sixpartseven
Bluelight Crew
IV Buprenorphine/Antihistamine FAQ
The last thread was lost (not really "lost" - I accidentally deleted it after making a huge mess of it...it's a long story) but with a little help from my co-Mods, a copy was found using Google and I have reposted it.
For more buprenorphine and suboxone information: Suboxone/Buprenorphine FAQ by Phrozen
Why would anyone IV antihistamines with buprenorphine?
Most people who use buprenorphine are on it in a maintenence program. Considering that, there is a good chance that their tolerance is pretty high. For opiate naive users, buprenorphine does provide a high although some consider it not to be a typical high. However, users dont get those effects. IVing buprenorphine and antihistamines together can provide a tolerant user with a rush and a high. Some may say its not comparable to other opiates such as heroin or oxycodone, but to someone who doesnt get to experience a high every now and then without having to resort to other opiates, now has the ability to do so. edit thanks to phrozen
Anyone considering doing this should reconsider. In the end, its not worth it, but this is for those who insist on trying it.
Which antihistamine containing products are best for me to use?
This will depend on what country you are in. In the United States, the only usable antihistamine that can be found over the counter is Diphenhydramine. Diphenhydramine comes in a variety of products, but there are really only two viable options for IV use. Bendryl capsules (not the pink tablets) are one and Sleepinal capsules are another. Its suggested to use Sleepinal brand because it has less fillers in it (Benadryl contains gelatin and other nasty fillers) and because it contains 50mg diphenhydramine compared to Benadryls 25mg diphenhydramine.
The above includes antihistamines available outside of the USA thanks to JasonCrest.
A warning about IV Promethazine (thanks to splenda)
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/psn/transcript.cfm?show=93#1
Is this even safe to do?
Its not safer than the use of any other pills via IV administration. There are added risks if you are using Suboxone brand buprenorphine because of the coloring and flavoring used in the pills. Its suggested to not do this at all if you only have access to Suboxone, but in the end, that decision will be up to you. When shooting any pill, you always have the increased risk of infections if you miss the shot. Cases of necrotizing fasciitis, gangrene, and pulmonary granulomas, which is probably one of the biggest causes of death when shooting pills, have been reported due to missed shots of Suboxone and shots accidently injected into an artery.
edit thanks to phrozen
So Im trying to make a solution with my antihistamines but Im having trouble getting it dissolve in the water?
Due to a lot of fillers placed inside the capsules, you will have a lot of undissolved powders in your solution. The best way to get maximum amount of product out and not lose any water is to empty the contents of the capsule into 1ml of water. Stir it up a little bit, then allow it to sit for 10 minutes. After 10 minutes, you will see two layers in the spoon or cup you are preparing it in. Place your filter into the solution, trying to keep it from touching the bottom layer of powder (the powder tends to become gel-like and clog the bottom of the filter.) Draw up as much solution as possible. Once you’ve gotten most of the water out, there will still be some water in the undissolved powder. Move a fresh filter around in the powder, allowing it to draw in as much water as possible, then try and draw that water out of the filter with your syringe. You will lose some water. Its a fact of life in this situation. Thats why I say use 1ml. Ive been able to get .9ml back, but sometimes it isnt that easy.
How much water should I use when preparing antihistamines?
You can use as much or as little water as you wish. Diphenhydramine is freely soluble in water and Buprenorphine will have no problem going in to solution either. Chances are, you aren’t using so much Buprenorphine that some of it wont go in to solution. Id suggest using 1ml , but you can use up to 2ml. I say this because any less water is going to make it more difficult when trying to prepare the antihistamine.
Should I dissolve the bupe and antihistamines at the same time?
No. Its suggested to prepare them one at a time. The antihistamine should be done first, then crush the buprenorphine up in a cup or spoon, and use the solution of antihistamine to dissolve the buprenorphine. This will keep you from losing a lot of product due to clogged filters and the usual loss of water when preparing drugs for IV.
How much of what antihistamine should I use?
