• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

Is there significant MAO inhibition with 2c-b/d?

QuasiModo

QuasiModo

Bluelighter
Joined
Mar 6, 2008
Messages
742
Location
CA
Can't seem to find any real solid info on this one. Many people in trip reports who infer there "must be" MAO inhibiton but I can't really trust people trying to diagnose which portions of their brains are being stimulated can I?

Thank you to any and all responses.
 
Are you asking if 2C-B/2C-D is a MAOI? AFAIK they are not but I could be wrong. I don't think it's a good idea to take 2C-B with an MAOI but again, I don't really know for sure.
 
there have been reports that selegiline or other MAO inhibitor can intensely potentiate and prolong the effects of 2C-X, therefore there must be some metabolism of the 2C compound by the MAO enzyme. Thus, while the MAO is busy chewing up a 2C-molecule, it is 'occupied' and cannot chew up a molecule of serotonin or dopamine or whatever else is floating around in your brain. Such "competitive inhibition" is usually quite negligible in the case of asking the question "is it dangerous when combined with an SSRI drug?"

then again, 2C-X metabolism is only partly via MAO-- if i recall correctly, major human metabolites are O-desmethyl compounds that are unchanged at the amine end of the molecule. so even the competitive inhibition might be quite minor.
 
THANK YOU! Been trying to find out if I can trip while taking an SSRE (selective seretonin reuptake ENHANCER). WIN!

EDIT:Waita minute, before I get all excited do you have any citations?
 
Last edited:
nope, but you can search here for any threads on deprenyl or selegiline.

according to wiki (citation #11 on the 2c-b page)
2C-B has been shown to be metabolized by liver hepatocytes resulting in deamination and demethylation that produces several products. Oxidative deamination results in the 2-(4-bromo-2,5-dimethoxyphenyl)-ethanol (BDMPE) and 4-bromo-2,5-dimethoxyphenylacetic acid (BDMPAA) metabolites. Additionally, 4-bromo-2,5-dimethoxybenzoic acid (BDMBA) can be produced also by oxidative deamination. Further metabolism of BDMPE and BDMPAA may occur by demethylation. Alternatively, the later metabolites can be generated by demethylation of 2C-B followed by oxidative deamination.
Click to expand...

so actually it looks like oxidative deamination (like that performed by MAO) is the primary route, with some side stops at the desmethyl versions.
 
You must log in or register to reply here.
Top