Ketamine salts solubility

[Bagseed]

Fiedels Craft acylation of 2-carboxy piperidine in benzene

wouldn't the acyl chloride in the precursor also react with the nitrogen in the piperidine ring to form amide?

 

[clubcard]

wouldn't the acyl chloride in the precursor also react with the nitrogen in the piperidine ring to form amide?

For a start - then I suppose we can all guess where the HCl shows up? Indeed, why would the god of chemistry see fit to add just 1 meta acyl group? I suppose Levophacetoperane is the closest so maybe it's worth dredging through all that to discover that it doesn't offer any help at all.

 

[Rectify]

If 2-carboxypiperidine is added dropwise as the limiting reagent in a large excess of benzene, it won't be a problem.

MEREDITH
1-(4-methylphenyl)-1-(2-piperidinyl)methanone

 

[Rectify]

Better yet, use hypophophorous acid and avoid finicky halogens entirely!!!

 

[clubcard]

If 2-carboxypiperidine is added dropwise as the limiting reagent in a large excess of benzene, it won't be a problem.

MEREDITH
1-(4-methylphenyl)-1-(2-piperidinyl)methanone

Nope. Ann acyl chloride will bind to the basic N first and who is to say where else and how many other times will be an issue.

But by all means perform the reaction and supply lab notes.

 

[Rectify]

Thesis: Benzene plus hypophosphorus acid and 2-carboxypiperidine.

 

[Rectify]

MELISSA
1-(3-bromophenyl)-2-aminopropane

'BEE'

 

[Rectify]

MICHAEL
1-(5-methylthio-indole-3-yl)-2-aminopropane

FOD
1-methylamino-1-(2-fluorophenyl)cyclohexane

JUICE
4-hydroxybutanal

 

[thegreenhand]

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin - Neuropsychopharmacology

There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin, for disorders characterized by distortions of the self-experience, like depression. Accumulating preclinical evidence emphasizes the role of the glutamate system in the acute action of the drug on...

www.nature.com

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

Abstract:
There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin, for disorders characterized by distortions of the self-experience, like depression. Accumulating preclinical evidence emphasizes the role of the glutamate system in the acute action of the drug on brain and behavior; however this has never been tested in humans. Following a double-blind, placebo-controlled, parallel group design, we utilized an ultra-high field multimodal brain imaging approach and demonstrated that psilocybin (0.17 mg/kg) induced region-dependent alterations in glutamate, which predicted distortions in the subjective experience of one’s self (ego dissolution). Whereas higher levels of medial prefrontal cortical glutamate were associated with negatively experienced ego dissolution, lower levels in hippocampal glutamate were associated with positively experienced ego dissolution. Such findings provide further insights into the underlying neurobiological mechanisms of the psychedelic, as well as the baseline, state. Importantly, they may also provide a neurochemical basis for therapeutic effects as witnessed in ongoing clinical trials.

 

[Skorpio]

Here's another one on glutamate and consciousness, this one is on sheep k holing. Apparently very high dose (24 mg/kg) is ketamine produces complete silence in sheep corticies.

This is probably the first study of recreational ketamine using brain imaging, and while crude is fairly interesting

Characteristic patterns of EEG oscillations in sheep (Ovis aries) induced by ketamine may explain the psychotropic effects seen in humans

• A. U. Nicol &
• A. J. Morton

Scientific Reports volume 10, Article number: 9440

Abstract
Ketamine is a valuable anaesthetic and analgesic that in recent years has gained notoriety as a recreational drug. Recently, ketamine has also been proposed as a novel treatment for depression and post-traumatic stress disorder. Beyond its anaesthetic actions, however, the effects of ketamine on brain activity have rarely been probed. Here we examined the cortical electroencephalography (EEG) response to ketamine of 12 sheep. Following ketamine administration, EEG changes were immediate and widespread, affecting the full extent of the EEG frequency spectrum measured (0–125 Hz). After recovery from sedation during which low frequency activity dominated, the EEG was characterised by short periods (2–3 s) of alternating low (<14 Hz) and high (>35 Hz) frequency oscillation. This alternating EEG rhythm phase is likely to underlie the dissociative actions of ketamine, since it is during this phase that ketamine users report hallucinations. At the highest intravenous dose used (24 mg/kg), in 5/6 sheep we observed a novel effect of ketamine, namely the complete cessation of cortical EEG activity. This persisted for up to several minutes, after which cortical activity resumed. This phenomenon is likely to explain the ‘k-hole’, a state of oblivion likened to a near death experience that is keenly sought by ketamine abusers.