If you are using diphenhydramine and this is your first time ever using it IV, use no more than 30 – 35mg. Otherwise, 50mg is suggested, but no more than 150mg per day.
How much bupe should I use?
Use no more than you would if you were using it sublingually or intranasally so you don’t increase your tolerance too much. You can use more, but be smart when doing so. Remember that when using buprenorphine IV, negative side effects are more pronounced if you go above 8mg at once. You still may use more than 8mg, but take into consideration your tolerance.
For example:
Its suggested that if you are going to IV this multiple times a day, to first of all reconsider that idea. However, if you still choose to, try to do the most youll use in the first shot of the day.
For example:
I use about 8mg throughout an entire day. My first shot for the day will be 4mg. Throughout the day, I will do two more shots of 2mg each.
You also have to consider how much diphenhydramine you will be using. Since I do three shots a day, I can use 50mg per shot, totaling out to 150mg per day. If you plan on doing 4 or 5 shots a day, you need to take that into consideration, because if you use 50mg of diphenhydramine per shot, youll be using 200mg – 250mg per day. When you get that high in dosage, anticholinergic effects begin to take hold, causing delirium.
After preparing the antihistamine, how do I add the bupe to it?
As stated above, the best way to do this would be to prepare a solution of antihistamine only then in a separate spoon or cup, crush the buprenorphine up. Add the solution of antihistamine to it, stir, filter, and draw up.
My solution is still really cloudy, what does this mean?
Its suggested to use micron filters when preparing pills for IV. Some people don’t have access to micron filters, but coffee filters would be the next best thing. All you have to do is load an empty syringe with stacked pieces of the filter which have been cut to the diameter of the syringe. Then, you just squirt the liquid through the filters multiple times. Q-tip cotton will also work, but I suggest to not use them unless you absolutley have to. Cigarette filters should not be used. Due to all the other fillers in most antihistamines, you will end up with a cloudy solution after you first draw it up. It is highly suggested to filter this solution multiple times before adding the buprenorphine to it. Filter it until you have an almost clear solution. You wont be able to get it crystal clear, but get it as close as possible. ALWAYS USE A MICRON FILTER IF YOU HAVE ACCESS TO THEM. edit thanks to phrozen
Im using suboxone, and my solution is still really orange, what does this mean?
Suboxone is different than Subutex because it will leave you with an orange solution. It looks nasty, but there is a way to tell if you’ve gotten a good proportion of particulate out of solution. Even though its orange, you can still get it to a point where it will be clear. Youll be able to tell when its there by holding the needle up, numbers facing away from you, and if you can read the numbers on the opposite side, then that’s a good way to tell if you’ve gotten most of the particulate out. Remember, this is not a fool proof way to tell if it doesn’t have particulate matter in it. Its just a way to gauge how well its been filtered. The same suggestions for filtering the diphenhydramine apply here also. ALWAYS USE A MICRON FILTER IF YOU HAVE ACCESS TO THEM. edit thanks to phrozen
So my solution is ready to be injected, are there any extra precautions I should take?
Injecting this solution is more dangerous than injecting a drug like heroin or cocaine. What can come from a missed shot could be disastrous. Be sure you wont be distracted and that you can take your time when injecting so that you don’t miss.
When I injected the solution, it burned really bad. Does this mean I missed?
No. Antihistamines burn when injected. You can use this to your advantage.
I think I may have shot into an artery, how can I know for sure?
This is how you can use the burn from antihistamines to your advantage. Veins flow up the arm, towards your heart, while arteries carry blood towards your hands. If you feel the burn moving up your arm, towards your shoulder, you were in a vein. If you feel it move down your forearm towards your hand, you hit an artery. Also, if shot into an artery, it will be extremely painful. Your hand will begin to swell, and most times go numb.
Besides obvious health risk from IV drug usage, what extra health risks do I have to worry about when injecting these specific drugs?
