yl)-2-(2-azaindan-2-yl)ethane

1-(indole-3-yl)-2-(2-azaindan-2-yl)-1-oxopentane.png


RICO_SUAVE
1-(indole-3-yl)-2-(2-azaindan-2-yl)-1-oxopentane

1-(1-pentyl-indole-3-yl)-2-(2-azaindan-2-yl)-1-oxopropane.png


CHEECH_n_CHONG
1-(1-pentyl-indole-3-yl)-2-(2-azaindan-2-yl)-1-oxopropane
 
Last edited:
3-(furan-2-yl)-3-(2-pyrrolidinyl)-acetone.png


ENIGMAGICAL
3-(furan-2-yl)-3-(2-pyrrolidinyl)-acetone
3-(thiophen-2-yl)-3-(2-pyrrolidinyl)-acetone.png


AMAIZEING
3-(thiophen-2-yl)-3-(2-pyrrolidinyl)-acetone

1-(furan-2-yl)-2-aminopropane.png


BRIDGES_OF_DOPE
1-(furan-2-yl)-2-aminopropane

1-(furan-2-yl)-2-ethylaminopropane.png


ERIS
1-(furan-2-yl)-2-ethylaminopropane

N-allyl-1-(furan-2-yl)-2-aminopropane.png


AVID_DIVA
N-allyl-1-(furan-2-yl)-2-aminopropane

N-allyl-1-(4-methylthiophen-2-yl)-2-amino-1-oxopropane.png


INSATIABLE_INSURRECTION
N-allyl-1-(4-methylthiophen-2-yl)-2-amino-1-oxopropane

1-(4,5-dimethylfuran-2-yl)-2-methylaminopropane.png


THE_VALIANT_VIKINGS
1-(4,5-dimethylfuran-2-yl)-2-methylaminopropane

1-phenyl-2-(2-oxo-3-oxacyclopentylamino)propane.png


G's_UP_HOES_DOWN
1-phenyl-2-(2-oxo-3-oxacyclopentylamino)propane

N-(tert-butyl)-1-phenyl-2-aminopropane.png


SID_CAESAR
N-(tert-butyl)-1-phenyl-2-aminopropane

1-phenyl-2-isopropylaminopropane.png


JOY
1-phenyl-2-isopropylaminopropane

3-phenyl-2-oxo-3-(2-piperidinyl)propane.png


DES-O-MPH
3-phenyl-2-oxo-3-(2-piperidinyl)propane

Like Methylphenidate [MPH] sans the O in the MeO portion of Ritalin's carbomethoxy (R-(C=O)-O-CH3) functional group.

 
Last edited:
1-(4-methoxyphenyl)-1-oxo-N,N-diethylaminopentane.png


ELLEN
1-(4-methoxyphenyl)-1-oxo-N,N-diethylaminopentane

1-(3,4-methylenedioxyphenyl)-1-oxo-N-ethylaminopentane.png


STORMY
1-(3,4-methylenedioxyphenyl)-1-oxo-N-ethylaminopentane

1-phenyl-1-oxo-N-ethyl-N-hydroxyaminopentane.png


HELEN_"MAMA FAYE"_KITCHENS_MCNAIR
1-phenyl-1-oxo-N-ethyl-N-hydroxyaminopentane

 
Last edited:
1-phenyl-2-aminopropane.png


AMP by Lazaru circa 1887
1-phenyl-2-aminopropane; phenylisopropylamine; AlphaMethylPHenylEThylAMINE or amphetamine.

The compound that started it up!

N-hydroxy-1-(4-methoxyphenyl)-2-methylamino-propane.png


PERSPICACIOUS_PERSEUS
N-hydroxy-1-(4-methoxyphenyl)-2-methylamino-propane

N-hydroxy-1-(3,4-methylenedioxy-5-methoxyphenyl)-2-aminopropane.png


PAN_HORUS
N-hydroxy-1-(3,4-methylenedioxy-5-methoxyphenyl)-2-aminopropane

Featuring The All-Seeing Eye Of Newt!

Barely Legal!!!
 
Last edited:
1-(1-oxocyclopent-2,4-diene-3-yl)-2-methylaminopropane.png


SONIC_THE_HEDGEHOG
1-(1-oxocyclopent-2,4-diene-3-yl)-2-methylaminopropane

CHECKPOINT!
 
There are an estimated 10^60th power of chemical compounds. Only 2% of them have been characterized so far.

I focus on dopamine, adrenaline, and serotonin analogs, using Sasha Shulgin's methodology as illustrated in PiHKAL & TiHKAL.
 
Last edited:
N-(1-methylpiperidine-4-yl)-aniline.png


POOR_MAN'S_FENTANYL
N-(1-methylpiperidine-4-yl)-aniline

4-phenyl-4-(2-piperidinyl)-3-oxobutane.png


HYATT_WYATT
4-phenyl-4-(2-piperidinyl)-3-oxobutane

4-phenyl-4-(1-methyl-3-piperidinyl)-3-oxobutane.png


DOPER_ROPER
4-phenyl-4-(1-methyl-3-piperidinyl)-3-oxobutane
 
Last edited:
Status
Not open for further replies.
Top