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Is Rauwolscine (similir to yohimbine) safe to take with mdma

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heerutosen

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Sep 18, 2011
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I read this on pubmed: alpha 2-adrenergic receptor antagonist rauwolscine may function as an agonist at the serotonin1A (5-HT1A) receptor expressed in human brain

I have no idea what this means, but is it safe to take with mdma?
The ingredient is found in a fatburner together with the ingredient higenamine.

Please help
 
if taken at the same time, it looks like it would dull down some of the psychedelic aspects of mdma (5-ht2a antagonism), maybe increase the subjective empathy (5-ht1a agonist). the rauwolscine acts as an alpha-adrenergic antagonist and the higenamine acts as a beta-adrenergic antagonist so it also may reduce the vasoconstriction during the roll. it doesnt look too dangerous to mix with a normal dose of mdma (100-150mg), but you said its part of a fat burning supplement, so be careful if theres any caffeine present in that supplement, and stay hydrated
 
THANX! I took caffeine today at 3PM and my last dose of the fatburner at 4PM. Im planning to roll around midnight.
Probably around 180mg single dose. Thanx for checking this out. I was worried since it is similar to yohimbine wich has mild maoi property according to some sites
 
I dropped half at 00.10 and my last half at 13.10. Shot up at 13.50 and had the best roll this year.. I was insanely energetic (thought somebody might have spiked my drink) and peaked hard for 2 hours during Hardwells best set of the year.
After reading about yohimbe and MDMA i decided to start slow and see how i would react and aside from some nerves everything went fine..
Thanx for responding.

You too Folley, too bad i just read your message, but in retrospect im glad i rolled. You are right tho. Better safe than sorry

Thanx again
 
^ also i dropped 8 hours after using the supplement which i read has a pretty short halflife.
So that factored in to my decision
 
heerutosen said:
I see it also contains 3,3'-diiodo-l-thyronine, but i cant find anything on this ingredient
Click to expand...

this is a thyroid hormone analogue, with only one iodine on the interior phenyl ring instead of 2, it increases your heart rate and blood pressure, increase the metabolization of fatty acids and fatty tissue. with this thrown into the mix, rolling and dancing a lot could be hell for your kidneys and heart, as if the mdma wasnt bad enough on its own. it increases serotonin and downregulates serotonin receptors (in a rats brain at least). so you may want to wait 3 days at least. a week would be best. the more stuff that gets thrown into the mix the more unpredictable it becomes
 
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