Juice and Pill Interactions

[MOralDosing]

I'm sure a lot of people know that different juices have effects in the digestive system, which in return can increase or lengthen the effects of pills during digestion, or have little to no effect at all. Also noted, that there is danger involved, like there is with most anything we ingest. I couldn't find a clear thread on the absolute and clear facts, or a thread completely contributed to juices effects on pill ingredient absorption. Hopefully we can come up with a chart or just a good amount of comments from individual members that anyone can compile personally. I believe it is knowledge everyone should know. If I missed a thread with these specifics, please re-direct me and then close the thread, I just couldn't find a good source of full information. So hoping we can make that here.

So as far as I know is grapefruit juice can increase the absorption process and intensify or lengthen the effects of certain benzos, due to the juices effect on digestion... yada yada. From what I've seen (as far as benzos) is that only a few benzos are really effected by grapefruit juice. Two of the most popular benzos, Alprazolam and Clonazepam ( Xanax and Klono... well you know what they are lol). Study from Harvard shows that Klonopin shows little to no effect with drinking grapefruit juice, however Xanax has been shown to be more impacted by the effects of grapefruit juice working in the stomach.

Here's what I'd like to add for information to compile:

What other pills are effected by different juices besides, and including Benzodiazepam

What are the different juices or citric "liquids" or "solids" that effect pills in general.

How do they effect the pills absorption, increase or decrease, and especially, what are the possible dangers that can occur because of the mixtures?

I appreciate anyone and everyones input. I think this would make a good source page because I see a lot of people don't have full knowledge of these things. We are all pros when it comes to drugs, that's why we're here. We have all had some intense experience either personally or vicariously. This is something I first heard of a few years ago with the old myth of drinking orange juice with ecstasy for a better high and come down. I never researched or pursued the truths of it, but out of the 100's of E rides, there was of course a few bad ones. If I had the definite knowledge back then that orange juice could have saved me from a bad trip, it would have saved me a few panic attacks! That's why I think this compilation of mixtures is important information to gather. Let me know what you guys think. The more input the better.

Negative or positive, I'm not judgmental and don't fight back lol so be mean and call me an idiot, or agree that this info holds value to have all in one place. Thanks in advance for those of you who add helpful information to this thread,

Thanks



Klaus~

 

[Psychonauticunt]

Grapefruit and grapefruit juice (I think the pink ones contain a little bit, but the white ones have it in abundance) and fruits like pomelo inhibit the action of CYP3A4, the enzyme responsible for the metabolism of many drugs. When the enzyme is inhibited, then essentially the drug does not metabolize at all for a while, or does so at a greatly reduced rate - this leads to intensified and prolonged effects.

There is some varying information on exactly which drugs are affected, and the exact mechanisms of action of certain drugs are unknown (eg. whether the parent compound is inactive or significantly less active than its metabolite), so there is some dispute. However, from conventional knowledge, confirmed by my personal experiences, at least the following are potentiated:

Oxycodone
Methadone

Nitrazepam, clonazepam, flunitrazepam (nitrobenzodiazepines)
Triazolam
Midazolam
Alprazolam
Diazepam

(Meth)amphetamine
Methylphenidate

I can't confirm the amphetamines or methylphenidate, but in my personal experience all of those depressants I listed have been potentiated - some slightly, some significantly - by grapefruit.

EDIT: Only after I typed all that did I decide to Google "grapefruit drug" - could have saved myself a bit of time. Here:

http://en.wikipedia.org/wiki/Grapefruit–drug_interactions

 

[BlueIV]

I recall a news reporting on a study though found it's more widespread than thought; it's not just grapefruit juice. I don't think I ever went to the actual study though. Does this sound familiar to anyone else?

 

[MOralDosing]

Thank you for the more in-depth facts, as well as added drugs that are effected! @Psycho, and Blue IV, yes! Thanks for bringing that up. Like I said, I heard of drinking orange juice with X for a better high and come down. I'm really interested to know exactly what other fruits (names particulary, not the different acids or chemicals) have an enzme type effect or any effect on that matter, on pills and other substances.
EDIT: Sorry forgot to say thanks, and any input is appreciated!