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kava as and anticonvulsive?

M

mewmew2

Bluelighter
Joined
Oct 20, 2005
Messages
121
kava as an anticonvulsive?

I know not to trust the internet yada yada, but on Wikipedia it was claimed kava was an anticonvulsive...does anyone know if there's any truth to that at all?
 
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It makes sense that it does, considering most benzos have anti-convulsant properties. Kava is always described as being somewhat similar to diazepam (valium) in effect (on GABA at least). Diazepam does have anti-convulsant properties.
Kava is a weird complicated drug that works on a lot of different receptors and not all that much is known about it.
 
I agree, but alcohol effects gaba as well but doesn't prevent convulsions (unless you're an alcoholic). I've brought up a similar subject before, but the more you know....
 
There are many different binding spots when it comes to GABA. Kava is supposed to work on the same spots that benzodiazepines do. This is why I believe kava has the potential to have anti-convulsant properties, not just because it works on GABA.
 
in brief.......




GABAa receptor complex appears to have distinct binding sites for furosemide, neuroactive steroids, picrotoxin, barbiturates, ethanol, kavalactones, GHB, and inhalational anesthetics.

GABAb- beavioral actions of ethanol, gamma-Hydroxybutyric acid (GHB), and possibly in pain. Baclofen is a GABA analogue which acts as a selective agonist of GABAb receptors, and is used as a muscle relaxant. However, it can aggravate absence seizures, and so is not used in [many forms of] epilepsy. [maybe the same reason Phenobarbital is used so little as well?]

GABAc - Don't know much about this one, not modulated by many GABAa receptor modulators such as barbiturates, benzodiazepines, and neuroactive steroids



(adapted from wikipedia)



just incase anyone cares..... i learned something new today anyway...
 
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SWlM said:
in brief.......




GABAa receptor complex appears to have distinct binding sites for furosemide, neuroactive steroids, picrotoxin, barbiturates, ethanol, kavalactones, GHB, and inhalational anesthetics.

GABAb- beavioral actions of ethanol, gamma-Hydroxybutyric acid (GHB), and possibly in pain. Baclofen is a GABA analogue which acts as a selective agonist of GABAb receptors, and is used as a muscle relaxant. However, it can aggravate absence seizures, and so is not used in [many forms of] epilepsy. [maybe the same reason Phenobarbital is used so little as well?]

GABAc - Don't know much about this one, not modulated by many GABAa receptor modulators such as barbiturates, benzodiazepines, and neuroactive steroids



(adapted from wikipedia)



just incase anyone cares..... i learned something new today anyway...
Click to expand...

Interesting...so, kava would help someone with seizures due to ethanol w/ds, but not someone withdrawing from benzodiazepines?
 
^

Most benzodiazepines work on the GABAa receptor...so Kava should help with seizures associated with alcohol and benzo WD's.

I also know that benzodiazepines can be used to prevent seizures from alcohol withdrawal, but alcohol can't be used to prevent seizures from benzo withdrawal. I'm not sure why that is, I probably wasn't listening when it was explained.

I do known Kava has been used to assist in benzo and alcohol withdrawal, but it's effectiveness can vary.
 
kava feels nearly identical to valium or klonopin. seriously. i imagine it should have anti-convulsant properties, but thats just a guess, who knows? i do have a book on kava sitting right here................
 
^ what kinda dose do u need to take for those experiences?
i bought Kava Kava extract 30% full spectrum caps...200mg...
 
Thanks for everyones input and knowledge. I'm guessing there's no sort of equivalence table for kava for alcohol or benzo's, but subjectively, does anyone know the amount of kavalactones (i'm sure my spelling is wrong) to equal the normal equivalences to benzo's? I'll take this information as experience, not empirical evidence (even though that would be fantastic I know it's not realistic).

For example, what kind of dosage of a well known online supplier (i'm intentionally vague, sorry) of powder vs klonopin.

Thank you all for your input. Your knowledge is interesting as well as keeping possible seizures at bay, if that's even possible when w/d from benzos or alcohol. In this case I'm hoping Kava can help me buy some time.
 
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