Ketamine salts solubility

[AlsoTapered]

I've written a post describing a ligand design process that is only 5 steps. Read it, learn it, understand it, use it then post it.

 

[Rectify]

Oh, I thought you had actual data.

 

[AlsoTapered]

I do - because I did exactly what I said I did in the post.

 

[Rectify]

Link?

Ok, so I ran a search on the 1st thing to come to mind, and one of my favorite chemicals, @ PubMed

JESUS_OF_NAZARETH
1-(3,4-dichlorophenyl)-2-methylaminopropane

No exact matches. Nada. Zip. Zero. Zilch.

ADRENALINE
1-(3,4-dihydroxyphenyl)-1-hydroxy-2-methylaminoethane

"I'll Do Whatever It Takes Cuz I Love The Adrenaline In My Veins. You Take Me To The Top I'm Ready For Whatever It Takes."--Imagine Dragons.

 

[Rectify]

SHAY
7-(1-methylpiperidine-4-yl)-1,3-dimethylxanthine

INVERSE_CAPTAGON
8-(2-aminopropyl)-1,3,7-trimethylxanthine

 

[Skorpio]

I don't think aldehyde adducts of LSA will be stable enough to reach the brain.

 

[SpiralusSancti]

https://www.shroomery.org/forums/showflat.php/Number/27850299/fpart/13

pic: I will post my bottle of isovaleraldehyde when I am back in town 2 weeks from now. But this is the aldehyde that will give you real LSD like effects and stimulation, 2 drops is all you need. Isovalderaldehyde has nearly the exact same chemical formula as the tail end of DMT or psilocin: CHO CH2 CH2 2(CH3), and nearly the same molecular weight 87g/mol as LSD's diethylamine at 73 g/mol. Both isovaleraldehyde from the Greece Eleusis kykeon peppermint and 3-aminopentane from Dr. Nichols have exactly 5 carbon groups and 11 hydrogen groups (once the aldehye attaches to one of the H already at the amide of LSA). Very similar to LSD's diethylamine which has 4 carbon groups and 11 hydrogen groups. See post above with the pics and study from LSD scientist Dr. Nichols as to why Rats respond to this number of carbons and hydrogens on the LSA amide as if it is real LSD.

This is ANCIENT LSD, it was hypothesized to form from ground claviceps paspali ergot which grows on paspalum distichum grass in the famous Rarian plane adjacent to Eleusis (same safe alkaloid profile as Mesoamerican morning glory high in LSA) that is mixed with a handful or large amount of fresh peppermint leaves for a while in wine. This could very well be the famous Kykeon psychedelic brew, formula kept secret for 2,000 years by the priests, able to easily feed over 300 hundred people (new initiates) like clockwork every Sept. LSA --> potent LSI, it is indeed possible and works extremely well.

You say you are advanced chemist and than proceed to make statements that are similar to – coke and sugar have almost the same formula so therefore they are both addictive.

I’m not saying you are lying to be advanced chemist but your reasoning is becoming idk..

 

[AlsoTapered]

Protecting the N of the indole system with isovaleraldehyde is known, it's a way to produce a legal LSD prodrug but a quick look at the MSDS of the compound and checking the PubChem references strongly suggest that the OP isn't too clear on what features are key to the activity of LSD (and homologues.

KEY is the fact that it contains the DMT molecule within it's structure.

I'm always impressed by people who are at the peak of the Dunning-Kruger effect. IF such a simple, commercially available compound really was a substitute for LSD, I'm quietly confident that it wouldn't turn up on a BBS devoted to mushrooms. Although, 'kept in the dark and fed shit' is an apt definition of both.

 

[AlsoTapered]

Title: Synthese basisch substituierter, analgetisch wirksamer Benzimidazol-Derivate
Series: Cellular and Molecular Life Sciences 1957-oct vol. 13 iss. 10
Author(s): A. Hunger; J. Kebrle; A. Rossi; K. Hoffmann
Year: 1957

Above is the paper which has the chiral benzaldehyde that increases the potency of the nitazine class by a factor of 4.

I think it important to remember that animal models aren't always accurate. BDPC was originally listed as being >x10000 morphine but in man, it's x527. I have read the human trial of etonitazene (for the purposes of opiate detoxification) and orally, it was shown to be x60 morphine and so I suggest that example 5 (with the chiral carboxamide) is some x240 morphine.

Now I cannot speak for others, but I consider x240 M to be MORE than sufficient.

