Hi Guys:
I am trying to solve a mystery, at least it's a mystery to me.In the past 3 months I have intermittently taken the following opiates for my chronic pain: Tramadol, propoxyphene(not since I took a few too many though),methadone, oxycodone, hydrocodone, and morphine.Most of the time I only take tramadol or Hydro, because it's the easiest to get and seems to be the easiest on my body.My doctor has only given me Oxy-Contin a few times, but everytime I get my hands on ANY form of oxycodone it's always followed by a distinct ( because I have been through it too many times ) VERY INTENSE rebound depression/mood swings 12 or so hours after the LAST dose.
I just read this on Opioids.com:
"In addition, there is interest in the co-administration of opioids that act on different receptors. For instance, oxycodone appears to be a kappa opioid receptor agonist and may offer enhanced analgesia when combined with morphine. . ."
I have read somewhere that the Kappa receptor is sometimes said to be associated with and to cause dysphoria, could this be the reason I get so depressed after coming off of Oxy? What is weird about it is that I can be taking something else that day, methadone, whatever , and I still feel bad.
I am getting where I almost refuse any form of oxy because it's the only drug that gives me this intense rebound depression.I almost dropped out of school last week: and all of a sudden I was better.
I didn't feel better till I started back on the Ultram.
I am talking cry all day long , can't get out of bed, can't do anything type of deppression.It never lasts more than 2 days though. I can always count on it being gone after it runs it's course.
It may be the fact that I was so used to taking Tramadol, then I got the Oxy which lasted a week or more, and I don't usually combine opiates now so I stopped taking it while I had the Oxy.I am just glad it is over, the depression that is.
Anyway, any input is appreciated.
~w
I am trying to solve a mystery, at least it's a mystery to me.In the past 3 months I have intermittently taken the following opiates for my chronic pain: Tramadol, propoxyphene(not since I took a few too many though),methadone, oxycodone, hydrocodone, and morphine.Most of the time I only take tramadol or Hydro, because it's the easiest to get and seems to be the easiest on my body.My doctor has only given me Oxy-Contin a few times, but everytime I get my hands on ANY form of oxycodone it's always followed by a distinct ( because I have been through it too many times ) VERY INTENSE rebound depression/mood swings 12 or so hours after the LAST dose.
I just read this on Opioids.com:
"In addition, there is interest in the co-administration of opioids that act on different receptors. For instance, oxycodone appears to be a kappa opioid receptor agonist and may offer enhanced analgesia when combined with morphine. . ."
I have read somewhere that the Kappa receptor is sometimes said to be associated with and to cause dysphoria, could this be the reason I get so depressed after coming off of Oxy? What is weird about it is that I can be taking something else that day, methadone, whatever , and I still feel bad.
I am getting where I almost refuse any form of oxy because it's the only drug that gives me this intense rebound depression.I almost dropped out of school last week: and all of a sudden I was better.
I didn't feel better till I started back on the Ultram.
I am talking cry all day long , can't get out of bed, can't do anything type of deppression.It never lasts more than 2 days though. I can always count on it being gone after it runs it's course.
It may be the fact that I was so used to taking Tramadol, then I got the Oxy which lasted a week or more, and I don't usually combine opiates now so I stopped taking it while I had the Oxy.I am just glad it is over, the depression that is.
Anyway, any input is appreciated.
~w
