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  • N&PD Moderators: Skorpio | someguyontheinternet

Ketamine salts solubility

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We need add to be more active. Do you guys need another mod? Pullleèeeaàse.

Did you know clonazepam increases growth hormone? Haha.
 
Forums like this are never that busy but I think that's fine. It emphasizes quality over quantity.
 
Thanks! That honestly means so much coming from you.

And why isn't D-Deprenyl scheduled ;)

Seems like a promising new treatment for resistant depression/attention disorders.
 
I wouldn't expect it to be much different from l-deprenyl--that's a tiny, tiny amount of d-meth and d-amp that it catabolizes to.

ebola
 
Also like d-amphetamine, d-deprenyl maintained drug-seeking behavior in a dose-dependent manner, with rates and patterns of responding similar those maintained by the most effective dose of d-amphetamine (0.56 mg/kg). In contrast, mean response rates maintained by l-deprenyl were much lower than those maintained by either d-amphetamine or d-deprenyl, showing only a hint of an inverted U-shaped dose-effect function, with a peak in mean response rates at 1.0 mg/kg and a decline in response rates at the high 10 mg/kg dose.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360227/
 
Typical doses of l-deprenyl for humans range from ~.05 mg/kg to .15 mg/kg (administered sublingually or trans-dermally). This study involved intravenous administration of d-deprenyl at doses ranging from 1 to 3 mg/kg. So yes, I would expect the metabolites to prove behaviorally relevant at 6.67 to 60 times the typical dosages. :P

ebola
 
it didn't matter how much l-deprenyl they administered, though... it never produced reinforcing behavior. ho chi minh's question "And why isn't D-Deprenyl scheduled?" is a good question... d-deprenyl looks like it could potentially be a drug of abuse. at 6x-60x doses, sure, but amphetaine heads take 6x-60x dosages too.
 
I think that another couple parts of the story are that d-deprenyl is not a common prescription drug, and clandestine syntheses are nonexistent, so scheduling is unnecessary. The DEA typically avoids scheduling compounds when the additional publicity it would give them outweighs the amount of recreational use the regulations would be expected to prevent. Also, deprenyl's typical synthesis involves methamphetamine as a precursor (heh...doing a bit to explain why d-deprenyl was not pursued as a prescription medication).

ebola
 
Minh, I don't believe ebola was saying that it wasn't potentially recreational. He was responding to this:

thenightwatch said:
ho chi minh's question "And why isn't D-Deprenyl scheduled?" is a good question... d-deprenyl looks like it could potentially be a drug of abuse. at 6x-60x doses, sure, but amphetaine heads take 6x-60x dosages too.
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Simply explaining why it likely isn't scheduled like other drugs with similar abuse potential.
 
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