Ketamine salts solubility

[sekio]

Baclofen has good bioavailibility, but generally BA is determined by measuring the amount of drug absorbed into the bloodstream and not i.e. the brain or CSF.
Wiki sez: Intrathecal pumps offer much lower doses of baclofen because they are designed to deliver the medication directly to the spinal fluid rather than going through the digestive and blood system first. They are often preferred in spasticity patients such as those with spastic diplegia, as very little of the oral dose actually reaches the spinal fluid.

Likewise, intrathecal morphine is actually more effective than even IV morphine, again because only a portion of an administred dose crosses BBB and makes it to the brain/spinal cord.

There is also the benefit of not requiring to repeatedly dose oral medications, an intrathecal pump can provide constant levels of drug even when you're asleep.

 

[thegreenhand]

Ah thank you for the explanation! A "slow drip" is certainly always better i would imagine, hence the popular use of fentanyl patches in modern medicine

 

[Rectify]

DOO DOO BROWN!
1-(2,6-dibromo-4-methoxyphenyl)-2-aminopropane

 

[Gaffy]

DISCLOSURE

4-CHLORO-EPHYLONE

Or 4-Chloro-7-Ethyl-8-PhenYlOctaHydroIndolIziNe
Very good stats

I will do you the honor of naming this one, Rectify, or should I say Dresden

4-Fluoro-7-Ethyl-8PhenylOctahydroIndolizine

Link: https://i.ibb.co/jR8sBfN/Screenshot-20201113-162903-2.png

4F STP STATS

 

[Rectify]

PLUDOS PLAY DOH
1,6-dibenzoylpyrrolizidine

OORT cloud ROOT down TORO rojo (OcRdTr)
1-(indole-3-yl)-2,6-dioxopyrrolizidine

HYDROGENATED BETEL NUT GEUSE ARECOLINE CAROLINA, NORTH & SOUTH (HBNGACNAS)
1-methyl-3-carbomethoxypiperidine

GENIUS SEDATING ANTIDEPRESSANT (NU-SKOOL) based on Valium, largely.
7,8-methylenedioxy-1-(3-dimethylaminopropyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-one

 

[Rectify]

FREDERICK SHAKESPEARE'S SISTER NIETSZCHE FRANZ KAFKAESQUE
1-methyl-3-oxo-1-diethylamino-4-carbomethoxy-4-phenyl-4-(3,4-methylenedioxyphenyl)butane

 

[Gaffy]

CARDIOTOXIN

 

[Rectify]

I'm Chasing

AMBER
1-(4-methoxyphenyl)-1-methoxy-2-ethylaminopropane

 

[Ketamania]

a-PCYP
2-cyclohexyl-1-phenyl-2-(pyrrolidin-1-yl)ethan-1-one

A cathinone (bath salt) that I have experimented upon. Fantastic high, seriously high heart rate. Way more euphoric than any stimulant i have ever tried, better than meth. However, it is EXTREMELY addicting and ended up having to flush this one. I can see how one can have a heart attack if they take took much or are susceptible to cardiac problems. I'd rate the high 10/10 but the comedown a -100/10. Overall, don't try it. It won't make you into a 'zombie' or anything, giant myth.

 

[Rectify]

I want some.

 

[Rectify]

Your Pharmies Are Basic Compared To Mine. A Search For The Higher Intelligence. The Most Benevolent King. Communicating Through Your Dreams. Understanding Makes My Truth Crystal Clear.

PLOYD FENNINGTON
1-(3,4-methylenedioxyphenyl)-1-oxo-2-(1-pyrrolidinyl)-2-cyclopentylethane

 

[Rectify]

MARK PLATT
7-chloro-1,3-dihydro-1-ethyl-5-thiophenyl-1,4-benzodiazepine-2-one

Of Course It Works.

