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Ketamine salts solubility

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Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299 (2005; a little old I know, but worth mentioning)
Free full text: http://www.pnas.org/content/102/48/17489.full.pdf

SNAP 37889
snap37889.gif
, SNAP 398299
snap398299.gif

Administration of these two compounds (per the oral route) results in acute antidepressant/anxiolytic effects in mice/guinea pigs. Anxiolytic activity for SNAP 37889 begins at 0.3mg/kg is strong at 5mg/kg up to 30mg/kg, comparable to 5mg/kg of the benzodiazepine chlordiazepoxide at the highest dose level. Effective dose in humans if bioavailability via the oral route is good would then scale at a guesstimate to be 1-25mg. References for the synthesis of these molecules is given.
 
Exploration of Novel 3-Substituted Azetidine Derivatives As Triple Reuptake Inhibitors
http://pubs.acs.org/doi/abs/10.1021/jm3008294

jm-2012-008294_0004.gif

Novel azetidines based on the 3-aryl-3-oxypropylamine scaffold were designed, synthesized, and evaluated as TRIs. Reduction of 1 followed by Swern oxidation and then Grignard reaction gave 3. The alkylation of 3 provided the corresponding azetidine derivatives 6, of which the two most promising, 6bd and 6be, were selected from 86 prepared analogues based on their biological profiles. Compound 6be showed activity in vivo in FST at 10 mg/kg IV or 20–40 mg/kg PO.
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Can anyone get this paper:

The treatment outcome of psychotic disorders by traditional healers in central Sudan.
Sorketti EA, Zainal NZ, Habil MH.

Abstract
BACKGROUND:
Alternative and traditional healing methods are common and popular in Sudan, particularly for treating people with mental disorders, but little information is available about the outcome of theses traditional healing approaches.

OBJECTIVES:
To study the outcome of treating patients with psychotic disorders by traditional healers, and to understand the type of services, interventions procedures and treatments methods used by traditional healers to manage patients with psychotic disorders.

METHOD:
A prospective follow-up quantitative study of a cohort of inpatients with psychotic disorders was carried out from admission until discharge. Subjects were people with psychotic disorders undergoing treatment in traditional healer centres in central Sudan. The Mini International Neuropsychiatric Interview (MINI) was used to diagnose the psychotic disorders and the Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychotic symptoms on admission and discharge from the traditional healer centre.

RESULTS:
We interviewed 129 inpatients with psychotic disorders on admission and discharge from the traditional healers centres. There was a significant reduction in the PANSS score (p = .0001) after a mean period of stay of 4.5 months. The mean for the overall PANSS score was 118.36 on admission and 69.36 on discharge.

CONCLUSION:
Although traditional-healing approaches produce a significant improvement in the signs and symptoms of psychotic disorders measured on the PANSS, they need to be further investigated, assessed and studied.

Pubmed
Article link
 
skillet said:
Can anyone get this paper:

The treatment outcome of psychotic disorders by traditional healers in central Sudan.
Sorketti EA, Zainal NZ, Habil MH.

Abstract
BACKGROUND:
Alternative and traditional healing methods are common and popular in Sudan, particularly for treating people with mental disorders, but little information is available about the outcome of theses traditional healing approaches.

OBJECTIVES:
To study the outcome of treating patients with psychotic disorders by traditional healers, and to understand the type of services, interventions procedures and treatments methods used by traditional healers to manage patients with psychotic disorders.

METHOD:
A prospective follow-up quantitative study of a cohort of inpatients with psychotic disorders was carried out from admission until discharge. Subjects were people with psychotic disorders undergoing treatment in traditional healer centres in central Sudan. The Mini International Neuropsychiatric Interview (MINI) was used to diagnose the psychotic disorders and the Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychotic symptoms on admission and discharge from the traditional healer centre.

RESULTS:
We interviewed 129 inpatients with psychotic disorders on admission and discharge from the traditional healers centres. There was a significant reduction in the PANSS score (p = .0001) after a mean period of stay of 4.5 months. The mean for the overall PANSS score was 118.36 on admission and 69.36 on discharge.

CONCLUSION:
Although traditional-healing approaches produce a significant improvement in the signs and symptoms of psychotic disorders measured on the PANSS, they need to be further investigated, assessed and studied.