Of course nations will ban the whole scaffold... and THEN people will struggle to find a compound similar to fentanyl in potency and synthetic complexity.

It may NOT be x4 more potent in preventing abstinence syndrome because the carboxamide increases NOP affinity.

 

[AlsoTapered]

Link? https://bluelight.org/xf/threads/a-how-to-guide-on-drug-discovery.931307/

Now read it, understand it, USE it. There goes 98% of your posts.

 

[Rectify]

Yes, but those 2% are golden.

 

[Rectify]

PubChem, Zero Results Found. Am I Doing This Right?

STELLA
1-(3,4-dioxocyclohexyl)-2-ethylaminopropane

Again, Zero Results Found.

ELYSE
1-(2,5-dioxo-4-(cyclopropylmethyl)cyclohexyl)-2-aminopropane

PubChem Did Find This Next One, So I Won't Name It, But I Didn't Find Any Reports About Its Bioactivity.

C1(CCCCC1)C(C1NCCCC1)C(=O)OC

1-cyclohexyl-1-carbomethoxy-1-(2-piperidinyl)methane

 

[Rectify]

LONG_LASTER
1-(2,6-dimethylphenyl)-2-isopropylamino-propane

SUPER_UBER_MENSCHE_LYFT
1-(4-methoxyphenyl)-2-isopropylaminopropane

ETHOS
1-(4-ethoxyphenyl)-2-aminopropane

SWUFT
1-(5-cyclopropyloxyindole-3-yl)-2-dimethylaminoethane

DAREDEVIL
1-(4-(cyclopropylmethylthio)-2,5-dimethoxyphenyl)-2-aminopropane

O,O-diethyl-morphine
GODSMACK

 

[AlsoTapered]

European Journal of Medicinal Chemistry vol. 23 iss. 6 pp.511—515 Synthesis and pharmacological investigation of the 3-analogs of viminol DOI: 10.1016/0223-5234(88)90093-1 a a	Marco de Amici; Carlo de Micheli; Fabio Platini; Davide Della Bella; Ida Caramazza		1988 Novembre		French;English
	Pharmacological Research Communications vol. 8 iss. 2 pp.111—126 Absolute configuration and biological activity of viminol stereoisomers DOI: 10.1016/0031-6989(76)90001-1 a a	D. Della Bella; G. Benelli; A. Sassi		1976 April
	Pharmacology Biochemistry and Behavior vol. 20 iss. 1 pp.59—62 The discriminative stimulus properties of the R2 isomer of viminol DOI: 10.1016/0091-3057(84)90101-1 a a	Jennifer E. Shook; Mary Jeanne Kallman; William L. Dewey		1984 January		English
	Acta Crystallographica Section B Structural Crystallography & Crystal Chemistry (International Union of Crystallography) vol. 31 iss. 6 pp.1576—1581 The crystal and molecular structure of the analgesic [S(R,R)]-viminol; [αS(R,R)]-α-[(di-s-butylamino)methyl]-1-(2-chlorobenzyl)-1H-2-pyrrolemethanol p-hydroxybenzoate DOI: 10.1107/s0567740875005717 a a	Silverton, J. V. ;Lloyd, H. A.		1975 June 15
	European Journal of Pharmacology vol. 23 iss. 2 pp.137—146 Some behavioral and EEG effects of a new analgesic agent (viminol) in comparison with morphine in rats DOI: 10.1016/0014-2999(73)90049-6 a a	M. Babbini; M. Gaiardi; M. Bartoletti		1973 August		English
	Life Sciences vol. 17 iss. 1 pp.73—74 Viminol stereoisomers and lamina V interneurons activity: Preliminary results DOI: 10.1016/0024-3205(75)90238-6 a a	Davide Della Bella; Giancarlo Benelli; Jean-Marie Besson		1975 July		English
	Journal of Substance Use vol. 12 iss. 4 pp.301—305 Dependence on Viminol DOI: 10.1080/14659890701237124 a a	Turkiewicz, G.; Baltieri, D. A.		2007 January		English
	ChemInform vol. 20 iss. 19 ChemInform Abstract: Synthesis and Pharmacological Investigation of the 3-Analogues of Viminol. DOI: 10.1002/chin.198919183 a a

