Dissociatives Ketamine cross tolerance to other non dissios?

[Bitchniggaz]

Ive noticed the last years that my alcohol tolerance has gotten crazy.
The thing is that i rarely even drink.

Just a few years ago i would get quite drunk from 3-4beers.
With a decent hangover aswell.
But in the rate that my ket tolerance went up so did the amount of alcohol i could consume.


Anyone else noticed anything similar?
A few days ago i drank nonstop for over 12h (+10 beers and some hard spirits)
But i never really got drunk from it, and the hangover wasnt too bad either.

 

[jhjhsdi]

I wasn't aware that ket tolerance could affect alcohol tolerance, but I'm no doctor.

Alcohol lowers my tolerance to ket while im drunk, eg, a Xmg line wouldn't do fuck all to me, but if i drink say 8 cans then do the same size line it will do more. Doesn't seem to work the opposite way though

 

[Hexagon Sun]

disos low/reset the tolerance to other drugs, so normally it works more the other way. For example, you have tolerance to LSD, but a disso resets it, so youcan get again effects from a low dose.

Maybe alcohol is different? Honestly I dont know

 

[jhjhsdi]

disos low/reset the tolerance to other drugs, so normally it works more the other way. For example, you have tolerance to LSD, but a disso resets it, so youcan get again effects from a low dose.

Maybe alcohol is different? Honestly I dont know

I always heard being on a small dose of 3-meo-pcp can reset your tolerance to ket.
As someone with a stupid tolerance to k, I've always wanted to test this theory out, but sadly never had chance to try 3-meo-pcp

 

[Hexagon Sun]

I always heard being on a small dose of 3-meo-pcp can reset your tolerance to ket.
As someone with a stupid tolerance to k, I've always wanted to test this theory out, but sadly never had chance to try 3-meo-pcp

I would say nopes. 3-meo more like should add tolerance to K rather than clear it. Dissos should reset tolerance to everything but dissos...

Could be that there´s some special quirkynes that does somehow reset some aspects of K but it doesnt sound very logical

 

[Img_9999]

Alcohol Is also an NMDA antagonist, so theres that

 

[jhjhsdi]

I would say nopes. 3-meo more like should add tolerance to K rather than clear it. Dissos should reset tolerance to everything but dissos...

Could be that there´s some special quirkynes that does somehow reset some aspects of K but it doesnt sound very logical

I never said it sounded logical, still intrigued

 

[Hexagon Sun]

Yeah, speculatively doesnt sound logical, but if in practice it works, it works. And that should point us to a refinement in the theory (what´s the mechanics why does it works?)

 

[Img_9999]

I always heard being on a small dose of 3-meo-pcp can reset your tolerance to ket.
As someone with a stupid tolerance to k, I've always wanted to test this theory out, but sadly never had chance to try 3-meo-pcp

I don´t think it resets the tolerance to K, but what really does is potentiate it. Everytime I've added a small dose of 3-MeO-PCP to a disso the effects are significantly amplified. There definitely is a synergistic effect. But I think it's not tolerance reversal, but you are effectively taking more NMDA antagonists, hence a stronger effect.

 

[Xorkoth]

I would say nopes. 3-meo more like should add tolerance to K rather than clear it. Dissos should reset tolerance to everything but dissos...

Could be that there´s some special quirkynes that does somehow reset some aspects of K but it doesnt sound very logical

I think he's saying that already being on 3-MeO-PCP makes ketamine stronger, which is quite logical, and it certainly does, since it's mixing two dissociatives and they potentiate each other. But as far as tolerance, combining them will develop more tolerance over time than doing just one or the other.

 

[negrogesic]

There is some cross tolerance between alcohol and ketamine but not sure how significant. Ethanol analgesia is likely strongly mediated via NMDAR antagonism. Its speculated that the cross tolerance is also a result opioid system activation but i wonder about these studies based on naloxone pretreatment. Wouldn't naloxone pretreatment reduce the analgesic efficacy of virtually any analgesic regardless of how it works (simply by inducing hyperalgesia through the castration of the endogenous opioid peptides)?

 

[jhjhsdi]

I think he's saying that already being on 3-MeO-PCP makes ketamine stronger, which is quite logical, and it certainly does, since it's mixing two dissociatives and they potentiate each other. But as far as tolerance, combining them will develop more tolerance over time than doing just one or the other.

I've found being on a high ish dose of pregabs can temporarily lower k tolerance/potentiate k.

Is nice.

 

[Hippy Flower Fairy]

Alcohol lowers my tolerance to ket while im drunk

Does the same to my ex mate, he'd be fucked and I'd be there sat bored watching him K'd off I'm his face, I think it's because your liver is trying to process the alcohol and the K at once so the K lingers for longer

 

[Hippy Flower Fairy]

I would say nopes. 3-meo more like should add tolerance to K rather than clear it. Dissos should reset tolerance to everything but dissos

I thought K annolouges ramped up your K tolerence too but never tried any RC but mxe, well I probably have but sold to me as K that I knew wasn't right

 

[jhjhsdi]

Does the same to my ex mate, he'd be fucked and I'd be there sat bored watching him K'd off I'm his face, I think it's because your liver is trying to process the alcohol and the K at once so the K lingers for longer

Does the trick mate. K tolerance getting high? Smash 4 cans on the way home from scoring, before you even do a bump....
Sometimes it would even be like a race, can i drink all 8 of these before matey gets here, etc
Makes the k way more interesting

 

[Hippy Flower Fairy]

Does the trick mate. K tolerance getting high? Smash 4 cans on the way home from scoring, before you even do a bump....
Sometimes it would even be like a race, can i drink all 8 of these before matey

No my tolerence is low again because the K here is so bad, worse than it's ever been, does nothing but headaches and sinus pain, abd and a streaming nose and I have lost out of alot of money for crap K then 2 days ago conned to the point a scammer took my £125 and sent nothing and you told me this before about alcohol but I don't drink, it's Flower Fairy here, Fairy of the Flowers on old profiles, hello again mate

 

[jhjhsdi]

2 days ago conned to the point a scammer took my £125 and sent nothing

What a cunt

and you told me this before about alcohol but I don't drink, it's Flower Fairy here, Fairy of the Flowers on old profiles, hello again mate

I guessed it was you pal yeah, I'm still on wickr if you want to chat about anything BL doesn't allow haha.
Surprises me no k your way, you aint exactly far and theres loads of good fine grain stuff round ere, been some shardy around recently too but its definitely not pure k it has some uppy feeling rc in it im sure, the fine grain is better and cheaper too!