Pubmed
Article link
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Try this
 
Ronald S. Duman, George K. Aghajanian
Synaptic Dysfunction in Depression
Science 5 October 2012: Vol. 338 no. 6103 pp. 68-72
DOI: 10.1126/science.1222939

Basic and clinical studies demonstrate that depression is associated with reduced size of brain regions that regulate mood and cognition, including the prefrontal cortex and the hippocampus, and decreased neuronal synapses in these areas. Antidepressants can block or reverse these neuronal deficits, although typical antidepressants have limited efficacy and delayed response times of weeks to months. A notable recent discovery shows that ketamine, a N-methyl-d-aspartate receptor antagonist, produces rapid (within hours) antidepressant responses in patients who are resistant to typical antidepressants. Basic studies show that ketamine rapidly induces synaptogenesis and reverses the synaptic deficits caused by chronic stress. These findings highlight the central importance of homeostatic control of mood circuit connections and form the basis of a synaptogenic hypothesis of depression and treatment response.
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thenightwatch said:
i had this idea once too =p



epsilon alpha, did you figure out what your lab supervisor's BL handle is?
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I think he just lurks, he does toxicology and behavioral pharmacology for a certain class of "legal high". It wouldn't surprise me if he comes here looking to identify the next potential mephedrone.
 
It will be hard to get a social going when it gets 143 views worldwide in 36 hours though lol. It's hard to keep a social going when there might be 2 users viewing the sub-forum at once.
 
I want this as a lounge substitute.

The lounge is like civilization.

It's a good idea and I'd love to see it some time work as intended... We certainly haven't had anything like it before.

I think Ghandi said that. No this is just to talk and relax and post science cat. Because he's nerdy adorable. And maybe I'll learn something. I never post here because my knowledge of neuro-chemistry and science is novice, but I know a fair bit and am only interested in expanding that knowledge.

So, yeah. But thank Science Cat. He was my muse.

And for stuff like this:

A physicist, biologist and a chemist were going to the ocean for the first time.

The physicist saw the ocean and was fascinated by the waves. He said he wanted to do some research on the fluid dynamics of the waves and walked into the ocean. Obviously he was drowned and never returned.

The biologist said he wanted to do research on the flora and fauna inside the ocean and walked inside the ocean. He too, never returned.

The chemist waited for a long time and afterwards, wrote the observation, "The physicist and the biologist are soluble in ocean water".
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I lol'd pretty hard, I'll have to use that one later this week!

But, what got you guys into pharmacology?
 
Epsilon Alpha said:
I lol'd pretty hard, I'll have to use that one later this week!

But, what got you guys into pharmacology?
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Becoming a CPP and seeing how much drugs could actually help out an individual (not just fuck them up). I know I'm pretty useless around these parts at the moment, but I've only got gen chem I and half of gen chem II down as far as formal science education (got an incomplete due to health complications). Definitely wanting to go into medicinal chemistry as it interests me so much. Was just going to go into a pharm program, but decided it would probably get boring just counting pills and telling old ladies to avoid ant-acids with certain antibiotics and to steer clear of grapefruit with certain meds. Not to mention it would be difficult standing 8-12 hours a day with my health problems anyway.

*Now commences 12 day waiting period for response* :P
 
Epsilon Alpha said:
I lol'd pretty hard, I'll have to use that one later this week!

But, what got you guys into pharmacology?
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Psychedelics, and the profound change in mental state they can create. Mind you, this was before I had done any drugs, save weed maybe. They're still the most fascinating class of drugs, although recently I've become really interested in pain, simply because it's a complex integration of both sensory and affective components to give a perception that is totally subjective. On this topic, I still haven't really told anyone that's why I've gone into pharmacology. I figure I'll get a little more confidence to tell the truth, partially because several different graduate students I've talked to are really interested/have experimented with psychedelics. Seems like a scientist thing.

I went to Horizons the other weekend, and I was somewhat surprised by the sheer number of professors talking about their personal experiences with psychedelics during their talks. I guess I shouldn't be, but I've always thought that they would be more reserved when talking to 100 people or so. It was an awesome introduction though. Met up with one bluelighter, although we really didn't talk much...
 
Same here, but I'm a novice. That and being given drugs at a young and an inquisitive mind and a sense of wrath for when I went back to the fink who hooked me on high dose effexor 15 years old armed with a sharp tongue and a sense of justice to return to, without having to resort to foul language.

Fool me once? Last time motherfucker.


Anyway, if I were to have a culture of psilocybe mycelium and jumped in, would we get 4-phosp. thou? I forget they do hydroxylize? 4 ho Scott?
 
the idea that mushrooms will add a 4-hydroxy/phosphoryloxy to more than just DMT is currently just a theory as far as i know. highly doubtful that we'd get 4-PO-Thou. and i wouldn't be willing to be the guinea pig if we did. =p
 
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