Bioorganic & Medicinal Chemistry Letters vol. 5 iss. 6 pp.589—592 Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective μ-opioid analgesic DOI: 10.1016/0960-894x(95)00077-7 a a	M. Napoletano; Bella D. Delia; C. Fraire; G. Grancini; C. Masotto; S. Ricciardi; C. Zambon		1995 March		English
	ChemInform vol. 26 iss. 31 pp.no—no ChemInform Abstract: Stereoselective Synthesis and Evaluation of All Stereoisomers of Z4349, a Novel and Selective μ-Opioid Analgesic. DOI: 10.1002/chin.199531209 a a

Above are all the papers covering Viminol derivatives including Z4349 which is x318 M in potency

 

[AlsoTapered]

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	ChemInform vol. 33 iss. 11 pp.no—no ChemInform Abstract: New μ-Opioid Receptor Agonists with Piperazine Moiety. DOI: 10.1002/chin.200211149 a a	Teruo Komoto; Tomomi Okada; Susumu Sato; Yasuhiro Niino; Tetsuo Oka; Takao Sakamoto		2010 May 22
	Journal of Computer-Aided Molecular Design vol. 7 iss. 5 pp.557—571 Computer-aided structure-affinity relationships in a set of piperazine and 3,8-diazabicyclo[3.2.1]octane derivatives binding to the μ-opioid receptor DOI: 10.1007/bf00124362 a a	Daniela Barlocco; Giorgio Cignarella; Giovanni Greco; Ettore Novellino		1993 October		English
	Journal of Theoretical and Computational Chemistry vol. 09 iss. supp01 pp.49—63 INTERACTION OF BRIDGED PIPERAZINE DERIVATIVES WITH THE μ-OPIOID RECEPTOR — A THEORETICAL MODEL DOI: 10.1142/S0219633610005566 a a

All of the piperazine opioids from AP-237 to MT-45 to Azaprocin.

 

[sekio]

See post above with the pics and study from LSD scientist Dr. Nichols as to why Rats respond to this number of carbons and hydrogens on the LSA amide as if it is real LSD

It's not the number of atoms that matter, it's their connectivity and shape.
The 5HT2a receptor (active site fot LSD) basically needs a diethylamide or sometthing closely approximating its shape, i.e. 3-pentylamide or dimethylazetizide. Anything bigger doesn't fit.
Take a look at the paper where they detail the structure of the 5HT receptor and how LSD binds.
Also, there is no evidence that anything bigger tjan N-ethyl-LSA has any activity.

Both isovaleraldehyde from the Greece Eleusis kykeon peppermint

Isovaleraldehyde is definitely not related to peppermint. I used to work with the stuff. It smells like toe jam.

This is ANCIENT LSD, it was hypothesized to form from ground claviceps paspali ergot which grows on paspalum distichum grass in the famous Rarian plane adjacent to Eleusis (same safe alkaloid profile as Mesoamerican morning glory high in LSA)

The problem is, ergot doesn't make LSA. It makes ergolines (e.g. ergotamine), which need to be chemically processed to split out the lysergic acid. And morning glory / Hawaiian baby woodrose have a totally different alkaloid profile - I don't think they make any ergolines.

How are you going to isolate workable amounts of LSA anyway? Attempting to do chemistry on crude mixtures is a recipe for frustration.

Also, did you know that aldehydes and amines do not produce N-alkylamines - they produce imines (and water), which in the presence of water will revert to the aldehyde and the amine. In order to actually produce useful amounts of imine you would need to work in an anhydrous solcent and add something to bind or react with the water formed. However as soon as you ingested your imine it would break back apart.
To actually make N-isovaleryl-lysergic acid amide you would need to form the imine and then add a reducing agent like sodium borohydride.

Otherwise you will end up with morning glory seeds (or ergot) that reeks of toejam and is not any more active than usual.

 

[Rectify]

AZAZEL
1-phenyl-2-isopropylaminopropane

MICHAEL
1-(3,4-methylenedioxyphenyl)-2-isopropylaminopropane

RAPHAEL
1-(4-methoxyphenyl)-2-isopropylaminopropane

KATHY
1-(4-methylphenyl)-2-isopropylaminopropane

JOHN
1-(3,4-dichlorophenyl)-2-isopropylaminopropane

MARK
1-(3,4-dibromophenyl)-2-isopropylaminopropane

 

[Rectify]

This N-isopropyl amphetamine series has me tickled pink! Day 2.

 

[Rectify]

Day 3

BENZE_NEXT
1-(3,4-dimethylphenyl)-2-isopropylaminopropane

Danke!

 

[sekio]

You're still at this?
Jesus man. Time to learn some pharmacology already...