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Ketamine salts solubility

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LIMINAL_SHADOW_SPACE
N,N-di-allyl-1-indole-3-yl-1-aminocyclohexane

Because It's About That Time In The Morning Here. Twilight. My Least Favorite Time Of Day. When Stress Hormones Peak And Alarm Clocks Start To Systematically And Ruthlessly Terrorize The Slumbering Ones. OTOH, There's Also Sometimes Morning Wood! The 5th Element! LMAO.
 
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SPACE_X
N-allyl-(2,6-dimethoxy-4-pentylphenyl)-1-methoxy-2-aminopropane

I Am Your Sunshine, Your Only Sunshine!
 
SPACE_X is fire!

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NEWT_SWANN_GINGRICH
N-allyl-1-(3,4-methylenedioxy-5-methoxyphenyl)-1-methoxy-2-aminopropane
 
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NEO_HARE_KRISHNA aka Steve Carell Of "The Office."
N-allyl-1-(3,4,5-trimethoxyphenyl)-1-methoxy-2-aminopropane

The 3,4,5's are, well, God like!

It's NOT L.O.V.E!
 
ANNIHILATING RHYTHM! The AMEN Break Is A 7.2 Second Loop Which is Also The Most Addictive Rhythm!

 
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I_DO_IT_RIGHT_CUZ_I_CAINT_DO_IT_WRONG_THATS_WHY_THE_WHOLE_WORLD_IS_SINGING_THIS_SONG!
 
The Red Hot Chili Peppers Have Known I Am The ONE Since Their 2001 Release, Californication!
 
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WESLEY_CHRIS_CORNELIUS_FARLEY
N-allyl-1-(2,5-dimethoxy-4-bromophenyl)-1-methoxy-2-aminopropane

Chris Is One Of The Few Bisexual Names I Can Think Of. He's A Great Guy, Too.
 
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IAN,ANDREW,&MADONNA
N-allyl-1-(4-methoxyphenyl)-1-methoxy-2-aminopropane

We Were Quite The Trifecta To Be Reckoned With For A Long Time.
 
Whenever A Soulful AMEN Break Is Played Loudly All Night Long, Great & Glorious Destruction Takes Place!
 
I cannot remember if I already posted these links, but they carry out Lipinski's rule of 5 automatically. It's the first step towards ensuring your compound will be active.

Calculation of molecular properties

Molecular properties calculated by Molinspiration Toolkit (logP, PSA, drug-likeness ...)
www.molinspiration.com

Lipinski Rule of Five

Binding Affinity Prediction of Protein-Ligand complex containing Zinc [ BAPPL-Z ] server computes the binding free energy of a zinc containing metalloprotein-ligand complex using an all atom energy based empirical scoring function
www.scfbio-iitd.res.in

molinspiration also deals with tautomers, rotamers and atropisomers but NOT macromolecular overcrowding.

I just discovered that it was my friend, Dan Lednicer who made & resolved helicine (which can be in a left-hand or right-hand spiral) for his pHd. If you don't know Dan by name, you may recognize his famous quote which was the entirety of the dedication of his book on hormones:

'To libido. Without which the work described in this volume would have been neither possible or necessary'.
 
Is The Drug SHIVA [3,4,5-trichloroamphetamine.hcl] Really All That Special?

No, Not Really. But It Is Very Gentle, Functional, Nice, And With Good Color Enhancement. Plus, With It's 3 Aromatic Energy Deactivating Chlorines Is Even LOWER Energy [more stable] Than Jesus Of Nazareth's Spirit Molecule, 3,4-dichloromethamphetamine.hcl which is UP UP And AWAY [phonetically, YAHWEH backwards] The Drug THEY Really Don't Want You To Take, But Which I Already Have, And Is At This Late Date The True Christian's ONLY Hope! Unless Of Course, And Even Then Not Really, You Can Get Ahold Of Its Highest (n = 5) Order N,beta-methoxy, N-allylic-3,4-dichloroamphetamine.hcl XTAL, Jason Hodor Llyod Jones, Which I Took Last Week And Finally, Somewhat Sadly To Me, Seems To Have Finally Laid His Spirit To Rest In The Left Side Of My Body By Say, 95%. Great Genital And Anal Masturbation Were Had With An Oiled, Slender, Spent Glowstick And Now Brand Jasmine Absolute Essential Oil On My 4.5 Inch When Fully Erect Cock, With Some Good Quality Nag Champa Oil In My Ass. But That's NSFW!
 
It's the 2,5 substitution being planer that increases affinity the most e.g. bromo-dragonfly. Those 2 furan rings are planer while the -CH3 of the methoxy is not planer. Evidently one can alter action via differing space-filling and electronic character, but I think Nichols has mapped the receptor.
 
It's true that synthetic complexity does make a big difference in choosing classes to explore.

I'm keen to see if anyone spots that U-47700 can be modified, at no increased synthetic cost, to be x4 more potent or that viminol analogues are quite good targets since producing chiral secondary amine is VERY cheap so right away you are up to x15 M. Then, their is a route that while I wouldn't be too keen on, does reduce synthesis to 3 steps. It's just that it uses a rather nasty reagent.

It's datamining that I spend the most time on. Averaging 200 Reaxys searches a day for years does mean I've seen a lot of pathways and sometimes you find a telescoped synthetic pathway for a common medicine that can equally be applied elsewhere. That is why isophenidine can be made in 1 step @ RT using safe reagents - I found the trick in a sertraline patent.
 
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