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Kanna with other psychedelics

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scabbard

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I'm doing a 5MeO-DMT retreat in a couple of weeks, and I'm planning on taking MDMA maybe an hour or so before the 5MeO-DMT to increase the likelihood of having a positive experience.

For the last 2 weeks, I've been taking a daily Kanna supplement, 15mg a day of a concentration that contains 13% mesembrine (~2mg of mesembrine total per dose).

I know Kanna is an SRI, and I'm slightly concerned about the possibility of serotonin syndrome when taking it with other psychedelics.

Do you think there's there a risk of continuing to consume it up until the day of the retreat? If you think I should stop in advance, how many days should I stop taking it for prior to the retreat?
 
Pretty much every time I trip I rip a piece off my kanna plant and chew it before or during the trip. It's good. Maybe adds to stimulation, but shouldn't be dangerous. I would do the 5 meo alone first, but if you have, a kanna combination could be nice. It's not the most pronounced psychoactive I've.
Serotonin syndrome isn't really a concern unless you're doing MAOIs or research chemical/more obscure full agonists of serotonin.
 
daturetard said:
Pretty much every time I trip I rip a piece off my kanna plant and chew it before or during the trip. It's good. Maybe adds to stimulation, but shouldn't be dangerous. I would do the 5 meo alone first, but if you have, a kanna combination could be nice. It's not the most pronounced psychoactive I've.
Serotonin syndrome isn't really a concern unless you're doing MAOIs or research chemical/more obscure full agonists of serotonin.
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I've done 5 before, by itself as well as with MDMA, and 2C-B for that matter. We'll see what happens when in a couple weeks when I combine it with MDMA and with the low dose of Kanna.

I've taken 2C-B probably 8 times now, always 20mg (+/- a little bit depending on the readout on my scale). For what it's worth, I took my standard 20mg dose today and I've never had such a profound experience in my life. Not sure if it was just the right day for me, or if it was related to the Kanna. Felt like more expansion of consciousness in 2 hours than I've had in the previous 30 years of my life.
 
scabbard said:
I've done 5 before, by itself as well as with MDMA, and 2C-B for that matter. We'll see what happens when in a couple weeks when I combine it with MDMA and with the low dose of Kanna.

I've taken 2C-B probably 8 times now, always 20mg (+/- a little bit depending on the readout on my scale). For what it's worth, I took my standard 20mg dose today and I've never had such a profound experience in my life. Not sure if it was just the right day for me, or if it was related to the Kanna. Felt like more expansion of consciousness in 2 hours than I've had in the previous 30 years of my life.
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If you're also using Mdma don't even bother with kanna. It will not give you more effects. It's so weak in comparison to mdma that it will literally do nothing but be placebo and waste expensive plant material.
 
daturetard said:
If you're also using Mdma don't even bother with kanna. It will not give you more effects. It's so weak in comparison to mdma that it will literally do nothing but be placebo and waste expensive plant material.
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I've been using a daily Kanna dose to try and get some balance in my nervous system on a regular basis (independent of this particular upcoming retreat). I will be taking MDMA the day of specifically for support during the experience. My initial question was related to whether or not the combination of the MDMA, the 5MeO-DMT and the Kanna could be problematic. My only reservation about discontinuing the Kanna in the days leading up to the experience is that I could experience some form of withdrawal, which I know is common with standard SSRI medications, and I don't want to be feeling that way on the day of.
 
scabbard said:
I've been using a daily Kanna dose to try and get some balance in my nervous system on a regular basis (independent of this particular upcoming retreat). I will be taking MDMA the day of specifically for support during the experience. My initial question was related to whether or not the combination of the MDMA, the 5MeO-DMT and the Kanna could be problematic. My only reservation about discontinuing the Kanna in the days leading up to the experience is that I could experience some form of withdrawal, which I know is common with standard SSRI medications, and I don't want to be feeling that way on the day of.
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Kanna is not the type of drug you'll be feinding for or you're addicted to. You won't experience wd. It's more potent as a VMAT-2 unregulator than it is as an sri. Also a PDE inhibitor. There are case reports of mild withdrawal, as with any psychoactive used long term.
 
Kanna isn't a psychedelic.

Is it a thing to group it in "psychedelics" because it's a "nature spirit" because it's a plant or something?
 
I've only ever dealt with Kanna in 300x-500x concentrates, so I'll be speaking on this realm of super heady concentrates in my response here, just a heads up.

I've mixed it with a handful of psychedelics, but mixing it with MDMA left me grinding my teeth damn near flat, unable to form meaningful thoughts, pouring sweat for quite a while. I suspect that I was approaching a terribly dangerous point of serotonin syndrome but I couldn't tell tbh. I just rode it out and ended up being fine, at least from my own perspective. Mixing Kanna with psychedelics (specifically that lack MAOI and monoamine releasing properties) has been nice, often adding a pleasant stimulation and sometimes seemingly potentiating the effects of mushrooms, 2C-B, and LSD, but only very mildly.

