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Opioids IV / injecting Loperamide

I just read through the thread you linked to in the OP, and I am actually dumb-founded. Slamming super-glue and Immodium?
Lol, I didn't even notice that linked thread for some reason, but apparently the guy in that thread read the same study that I quoted above and decided that "loperamide-containing nanoparticles coated with polysorbate 80" = loperamide pills + superglue?!?

Nanoparticles are just really tiny particles of pure loperamide. And polysorbate 80 is a surfactant, used presumably make the lope dissolve better. I have no idea why he thought glue should be involved! In addition, it should be noted that even in this study they did not note euphoria being attained.
 
Unbelievable dude, you want to IV loperamide? It's so much less risky to just ride out some withdrawal symptoms of your unknown drug of choice, unless it's methadone or buprenorphine, and then still, loperamide is not an option.

How about you do your body a favor and stop abusing intravenous drugs.
 
^ Yeah it is but the central effects of high-dose loperamide are well established. The science is simple - low doses do not produce central effects because a negligible amount remains in the brain due to P-gp but with sufficiently large doses, enough remains to produce significant central opioid effects. Inhibiting P-gp with substances such as piperidine (found in black pepper) are proven to increase the central effects loperamide produces.

can you tell me where you found the info on black pepper inhibiting p-gp and when/how much to dose with it before ingesting loperamide?
 
Black pepper contains piperine (typically 5-9% ). Here is a good starting point.

Piperine has also been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites.[9] In animal studies, piperine also inhibited other enzymes important in drug metabolism.[10][11] By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds and alter the effectiveness of some medications.[10] Notably, piperine may enhance bioavailability of curcumin by 2000% in humans.[12] The exact mechanism of piperine's bioavailability enhancing abilities is unknown.[13]]


I can't attest to the safety of taking large doses of black pepper and wouldn't want to hazard a guess.

I wouldn't recommend fucking with P-gp inhibitors and loperamide... there is no way to predict the piperine content of YOUR black pepper or how much stronger it will make the loperamide. Even if a lot more loperamide becomes centrally active, it's not going to make imodium feel like heroin. It's not a good "high" even when substantial opioidergic effects are acheived.
 
Black pepper contains piperine (typically 5-9% ). Here is a good starting point.

Piperine has also been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites.[9] In animal studies, piperine also inhibited other enzymes important in drug metabolism.[10][11] By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds and alter the effectiveness of some medications.[10] Notably, piperine may enhance bioavailability of curcumin by 2000% in humans.[12] The exact mechanism of piperine's bioavailability enhancing abilities is unknown.[13]]


I can't attest to the safety of taking large doses of black pepper and wouldn't want to hazard a guess.

I wouldn't recommend fucking with P-gp inhibitors and loperamide... there is no way to predict the piperine content of YOUR black pepper or how much stronger it will make the loperamide. Even if a lot more loperamide becomes centrally active, it's not going to make imodium feel like heroin. It's not a good "high" even when substantial opioidergic effects are acheived.


I disagree. I mean you know your heroin purity rouglhy if you got a steady supply. Same with your pepper. I usually cover a piece of whole wheat toast evenly with ALOT of pepper, eat, drink water, then chew up some lope.
 
Wat? The lengths that some people will go through to get high is beyond me...

Assuming it was safe, which I'm pretty sure it's not, can you imagine the intense constipation from IV lope if you start chasing that "high"? 8o

Once you have neuropathy and chronic pain from using opiates so long its not about a high but an ability to function without your CNS sending you into a depression. You should be thankful you have no pain.
 
^ wat? :?

It's one thing to hold yourself with lope so you won't get diarrhea or physical wd symptoms, but we're talking about using it recreationally here... welcome to BL, btw :)
 
Please don't IV Loperamide, dude (OP and ANYONE considering this out of sheer desperation/boredom/whatever). It's pointless and very dangerous. Take it orally and enjoy not having to deal with all of the physical withdrawal symptoms.
 
I can't believe some of the shit I've read about the lengths people have gone to get high off of lope. And it makes me seriously wonder the long term effects of abusing it, whether to just ease WD or recreationally (god knows why).
 
Please do not iv that. To get some dope, feel great, save that for when you don't.


Or like someone else said....iv some water, eat the pills.
 
I.v.ing anti-diarrhea pills... why didn't I think of tgat?

jk, as outrageous as it sounds with proper filtration and technique I would be surprised if anything went drastically wrong. don't take that as gospel though, just my opinion
 
I have tried the propionyl ester, twice, which proved a fairly strong opioid of central action.

But you do NOT want plain unmodified loperamide to cross the BBB, and stay there.
The reason for its toxicity, is that it forms a charged metabolite, LPP+ in-vivo, like the MPP+ from MPTP (look up 'the case of the frozen addicts', cases of permanent parkinsons disease that occurred in some clan. chemists that synthesized a reverse ester of one of the prodines, a pethidine/meperidine derivative. Only the guy doing it tried speeding up the reaction by increasing the temperature, resulting in an elimination rxn of one of the intermediates, dehydrating to the tetrahydropyridine derivative, which promptly blew his substantia nigra to pieces.) or the similarly working nasty metabolite from the antipsychotic haloperidol HPP+.

All parkinsons-inducing, nasty metabolic poisons.
 
Aside from somebody mentioning pig fetuses and LC right before me, no one can articulate why exactly is loperamide dangerous. If there were known fatalities or complications, please detail these episodes if possible.
 
Many anecdotes of terrible, endless withdrawal after sustained use of ultra high doses (100-200mg) and onefatality of a beloved member of bluelight likely due to combining high dose lope with alcohol. It certainly isnt harmless. Great tool in the kit, sure, but don't treat it like candy.
 
Did propanoyl-loperamide feel similar to dilaudid? I found that Acetyl-Loperamide is very much like dilaudid or morphine without the pins and needles after that rush.
 
Blue light is the largest concentration of condescending never me types in existence.
So why are you wasting your precious time here?
The staff on this site are all volunteers, and all work hard to help make HR information freely available.

We've had several deaths in this community from loperamide.
Have some respect for the site and its users, stop giving out idiotic, life threatening advice or kindly GTFO.
 
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