Some fillers and binders in Subutex and Suboxone are known to be vesicants. Vesicants cause damage to the veins from the inside out. Arterial shots of Subutex and Suboxone have also been known to cause infections resulting in gangrene and ultimately amputation of the arms or hands. Missed shots carry the same risks as missed shots of any other pill, such as abscess and possibly gangrene resulting in amputation if not treated. If you feel you have missed a shot or shot into an artery, seek medical attention immediately.
Is the duration effected by using buprenorphine IV?
Yes. Due to different rates of absorption, the duration will be effected. Anecdotal reports suggest the duration is around 8 – 12 hours, compared to 18 – 24 with intranasal administration, and 24 – 36 with sublingual administration. Take this into consideration before going through with this. It is quite possible to run through a supply of buprenorphine before being able to get a refill due to over usage of the drug. If you are on maintenance and depend on your buprenorphine, please think extra hard before doing this. Make sure you will be able to ration your supply so you aren’t left without any way too early.
Is this a good way to use buprenorphine when speciffically trying to maintain a habit or is should this only be done when trying to get high?
If you are maintaining a habit, the best advice would be to use the drug as directed. There is nothing worse than running out of your drug before you are able to get a refill. If you feel you are at a point in your maintenance that you can afford to spare a pill or two to get high every once in a while, then this is exactly what combining antihistamines and buprenorphine is good for.
If you aren’t opiate dependent, please consider your tolerance before trying to IV these drugs. Buprenorphine is a very potent drug and could cause an opiate naïve user to overdose. Also consider how long ago you have last used a full agonist such as heroin or oxycodone before using IV buprenorphine. If you are opiate dependent but not on maintenance, IVing buprenorphine within 36 hours of your last dose of the full agonist will cause precipitated withdrawals.
Can antihistamines be IVed with other opiates?
Absolutely. Any opiate that can be IVed on its own can be IVed with antihistamines added to it with great results. The same suggestion applies still: Do not exceed 150mg in a day
The last thread was lost (not really "lost" - I accidentally deleted it after making a huge mess of it...it's a long story) but with a little help from my co-Mods, a copy was found using Google and I have reposted it.
For more buprenorphine and suboxone information: Suboxone/Buprenorphine FAQ by Phrozen
Why would anyone IV antihistamines with buprenorphine?
Most people who use buprenorphine are on it in a maintenence program. Considering that, there is a good chance that their tolerance is pretty high. For opiate naive users, buprenorphine does provide a high although some consider it not to be a typical high. However, users dont get those effects. IVing buprenorphine and antihistamines together can provide a tolerant user with a rush and a high. Some may say its not comparable to other opiates such as heroin or oxycodone, but to someone who doesnt get to experience a high every now and then without having to resort to other opiates, now has the ability to do so. edit thanks to phrozen
Anyone considering doing this should reconsider. In the end, its not worth it, but this is for those who insist on trying it.
Which antihistamine containing products are best for me to use?
This will depend on what country you are in. In the United States, the only usable antihistamine that can be found over the counter is Diphenhydramine. Diphenhydramine comes in a variety of products, but there are really only two viable options for IV use. Bendryl capsules (not the pink tablets) are one and Sleepinal capsules are another. Its suggested to use Sleepinal brand because it has less fillers in it (Benadryl contains gelatin and other nasty fillers) and because it contains 50mg diphenhydramine compared to Benadryls 25mg diphenhydramine.
jasoncrest said:
The above includes antihistamines available outside of the USA thanks to JasonCrest.
A warning about IV Promethazine (thanks to splenda)
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/psn/transcript.cfm?show=93#1
Is this even safe to do?
Its not safer than the use of any other pills via IV administration. There are added risks if you are using Suboxone brand buprenorphine because of the coloring and flavoring used in the pills. Its suggested to not do this at all if you only have access to Suboxone, but in the end, that decision will be up to you. When shooting any pill, you always have the increased risk of infections if you miss the shot. Cases of necrotizing fasciitis, gangrene, and pulmonary granulomas, which is probably one of the biggest causes of death when shooting pills, have been reported due to missed shots of Suboxone and shots accidently injected into an artery.
edit thanks to phrozen
So Im trying to make a solution with my antihistamines but Im having trouble getting it dissolve in the water?