Taking half a gram of ~400x Kanna extract put me in what I can only refer to as a damn near psychotic roll of pure rage and emotionality. A former best friend had emotionally led me on for months, only later admitting that he just uses gay men for sex when he's bored. That roll made it very difficult not to act towards him with extreme violence. All five of the people I was living with were absolutely terrified of my behavior towards all of them too, as recently a local spice addict (we colloquially referred to them as spice zombies) had fallen through my window late at night in what seemed like a breaking and entering attempt. My trusty pocket knife and I handled this situation, solo, because each and every one of them were too bitchmade to even peeek into my bedroom (door was both open and unlocked), and after me screaming at them to get in there, they decided instead to stay locked in their rooms out of fear.

If MDMA, MDA and 6-APB (the other three empathogens I've used excluding oxytocin which is like an empathogenic whippet) allow your emotions to come out like a controlled release from a series of dams with gates on levers that you can precisely control as far as the outwards flow of emotionality, Kanna is instead just exploding every single damn and letting them flow out completely uncontrollably. I was pacing around my living room for literally hours, screaming every feeling I'd had and felt that I didn't think would be right to have communicated at past points, it was like an explosion of built up tension. The eugeroic effects were interesting too, two drinking glasses got accidentally chipped on the sink just trying to fill them up (I was shaking like crazy) and a plastic cup literally exploded in my hands from an accidental overexertion of force. I also put my hands on the edge of a wooden coffetable and it bent, I had to bend it back and apply polyurethane and then spray lacquer to get it normal again.
 
Esperighanto said:
I've only ever dealt with Kanna in 300x-500x concentrates, so I'll be speaking on this realm of super heady concentrates in my response here, just a heads up.

I've mixed it with a handful of psychedelics, but mixing it with MDMA left me grinding my teeth damn near flat, unable to form meaningful thoughts, pouring sweat for quite a while. I suspect that I was approaching a terribly dangerous point of serotonin syndrome but I couldn't tell tbh. I just rode it out and ended up being fine, at least from my own perspective. Mixing Kanna with psychedelics (specifically that lack MAOI and monoamine releasing properties) has been nice, often adding a pleasant stimulation and sometimes seemingly potentiating the effects of mushrooms, 2C-B, and LSD, but only very mildly.

Taking half a gram of ~400x Kanna extract put me in what I can only refer to as a damn near psychotic roll of pure rage and emotionality. A former best friend had emotionally led me on for months, only later admitting that he just uses gay men for sex when he's bored. That roll made it very difficult not to act towards him with extreme violence. All five of the people I was living with were absolutely terrified of my behavior towards all of them too, as recently a local spice addict (we colloquially referred to them as spice zombies) had fallen through my window late at night in what seemed like a breaking and entering attempt. My trusty pocket knife and I handled this situation, solo, because each and every one of them were too bitchmade to even peeek into my bedroom (door was both open and unlocked), and after me screaming at them to get in there, they decided instead to stay locked in their rooms out of fear.

If MDMA, MDA and 6-APB (the other three empathogens I've used excluding oxytocin which is like an empathogenic whippet) allow your emotions to come out like a controlled release from a series of dams with gates on levers that you can precisely control as far as the outwards flow of emotionality, Kanna is instead just exploding every single damn and letting them flow out completely uncontrollably. I was pacing around my living room for literally hours, screaming every feeling I'd had and felt that I didn't think would be right to have communicated at past points, it was like an explosion of built up tension. The eugeroic effects were interesting too, two drinking glasses got accidentally chipped on the sink just trying to fill them up (I was shaking like crazy) and a plastic cup literally exploded in my hands from an accidental overexertion of force. I also put my hands on the edge of a wooden coffetable and it bent, I had to bend it back and apply polyurethane and then spray lacquer to get it normal again.
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Wow, thanks for the details. The eugeroic effects sound very interesting. That's amazing. Obviously the doses you took were probably more than a hundred times the amount that I'm taking, so it's not even in the same league, but interesting nonetheless.
 
scabbard said:
Wow, thanks for the details. The eugeroic effects sound very interesting. That's amazing. Obviously the doses you took were probably more than a hundred times the amount that I'm taking, so it's not even in the same league, but interesting nonetheless.
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This was after about 1.5 years of just doing bodyweight exercises and skateboarding after 2 years of genuinely psychotically intense powerlifting. The kind of powerlifting where I actually only ate peanut butter, protein shakes, and beef jerky for months on end. Ramen only if I desperately needed salt, usually alongside some hyper-dense solutions of gatorade powder in water. During that period I also frequently used GHB before sleep intentionally as an HGH secretagogue. When covid happened, I thought to myself "hm, well I'm immunocompromised because of Crohn's disease, I guess I'm going skatermode now, so I can skate alone in parking lots instead of being masked up in a cramped gym".

It was very unlike me in the phase of life that I was in to be exerting powerlifter ape strength, yet kanna elicited it like it was not a problem at all. I could see kanna's applications with our ancestors hunting for sure, hell I could see it being used in combat situations to this day. It made time slow in that way that it does when death is near as well, it was quite peculiar.
 
It's a very strange material. After trying it at normal levels off and on for almost 30 years, it'd never done anything to speak of. If it hadn't worked so magically to mitigate MDMA hangovers, I likely would have written it off completely. Recently, I decided to revisit the branded oral Tristill extract. After three days, it was definitely doing...something. A weird sort of anxiolysis maybe? A sense of well-being and of feeling more present in the moment, unable to ruminate much on the past or future.

I learned that in 2025, much has changed. You can get extracts with varying mesembrenone to mesembrine ratios, targeting effects that are more empathogenic or euphoric or sedating. I decided to get some potent extracts and try insufflation. Just starting with that, so I have a lot to learn and explore.

Yesterday, I combined insufflating 10mg of a high mesembrenone extract with some EPT and some delta-8-THC. It was lovely and warm and enjoyable, and I look forward to exploring it again. The extract reminded me a little of aMT (in a world where I looked aMT.) I'm now quite curious about how various kamna extracts might combine with psychedelics.
 
daturetard said:
Serotonin syndrome isn't really a concern unless you're doing MAOIs or research chemical/more obscure full agonists of serotonin.
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But arguably kanna, MDMA, and 5-MeO-DMT should be mixed with an MAOI—cautiously…

https://www.bluelight.org/community/threads/kanna-flips.941343/post-16288295

Using MDMA as a substitute for DMT in ayahuasca

5-MeO-DMT ⇩
“I have heard very mixed reports from trials employing P. harmala and the second of the biotic tryptamines, 5-methoxy-N,N-dimethyl-tryptamine, or 5-MeO-DMT. Apparently, modest amounts of both components gives a modest experience, but I have had two reports of truly toxic crises with larger quantities.”

Alexander Shulgin. TiHKAL (part 1). Shulgin A, Shulgin A. 1997 16. Hoasca vs. Ayahuasca, pg. 302

“For his study, Markus mixed a representative of the β-Carbolins (harmin, harmalin, or 6-MeO-harmalan) with a tryptamine (5-MeO-DMT). He found a domain of optimal mixtures in which marked psychoactive productivity was associated with hallucinatory effects. Within certain specific ranges of dosage, the mixture was well-tolerated and there were no serious side-effects.”

‘A report on the symposium “On the Current State of Research in the Area of Psychoactive Substances”’. Hanscarl Leuner & Michael Schlichting [The Gateway to Inner Space: A Festschrift in Honor of Albert Hofmann. Christian Rätsch (ed.), 1989. Bridport, England: Prism Press] page 237


"I on the other can positively attest that I’ve done the combination with quite a few others and all of us had the best experiences ever."

divinemystictemple, 2021-04-26, reddit.com/r/5MeODMT
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Pfafffed said:
It's a very strange material. After trying it at normal levels off and on for almost 30 years, it'd never done anything to speak of. If it hadn't worked so magically to mitigate MDMA hangovers, I likely would have written it off completely. Recently, I decided to revisit the branded oral Tristill extract. After three days, it was definitely doing...something. A weird sort of anxiolysis maybe? A sense of well-being and of feeling more present in the moment, unable to ruminate much on the past or future.

I learned that in 2025, much has changed. You can get extracts with varying mesembrenone to mesembrine ratios, targeting effects that are more empathogenic or euphoric or sedating. I decided to get some potent extracts and try insufflation. Just starting with that, so I have a lot to learn and explore.

Yesterday, I combined insufflating 10mg of a high mesembrenone extract with some EPT and some delta-8-THC. It was lovely and warm and enjoyable, and I look forward to exploring it again. The extract reminded me a little of aMT (in a world where I looked aMT.) I'm now quite curious about how various kamna extracts might combine with psychedelics.
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I've never thought to use it on MDMA hangovers, but the mixture of psilocybin containing fungi, high doses of Kanna extract vaporized or insufflated, and a separate tea that I sip over the day with coca, chai and lotus in a base of mushroom tea, it felt like the hippie-er version of the famous hippie flip.

I have yet to try an extract that's not full spectrum, I'll have to get back into it soon! I would love to, though it can be rough with Bupropion so I'll have to let this shit get out of my system first. I love Bupropion but it hangs around forever, which is occasionally inconvenient.

I think I'll try everything I've got except Ayahuasca, 5-MeO-DiPT, 25I-NBOMe and 25B-NBOH. That leaves DPT, DOM, DOB, DiPT, 4-HO-MET, 4-AcO-DMT, 4-HO-MiPT, 4-HO-DET, Allylescaline, 2C-B, HBWR, Mushrooms again just to visit back on an old favorite, and almost certainly some others I'm forgetting because I'm relatively barred out right now on etizolam.

Any recommendations on how you'd shape set, setting, or intention for it? And which of the three RoAd (oral, vaporized and insufflated) do you think should be focused on here?
 
Esperighanto said:
Any recommendations on how you'd shape set, setting, or intention for it? And which of the three RoAd (oral, vaporized and insufflated) do you think should be focused on here?
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I'm brand spanking new to it, so I can't provide any useful information with any authority. You've already pushed doses orders of magnitude past the point where kanna causes dysphoria in most users (which isn't very high with extracts,) so I'm not sure that you can even borrow much from other user reports. I wish I could, but I'm only just learning and exploring myself!
 
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