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  • BDD Moderators: Keif’ Richards

Is it safe to dose Trazodone with what I've already taken ?

hatrix

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Dec 10, 2011
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Now I tried reading as much as I could find as far as trazodones interactions with stimulants. Seems as though mixing with something like MDMA which has high serotonin activity could be potentially dangerous.

I know that trazodone is NOT an SSRI however, contradictory to what a lot of people for some reason believe, though it IS an antidepressant. However, it is an SARI (selective serotonin antagonist and reuptake inhibitor) so it still has some 5-HT activity, but apparently it's rather minimal.

I also read it has some activity on dopamine, though I'm not certain that's true ?

Anyways, I plugged 60mg of Adderall XR around 8 hours ago. Over that period of time, I have ingested 4mg of Klonopin and 0.5mg of Xanax. Seems my benzo tolerance has grown more than I though, as I don't THINK I'm that intoxicated benzo wise. I can walk about fine and don't feel super heavy.

I'm not to sure if I can get to sleep easily even with all the benzos I've taken. My HR is still elevated near stimulant like levels, though not beating as hard anymore. I really don't want to take more klonopin, I want my script to last and not be half gone from a single nights use.

I'm prescribed 50mg trazodone for occasional insomnia. I've read a few threads saying people took it on adderall comedowns without any problems. I just want to make sure though, as I could only find like 5 threads or so talking about the combo, unfortunately. I know adderall pretty much strictly acts on dopamine, and I've read that trazodone does down-regulate the beta-adrenergic receptors. That would leave me to believe it would stop any of the restlessness I have and knock me out like I want. It's 6:15 AM here, and I want to sleep soon. Very soon. But I don't want to be paranoid about taking the trazodone without first asking if it's completely safe.
 
Your biggest worry would be serotonin syndrome which trazodone can cause, especially if ingested while a stimulant is active. Nonetheless, a lot of the time these combinations are prescribed, your trazodone dose is low, and you've ingested benzodiazepines which inhibit serotonergic and adrenergic activity. I don't think you should have any problems. Best to wait for more advice though, as someone could have a different view.
 
I was fine taking 50mgs, thanks for the info anyways guys. I did a little more reading as far as adderall and trazodone combos and the consensus seemed to be it's perfectly safe and there are minimal interactions.

Only thing I was slightly worried about was CNS depression but it was minimal.
 
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