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Misc It's time for the West to recognize nux vomica as a legal high  strychnine

red22

Bluelighter
Joined
Nov 23, 2009
Messages
2,169
"The seed is very bitter and highly poisonous but some people get addicted to it and tolerate the lethal dose."[ 1 ]

"Strychnine was once extremely popular as a stimulant. If it wasn't so easy to OD on it, it would still be popular. The downside is its potency. It's just way too potent. You can feel 100 micrograms of it."[ 2 ]

I have experience with both plain nux vomica extract and, most recently, with detoxicated extract. Both have a very healthy feel. And, unlike a lot of things, they're dirt cheap. This is what I mean by "detoxicated":

"Due to the high toxicity, the seeds of Strychnos nux-vomica must be processed before clinical practice. During processing, the toxic alkaloids are converted into their isoforms or nitrogen oxidation derivatives, which are more or equally as potent and less toxic than their parent alkaloids [35,36]."[ 3 ]

The detoxicated version, contrary to the plain version, actually feels a bit sedating, and indeed, one experiment showed that detoxicated nux vomica had an anti-convulsant effect, the complete opposite of the convulsant effect that is attributed to strychnine:

"The seeds processed in milk showed the lowest strychnine content in the cotyledons and exhibited marked inhibition of pentylenetetrazole (PTZ)-induced seizures induced convulsions and maximal potentiation of hypnosis, and were found to be more safe.(76)"[ 4 ]


It's so cool that you can obtain such a cool effect for so cheap—and legally. People should order some "shudh kuchla churna" immediately! That's "purified" "nux vomica" "powder". But one of my products still must have had a substantial amount of strychnine, ie., not all of it converted, because I got a too-strong reaction, ie., a much larger amount of another brand did not give me that reaction, so always be careful with this shit. Also be warned about re-dosing because it took this shit quite a while to absorb. I'm actually kind of disgusted with myself because I was thinking about re-dosing with a large amount out of frustration but my better judgement kicked in and said "this is strychnine, man!" And it kicked in too strong shortly after that!


"It would seem bizarre that a drug such as strychnine, so entrenched in the mind as a deadly poison, would ever be seen as a tonic and pick-me-up, yet that is precisely how it was viewed until the beginning of the twentieth century. The title character, Dr. Griffin, in H. G. Wells’s novel The Invisible Man, “found strychnine to be immensely beneficial,” as Wells writes: “Griffin had a little breakdown. He started to have nightmares and was no longer interested in his work. But he took some strychnine and felt energized."

"The benefits of strychnine seemed endless: Psychologist Karl Lashley found that strychnine enhanced the ability of rats to learn their way around mazes; it helped marathoner Thomas Hicks achieve Olympic Gold in 1904; medical students used strychnine as a pick-me-up while studying for examinations; and even Adolf Hitler was reputed to have taken a strychnine tonic after the loss of German soldiers during the Battle of Stalingrad."[ 5 ]


"I loved lsd as a stimulant so much that I probably wouldve continued using it if I hadn't found out that strychnine is also a stimulant, and its effects are extremely similar to a non-hallucinogenic dose of acid."[ 6 ]

"Its my favorite stimulant (which is fascinating bc im not even really a huge fan of stimulants to begin with), it's my favorite nootropic, and it works wonders as far as the potentiation of psychedelics."[ 7 ]


"Strychnine is one of my favorite medicinal substances. From the moment I obtained authorization to purchase and use strychnine, I immediately did so. I consider strychnine nitrate, pure strychnine, and Strychnos seeds to be highly valuable, though unfortunately they are rarely used today, unlike in the past when their application was widespread."[ 8 ]


1. Rasayana: Ayurvedic Herbs for Longevity and Rejuvenation. H. S. Puri. 2002. Taylor & Francis. 9780203216569. 31. Kuchla (Strychnos nux vomica)

2. 69Ron  2010-01-31 https://drugs-forum.com/posts/757000

3. Important poisonous plants in tibetan ethnomedicine. Ma, L., Gu, R., Tang, L., Chen, Z. E., Di, R., & Long, C. 2015. Toxins, 7(1), 138–155. DOI: 10.3390/toxins7010138
3.2. Alkaloids in Strychnos nux-vomica

4. A review on medicinal uses, analytical techniques and pharmacological activities of Strychnos nux-vomica Linn.: A concise report. 2017. Patel, K., Laloo, D., Singh, G. K., Gadewar, M., Patel, D. K. Chinese Journal of Integrative Medicine. Advance online publication. DOI: 10.1007/s11655-016-2514-1
Detoxification Process of SNV, page 6

5. Neil Bradbury. 2022. A Taste for Poison: Eleven Deadly Molecules and the Killers Who Used Them Part 1: Biomolecules of Death § Chapter 3. Strychnine and the Lambeth Poisoner

6. @Viṣakaṇṭha 2013-11-23 https://www.bluelight.org/community/posts/11972780

7. @Viṣakaṇṭha 2013-11-23 https://www.bluelight.org/community/posts/11973074

8. Dr. Henryk Różański. [Strychnine – Strychninum and Strychnos in Medicine]. 2010-12-31. [Ancient and Modern Medicine] [blog]
Translated from Polish

Original titles:

Strychnina – Strychninum i kulczyba – Strychnos w medycynie

Medycyna dawna i współczesna


Further reading

Strychnine's association with peyote and LSD

Strychnine derivatives as muscle relaxers
 
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Welp, that is all certainly news to me. Can't say I'm too eager to jump at the chance to try "detoxicated" strychnine...
 