Characteristic patterns of EEG oscillations in sheep (Ovis aries) induced by ketamine may explain the psychotropic effects seen in humans - Scientific Reports

Ketamine is a valuable anaesthetic and analgesic that in recent years has gained notoriety as a recreational drug. Recently, ketamine has also been proposed as a novel treatment for depression and post-traumatic stress disorder. Beyond its anaesthetic actions, however, the effects of ketamine on...

www.nature.com

 

[Rectify]

VENMO
piperidin-4-yl 2,6-dimethylpyridin-4-yl ether

AWESOME_BLOSSOM
piperidin-4-yl 3,5-dimethoxypyridine-4-yl ether

 

[thegreenhand]

I’d like to see more research on anesthetics in general. Their mechanisms are still not fully understood, if I remember correctly.

They seem to be a good jumping off point into exploring the nature of consciousness given their ability to put it on pause

 

[Rectify]

 

[Rectify]

AARON
piperidin-4-yl 2,4,6-trichlorophenyl ether

MOSES
piperidin-4-yl 2,4,6-tribromophenyl ether

TASTY
racemic di reverse ester heroin

 

[Rectify]

CLAIRE
1-(4-chloro-2,6-dimethoxyphenyl)-2-aminopropane

SCUTUM
1-(5-chloroindole-3-yl)-2-aminopropane

Gone Get Down With Me.
Gone Get Down With Me.
Gone Make You Freak!

 

[Rectify]

NED
N-EthylDopamine
N-ethyl-1-(3,4-dihydroxyphenyl)-2-aminoethane

 

[Rectify]

WOODY 'DALTON' HARRELSON
Bk-1-oxo-N,N-diallyltryptamine

AMBER_GRIS
1-(2,4,6-trideuterophenyl)-2-aminopropane

If you glow in the dark, then you are radioactive!

 

[Rectify]

10-METHYL-ANAFRANIL
N,N-dimethyl-10-methyl-10,11-dihydro-3-chlorodibenz[b,f]azepine-5-propanamine

-is a cross between Anafranil and Trileptal

BROMO-THORAZINE
-2-bromo instead of 2-chloro Thorazine

RESURGENCE
8-chloro-11-(2-methylaminopropyl)-5H-dibenz[b,e][1,4]diazepine

 

[Rectify]

AMPHETAMINE
1-phenyl-2-aminopropane

METHAMPHETAMINE
1-phenyl-2-methylaminopropane

ETHAMPHETAMINE
1-phenyl-2-ethylaminopropane
*highly recommended*

MDA (''The Love Drug')
1-(3,4-methylenedioxyphenyl)2-aminopropane

MDMA ('ECSTASY'; ADAM; X)
1-(3,4-methylenedioxyphenyl)-2-methylaminopropane

MDE ('EVE'; a smacky roll)i
1-(3,4-methylenedioxyphenyl)-2-ethylaminopropane

These 6 Drugs Will Keep You Happily Busy For A *Long* Time. The first 3 should be the S (+) isomer only; the last three are generally best as racemates. The hydrochloride salt is best. The sulfate salt, for example, is hygroscopic.

 

[Rectify]

PER-DEUTEROATED-AMPHETAMINE
1-(6,2,3,4,5-pentadeuterophenyl)-2-amino-1,1,2,3,3,3-hexadeuteropropane
'Heavy Amphetamine.'

i

ELEMICIN
3,4,5-trimethoxy-1-allylbenzene

MESCALINE
1-(3,4,5-trimethoxyphenyl)-2-aminoethane

TMA-1
1-(3,4,5-trimethoxyphenyl)-2-aminopropane

LOPHOPHINE
1-(3,4-methylenedioxy-5-methoxyphenyl)-2-aminoethane

MMDA
1-(3,4-methylenedioxy-5-methoxyphenyl)-2-aminopropane

SHEVA
1-(3,4,5-trichlorophenyl)-2-aminopropane
-mild stimulant with color enhancement