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Misc Ketamine and Amitryptiline interaction

crOOk

Bluelighter
Joined
Dec 16, 2004
Messages
4,047
Location
Germany
The title pretty much says it all. What sort of interactions can be expected? Has anyone had experience taking Ketamine while being treated with Amitryptiline?
http://www.ncbi.nlm.nih.gov/pubmed/12620609 suggests Amitryptiline has a boosting effect on DXM, but not on Ketamine. Any info is appreciated!
 
i taken k binges while being on a steady 20mg amitryptiline (that tri cyclic antidepressant) for about 2 months. and have been fine.
 
Thanks a lot for the information. I ended up risking it since I couldn't find any info on pub med and both medications are widely used. Needless to say I was fine.
 
IMO...taking amitrytimine and Ketamine at the same time is beyond dumb. That's like shooting pool with death himself. Just my opinion though....Bluelight being a harm reduction site so im just saying if you wanna chance your health and neurological receptors etc. then be my guest. maybe people will learn..I learned and now im successful,and happy without using drugs and the best part im healthy....no drug is responsible for making me happy anymore....IMO, its time for you to quit the bs, and LIVE...you dont know what its like to live until your actually sober and making somthing of yourself and other people respecting you for it.
good luck
 
Thanks for those educated words (not). I've had 3 therapy sessions per week for 5 years, I've basically been trying to quit since I started. My whole life centers around running away from self hatred, alienation and loneliness and "just quitting" never worked out as planned. I just split up with the mother of my daughter, I'm for the first time living on my own without a woman around and the ketamine helped me to crawl out of the darkest depressive hole (hehe "hole", get it, get it?) I've ever been in. I thank god for that because regular antidepressants don't do the trick it seems. I'm studying medicine and got a lot of pressure on me atm. If it wasn't for the ketamine, I wouldn't have gotten my ass out of bed to start studying again, I wouldn't have met up with a woman yesterday (I kinda had a dry spell) and I wouldn't be going out there to meet with more women. Ketamine made me feel alive again and I am so thankful we have an antidepressant like that. I've last done it in december and I don't see anything wrong with that pattern of use. I'm trying to quit booze and opioids really hard and have been relatively successful so far.

Anyway, thanks a lot for your well meant, constructive advice (again: not). You might be better off posting on the dark side supporting other people instead of talking down to someone who's been trying desperately to get his life in order for years.

Edit: Do you even have any idea whatsoever, what Ketamine actually does to your brain? What the role of AMPA and NMDA receptors is in neuroplasticity? What 5-Methyl-Cytosine is? Don't talk about receptor systems if you don't know jack about them. Regular ketamine/pcp/dxm use might be really fucking bad for you (really really fucking bad), but I doubt you have even a rough idea of the antidepressant potential of a single ketamine dose and the biochemical consequences.

EDIT2: May I respectfully ask what you are doing on this site? Is your goal to actually reduce harm or are you playing with the thought of bouncing back to using? Because if you are trying to reduce harm you've definitely come to the right place, but your approach is (and I say this respectfully) entirely wrong. You're seemingly the victim of a misconception on what people's reactions generally are to someone offensively trying to influence their opinion and criticize their way of life. Hint: It's usually not, "Hey you're right. Why was I so blind to not see that? I will do as told."
 
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+ 1 for ketamine also.
Since ive been self medicating , i dont think of suicide every day anymore, i dont reach that doom and gloom point, and i do get less manic episodes. So it definately works!
 
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