Due to a lot of fillers placed inside the capsules, you will have a lot of undissolved powders in your solution. The best way to get maximum amount of product out and not lose any water is to empty the contents of the capsule into 1ml of water. Stir it up a little bit, then allow it to sit for 10 minutes. After 10 minutes, you will see two layers in the spoon or cup you are preparing it in. Place your filter into the solution, trying to keep it from touching the bottom layer of powder (the powder tends to become gel-like and clog the bottom of the filter.) Draw up as much solution as possible. Once you’ve gotten most of the water out, there will still be some water in the undissolved powder. Move a fresh filter around in the powder, allowing it to draw in as much water as possible, then try and draw that water out of the filter with your syringe. You will lose some water. Its a fact of life in this situation. Thats why I say use 1ml. Ive been able to get .9ml back, but sometimes it isnt that easy.
How much water should I use when preparing antihistamines?
You can use as much or as little water as you wish. Diphenhydramine is freely soluble in water and Buprenorphine will have no problem going in to solution either. Chances are, you aren’t using so much Buprenorphine that some of it wont go in to solution. Id suggest using 1ml , but you can use up to 2ml. I say this because any less water is going to make it more difficult when trying to prepare the antihistamine.
Should I dissolve the bupe and antihistamines at the same time?
No. Its suggested to prepare them one at a time. The antihistamine should be done first, then crush the buprenorphine up in a cup or spoon, and use the solution of antihistamine to dissolve the buprenorphine. This will keep you from losing a lot of product due to clogged filters and the usual loss of water when preparing drugs for IV.
How much of what antihistamine should I use?
If you are using diphenhydramine and this is your first time ever using it IV, use no more than 30 – 35mg. Otherwise, 50mg is suggested, but no more than 150mg per day.
How much bupe should I use?
Use no more than you would if you were using it sublingually or intranasally so you don’t increase your tolerance too much. You can use more, but be smart when doing so. Remember that when using buprenorphine IV, negative side effects are more pronounced if you go above 8mg at once. You still may use more than 8mg, but take into consideration your tolerance.
For example:
- If you use 2mg at once, or 2mg multiple times a day, don’t exceed 4mg – 6mg at once, or 4mg – 6mg multiple times a day.
- If you use 8mg at once, or 8mg multiple times a day, don’t exceed 12mg – 16mg at once, or 12mg – 16mg multiple times a day.
Its suggested that if you are going to IV this multiple times a day, to first of all reconsider that idea. However, if you still choose to, try to do the most youll use in the first shot of the day.
For example:
I use about 8mg throughout an entire day. My first shot for the day will be 4mg. Throughout the day, I will do two more shots of 2mg each.
You also have to consider how much diphenhydramine you will be using. Since I do three shots a day, I can use 50mg per shot, totaling out to 150mg per day. If you plan on doing 4 or 5 shots a day, you need to take that into consideration, because if you use 50mg of diphenhydramine per shot, youll be using 200mg – 250mg per day. When you get that high in dosage, anticholinergic effects begin to take hold, causing delirium.
After preparing the antihistamine, how do I add the bupe to it?
As stated above, the best way to do this would be to prepare a solution of antihistamine only then in a separate spoon or cup, crush the buprenorphine up. Add the solution of antihistamine to it, stir, filter, and draw up.
My solution is still really cloudy, what does this mean?
Its suggested to use micron filters when preparing pills for IV. Some people don’t have access to micron filters, but coffee filters would be the next best thing. All you have to do is load an empty syringe with stacked pieces of the filter which have been cut to the diameter of the syringe. Then, you just squirt the liquid through the filters multiple times. Q-tip cotton will also work, but I suggest to not use them unless you absolutley have to. Cigarette filters should not be used. Due to all the other fillers in most antihistamines, you will end up with a cloudy solution after you first draw it up. It is highly suggested to filter this solution multiple times before adding the buprenorphine to it. Filter it until you have an almost clear solution. You wont be able to get it crystal clear, but get it as close as possible. ALWAYS USE A MICRON FILTER IF YOU HAVE ACCESS TO THEM. edit thanks to phrozen
Im using suboxone, and my solution is still really orange, what does this mean?