Can't say I'm too eager to jump at the chance to try "detoxicated" strychnine...

It's important to point out that properly detoxicated nux vomica only contains a trace amount of strychnine:

"treatment of seeds with the official method (Sample C) decreased the alkaloidal contents by 97% when compared with the [total alkaloid content] of crude nux vomica."

Kumar, A., Sinha, B. N. 2009. Ayurvedic processings of nux-vomica: Qualitative and quantitative determination of total alkaloidal contents and relative toxicity. Malaysian Journal of Pharmaceutical Sciences, 7(2), 83-98.
RESULTS AND DISCUSSION, page 90
 
Why would you want to consume rat poison? They used this shit in hot shots back in the day to kill junkies. Johnny Thunders died that way i believe
 
Why would you want to consume rat poison?

Someone on The Shroomery incessantly posts about the same idea. I just responded to him about an hour ago, so I'll just paste that response here:


I don't think there's any evidence that it's inherently toxic (a la mercury nitrate). It's just that the stimulation quickly turns into convulsions (ie., with a dose increase). Caffeine overdose has caused death too, it's just that caffeine's overdose threshold is much higher.

More importantly, detoxicated nux vomica only contains a trace amount of strychnine:

"treatment of seeds with the official method (Sample C) decreased the alkaloidal contents by 97% when compared with the [total alkaloid content] of crude nux vomica."

Kumar, A., Sinha, B. N. 2009. Ayurvedic processings of nux-vomica: Qualitative and quantitative determination of total alkaloidal contents and relative toxicity. Malaysian Journal of Pharmaceutical Sciences, 7(2), 83-98.
RESULTS AND DISCUSSION, page 90

As I showed in post #29634696, detoxicated nux vomica was found to be hypnotic and anti-convulsant, the complete opposite of strychnine's convulsant effect:

"The seeds processed in milk showed the lowest strychnine content in the cotyledons and exhibited marked inhibition of pentylenetetrazole (PTZ)-induced seizures induced convulsions and maximal potentiation of hypnosis, and were found to be more safe.(76)"

A review on medicinal uses, analytical techniques and pharmacological activities of Strychnos nux-vomica Linn.: A concise report. 2017. Patel, K., Laloo, D., Singh, G. K., Gadewar, M., Patel, D. K. Chinese Journal of Integrative Medicine. Advance online publication. DOI: 10.1007/s11655-016-2514-1
Detoxification Process of SNV, page 6

76. Katiyar C, Kumar A, Bhattacharya SK, Singh RS. Ayurvedic processed seeds of nux-vomica : neuropharmacological and chemical evaluation. Fitoterapia 2010;81:190-195.
 
Someone on The Shroomery incessantly posts about the same idea. I just responded to him about an hour ago, so I'll just paste that response here:


I don't think there's any evidence that it's inherently toxic (a la mercury nitrate). It's just that the stimulation quickly turns into convulsions (ie., with a dose increase). Caffeine overdose has caused death too, it's just that caffeine's overdose threshold is much higher.

More importantly, detoxicated nux vomica only contains a trace amount of strychnine:

"treatment of seeds with the official method (Sample C) decreased the alkaloidal contents by 97% when compared with the [total alkaloid content] of crude nux vomica."

Kumar, A., Sinha, B. N. 2009. Ayurvedic processings of nux-vomica: Qualitative and quantitative determination of total alkaloidal contents and relative toxicity. Malaysian Journal of Pharmaceutical Sciences, 7(2), 83-98.
RESULTS AND DISCUSSION, page 90

As I showed in post #29634696, detoxicated nux vomica was found to be hypnotic and anti-convulsant, the complete opposite of strychnine's convulsant effect:

"The seeds processed in milk showed the lowest strychnine content in the cotyledons and exhibited marked inhibition of pentylenetetrazole (PTZ)-induced seizures induced convulsions and maximal potentiation of hypnosis, and were found to be more safe.(76)"

A review on medicinal uses, analytical techniques and pharmacological activities of Strychnos nux-vomica Linn.: A concise report. 2017. Patel, K., Laloo, D., Singh, G. K., Gadewar, M., Patel, D. K. Chinese Journal of Integrative Medicine. Advance online publication. DOI: 10.1007/s11655-016-2514-1
Detoxification Process of SNV, page 6

76. Katiyar C, Kumar A, Bhattacharya SK, Singh RS. Ayurvedic processed seeds of nux-vomica : neuropharmacological and chemical evaluation. Fitoterapia 2010;81:190-195.


It's wrong to compare it to caffiene or for that matter coke or amphetamine either. Coke, caffiene and speed are all stimulants that oly cause convulsions in overdose. Strychnine's primary effect however is convulsions and by all accounts unpleasant stimulating. It's also a potent neurotoxin

I think ill just stick to good ol ritalin
 
What a disgusting idea shame on the person who made this thread. Lol. This is harm reduction that chemical drug whatever you want to call it should be a poison control chemical
 
It's a sympathomimetic that works primarily on the peripheral nervous system as an Acetylcholine antagonist.

So basically it will stimulate the nerves that power your muscles.

I would expect it to be a rather unpleasant stimulant...

The reason Caffeine, Cathinone and Ephedrine are preferred as stimulants from plants, is that they work on the central nervous system, promoting wakefulness and euphoria, with some milder affects on the heart.
 
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