 

[Rectify]

THE ENCHANTING WIZARD OF GRAND MASTER FLASHDOM
2-ethylamino-3-(3,4-methylenedioxyphenyl)-3-(o-tolyloxy)propane

 

[clubcard]

image-2020-11-16-013403 hosted at ImgBB

Image image-2020-11-16-013403 hosted in ImgBB

ibb.co

And just for a change, here's one that is known to work. The methylene bridge places the N: in the same relative position to the aryl as the aryl:methylamine of nortilidine. Of course, it's fun, fun, fun to make but it IS very rigid and so it's affinity is pretty decent. I cam across it in a 1960s German paper on tilidine and related compounds. Always remember that it isn't the N but the N: position & orientation is what matters. That is why unusual compounds like dezocine are primary amines and why they are mixed agonist/antagonist.

MANY years ago researchers produced quaternary salts of common opiates like morphine so, in practice there was a chiral centre and it turned out that 1 isomers was an agonist, the other was either an antagonist (phenol or bioisostere thereof) allowing.

I find it interesting because it showed that some keen medicinal chemists asked a simple 'what if?' and proved it to be true.

Secondary amines usually have a conformation that places the N-alkyl opposing the N: and so they turn out to be agonists. Above you will note an example of a secondary amine. I suspect it is a total bitch to make and some poor post-grad student ended up as an 'et al' even if it took them a year.

You will note that like tramadol (also a DRI/NRI without the ester) is closely related. I think I have pointed out that it is possible to produce a highly EUPHORIC opioid (due to DRI action) based on some quite average DRI/NRI lligands.

Since lat post I've had the chance to try the N-methyl homologue of isopilidine. It lasts for a good 6 hours. It is highly euphoric so all I can say is that people do NOT try to find a regular dealer. I've seen chemist/users who were obtaining bottles of the stuff and converting it to something very similar,just x10 more potent.

Of course, it's the DRI/NRI action that makes it different BUT I do not know IF it has NMDA activity, someone could make billions. Now, think about that - if dealers make billions, WHO LOSES.

image-2020-11-16-154921 hosted at ImgBB

Image image-2020-11-16-154921 hosted in ImgBB

ibb.co

Nowm, I admit that I have suggested MANY terminal aryls (based on Lednicer's work) but while not being the compute, Lednicer mentioned this as a more practical, longer-acting analogue. The KEY is that usually the aromatic is hydroxylated but with many 5-membered heterocycles, this isn't possible. The 2-thiophene analogue was known and tested and turned out to be x267 (rather than x204 for the parent.

Of course, the key is NOT to rely on aromatic hydroxylation because it is not relaible between to patients. Yeah, we could make it VERY hard to metabolise, but something x504 REALLY does not need modification.

If you must play, swap the phenolic -OH of morphine and derivatives to a carboxmide which has a MUCH longer duration.

We may also do well to look at the methadone analogues, Several were noted as being 'moreish' i.e. people took for fun, tot for main.

Well, whatever, expect hydromorphone analoguse very soon. JUST ABOUT kitchen chemistry and fuck, it it's x10 H, EVERYONE will be at it.

 

[clubcard]

a-PCYP
2-cyclohexyl-1-phenyl-2-(pyrrolidin-1-yl)ethan-1-one

A cathinone (bath salt) that I have experimented upon. Fantastic high, seriously high heart rate. Way more euphoric than any stimulant i have ever tried, better than meth. However, it is EXTREMELY addicting and ended up having to flush this one. I can see how one can have a heart attack if they take took much or are susceptible to cardiac problems. I'd rate the high 10/10 but the comedown a -100/10. Overall, don't try it. It won't make you into a 'zombie' or anything, giant myth.

Made, stimulant. The 1,2-diary was more potent.

 

[Rectify]

clubcard,

Wow, you are really on top of this.

ANGEL
N-methyl-3-(oxa-piperonyl)norbornan-2-amine

 

[Rectify]

I'M WITH STOOPID
1-aza-3-carbomethoxy-4-(oxapiperonyl)norbornane

NITRODAPSONE
di(4-nitrophenyl)sulfone

broad spectrum antimicrobial for acne, Leprosy (Lou Hansen's disease), syphilis, pinta, yaws, Lyme's disease etc.

MIAGRA
1-methylpiperazin-4-yl 3,4-methylenedioxyphenyl sulfone

possible erection enhancer

CON Q PISS ANT
1-methylpiperazin-4-yl phenyl sulfone
possible aphrodisiac

"Be Like The Ant."--The Bible.

 

[Rectify]

REESE STANFORD WITHERSPOON
(2S,5R,6R)-2-carbomethoxy-3,3-dimethyl-7-oxo-6-(2-phenyl-1-methylethylamino)-4-propylsulfanyl-1-azabicyclo [3.2.0]heptane

Many Things Are Possible When You Don't GAF Who Gets The Recognition

TAMISHA WHAT U TALKING ABOUT ARNOLD BRUCE WILLIS DEMI MOORE HOWARD STERN HUGHES LEONARDO DICAPRIO KIMBERLY TONY DANZA
3-carbomethoxy-1-cyclopropyl-6-chloro-4-oxo-7-(piperazin-1-yl)quinoline

antibiotic

WHOOPI ARNOLD SISTER ACT KINDERGARTEN COP GOLDBERG SCHARZENEGGER
1,3,7-tricyclopropylxanthine

terra incognita

Cogito, ergo zoom.

FLORENCE NIGHTINGALE KERRY ZDRAVKOVICH SEARLE SHEILA NAOMI CAMPBELL WILLIAMSII CATENA THE 3RD
2-carbomethoxy-6-(2-(4-methoxyphenyl)-1-(methyl)ethylamino)-3-{2-[(iminoethyl)amino]ethyl}thio-7-oxo-1-azabicyclo[3.2.0]hept-2-ene

I told you so.

 

[Rectify]

PIPERAZINE
anthelmintic

WHOOP! there it is.
2-carbomethoxy-3-propylthio-6-(dichloroacetamido)-4,7-dioxo-1-azabicyclo[3.2.0]hept-2-ene

I AM THE RESURRECTION.

CHANDRAN AMOXICILLIN IMIPENEM HARVARD MIT SESHARGIRI
(6S)-2-carbomethoxy-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-4,7-dioxo-3-propylthio-1-azabicyclo[3.2.0]heptane

OM NAMA SHIVAYA

EMINEM
para-benzoquinone

Pd(II)Cl2
WENDY CRUMPLER FAEMS

CH3OH deadly
WOOD ALCOHOL

ETHYL ALCOHOL
CH3CH2OH

PROPYL ALCOHOL
CH3CH2CH2OH

Ethyl Tricks Methyl

KENDRA MICHELLE OBAMA JASON JONES JENN ALEXANDER WARD

7-bromo-6-piperazinyl-2,3-methylenedioxy-5-hydroxy-1,4-naphthalenedione

Have A Disease?
There's A Cure For That!

CALAMITY JANE
1-(2,4,5-trimethoxyphenyl)-2-aminopropane

frrom Acorus calamus oil

APPLE TREE AMPHETAMINE
1-(2,4,6-trimethoxyphenyl)-2-aminopropane

Time Was Ended Recently During The Age Of Aquarius, So Let The Sunshine In!

 

[Gaffy]

I'M WITH STOOPID
1-aza-3-carbomethoxy-4-(oxapiperonyl)norbornane

NITRODAPSONE
di(4-nitrophenyl)sulfone

broad spectrum antimicrobial for acne, Leprosy (Lou Hansen's disease), syphilis, pinta, yaws, Lyme's disease etc.

MIAGRA
1-methylpiperazin-4-yl 3,4-methylenedioxyphenyl sulfone

possible erection enhancer

CON Q PISS ANT
1-methylpiperazin-4-yl phenyl sulfone
possible aphrodisiac

"Be Like The Ant."--The Bible.

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