Suboxone is different than Subutex because it will leave you with an orange solution. It looks nasty, but there is a way to tell if you’ve gotten a good proportion of particulate out of solution. Even though its orange, you can still get it to a point where it will be clear. Youll be able to tell when its there by holding the needle up, numbers facing away from you, and if you can read the numbers on the opposite side, then that’s a good way to tell if you’ve gotten most of the particulate out. Remember, this is not a fool proof way to tell if it doesn’t have particulate matter in it. Its just a way to gauge how well its been filtered. The same suggestions for filtering the diphenhydramine apply here also. ALWAYS USE A MICRON FILTER IF YOU HAVE ACCESS TO THEM. edit thanks to phrozen
So my solution is ready to be injected, are there any extra precautions I should take?
Injecting this solution is more dangerous than injecting a drug like heroin or cocaine. What can come from a missed shot could be disastrous. Be sure you wont be distracted and that you can take your time when injecting so that you don’t miss.
When I injected the solution, it burned really bad. Does this mean I missed?
No. Antihistamines burn when injected. You can use this to your advantage.
I think I may have shot into an artery, how can I know for sure?
This is how you can use the burn from antihistamines to your advantage. Veins flow up the arm, towards your heart, while arteries carry blood towards your hands. If you feel the burn moving up your arm, towards your shoulder, you were in a vein. If you feel it move down your forearm towards your hand, you hit an artery. Also, if shot into an artery, it will be extremely painful. Your hand will begin to swell, and most times go numb.
Besides obvious health risk from IV drug usage, what extra health risks do I have to worry about when injecting these specific drugs?
Some fillers and binders in Subutex and Suboxone are known to be vesicants. Vesicants cause damage to the veins from the inside out. Arterial shots of Subutex and Suboxone have also been known to cause infections resulting in gangrene and ultimately amputation of the arms or hands. Missed shots carry the same risks as missed shots of any other pill, such as abscess and possibly gangrene resulting in amputation if not treated. If you feel you have missed a shot or shot into an artery, seek medical attention immediately.
Is the duration effected by using buprenorphine IV?
Yes. Due to different rates of absorption, the duration will be effected. Anecdotal reports suggest the duration is around 8 – 12 hours, compared to 18 – 24 with intranasal administration, and 24 – 36 with sublingual administration. Take this into consideration before going through with this. It is quite possible to run through a supply of buprenorphine before being able to get a refill due to over usage of the drug. If you are on maintenance and depend on your buprenorphine, please think extra hard before doing this. Make sure you will be able to ration your supply so you aren’t left without any way too early.
Is this a good way to use buprenorphine when speciffically trying to maintain a habit or is should this only be done when trying to get high?
If you are maintaining a habit, the best advice would be to use the drug as directed. There is nothing worse than running out of your drug before you are able to get a refill. If you feel you are at a point in your maintenance that you can afford to spare a pill or two to get high every once in a while, then this is exactly what combining antihistamines and buprenorphine is good for.
If you aren’t opiate dependent, please consider your tolerance before trying to IV these drugs. Buprenorphine is a very potent drug and could cause an opiate naïve user to overdose. Also consider how long ago you have last used a full agonist such as heroin or oxycodone before using IV buprenorphine. If you are opiate dependent but not on maintenance, IVing buprenorphine within 36 hours of your last dose of the full agonist will cause precipitated withdrawals.
Can antihistamines be IVed with other opiates?
Absolutely. Any opiate that can be IVed on its own can be IVed with antihistamines added to it with great results. The same suggestion applies still: Do not exceed 150mg in a day
Last edited:
