• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

is it possible to prevent stimulants induced decrease in appetite?

I don't know about guanfacine, but I used to be on clonidine, and that was the best thing I ever tried, I'm autistic, and about the one and only bad point about it, is I tend to get battered by an influx of unmodulated sensory input, and it results in a physical hyperstimulation, and extreme hypersensitivity to stimulants (a bump of coke will have me as high as a line seems to get most of my friends, and two lines will have me going for a nice 3 hours, but I CANNOT take adrenergic stimulants of any kind)

It almost completely killed that, when I used to be on it a couple of years ago, worked even as well as opiates or benzos for it, although its not something that will get you high, and my problem there has more or less no psychological component to it, I don't think, its also very pleasant when filtered up and shot with an opiate+promethazine, or even just booted/plugged/railed on its own.

Next time I see my doctor, I am thinking I'l get back on it, I only stopped because when I spent time inside, a couple of years ago they took great delight in medically unsound fucking with my damn meds.
 
About the original question:
I would recommend cannabis, too. If I read it correctly, you are taking ADHD-medications, so we're not talking about an amphe-binge or anything alike. So I wouldn't expect serious problems with anxiety or panic-induction.

Smoke a small joint around 30 min before the meal and you should be quite hungry. The appetite-inducing effect is something for which I NEVER developed any tolerance. So this might be the answer. It's also far easier to get than the more "esoterical" suggestion in this thread (Cannabis vs. Mirtazapin for example).

Peace! Murphy
 
CB1 agonism does have knock-on negative effects on GABA release, so it can be quite anxiogenic at times, I often feel quite stimulated while smoking and it isn't always pleasant.
 
I personally don't advise smoking weed to increase appetite, due to the fact that it increases heart rate and blood pressure.

My advice is to eat a large amount of calories, fats, carbs and proteins before your first dose and take a good multi-vitamin. If you're on XRs, consider taking IRs 2 or 3 times a day instead. You might find that if you time it right, you'll be able to fit in an adequate amount of food between doses. Personally I never got the whole timing/dosing thing just right to be able to do this, but it works for some people.

Or you could just end up like me and be 5'8" and 100 lbs. It's great fun.
 
^^^
yes im in the same boat, 6'1 and 115 lbs.8o

CB agonists are not a long term solution for most people who have to do intellectual work during the day. my problem with stimulants is not so much an inability to eat but i literally forget to eat the entire day. if i have friends around with normal meal schedules to remind me about breakfast, lunch, and dinner i can usually consume an appropriate amount of food. i am switching to d-methylphenidate ER this week and i hope it will be better than d,l-methylphenidate.
 
MeDieViL said:
i really hate this side effect, especially now i want to start bodybuilding and my adhd meds really interfer with that
Click to expand...


well if you are honestly not abusing your stimulant medication used for ADHD, that side effect of appetite suppression should disppear within a week or so...in my experience....why not work out, then eat, or eat a meal, work out...and THEN take ur ADHD medication? i would assume if you work out at night time the peak effect of your medication should be pretty worn off it is time release medication..if it is instant release-more the better! you can only go so long without eating anyway! like the other people said, take vitamins,drink shakes, and i sure u can manage to scarf down a meal replacement bar,..i know its hard to eat on stimulants....but i think u can handle that
 
if ur on a serious work-out plan, i wouldnt consider trying to take other drugs fix this problem or talk to that doctor bout this medication to help with appetite, etc....decrease ur ADHD dose...see if ur body gets used to it..or if body building is more important, drop the ADHD meds.
 
....the new input made me think about it again:
I agree that the appetite suppression should fade away after one-two weeks if you don't abuse your medication but take it strictly for your ADHD-treatment.

Also, I remember to have heard that increased, regular physical body-work will decrease your ADHD-symptoms as well. At least in some patients a work-out plan helped a lot in this way. So maybe when you started the bodybuilding-exercises you will also be able to reduce a little bit your medication, thus resulting in less appetite reduction.

Just my first thoughts after getting up this morning...

Peace! Murphy
 
Actually, my impression is that tolerance to appetite does fade with time, but there doesn't seem to always be a total disappearance of the effect. I personally may be skewed due to adjunct memantine, but I have read the accounts of many who had appetite suppression persisting many months in at a stable dosing regimen.

OK, so another idea might be supplementing an extract of ginger, or just the root. In folk medicine it (besides the more famous effect of reducing nausea) is supposed to stimulate appetite.

http://www.ncbi.nlm.nih.gov/pubmed/16364290 <-- apparently gingerols are 5HT3 antagonists.

(The 5HT3 receptors positively modulate CCK secretion, which decreases appetite (and interestingly, has also been associated with pain, and with the development of tolerance to opioids))

So 5HT3 antagonism = definitely antiemetic, possibly pro-appetite, and the folk reputation of ginger for doing so is definitely encouraging.

Some people seem to find ginger stimulating, though, so watch for amplified anxiety with the amphetamine, not sure if this would be an issue.

Mirtazapine, btw, is also a 5HT3 antagonist and perhaps this contributes to appetite improvement. Cyproheptadine is an antagonist at 5HT1 and 5HT2, affinities which may or may not directly stimulate appetite on their own, or perhaps its special property of appetite improvement compared to more "classic" OTC antihistamines (benadryl, for instance) which lack said property, could functionally just be the result of H1 antagonism while lacking diphenhydramine/chlorpheniramine etc.'s serotonergic effect.
 
Last edited:
Mirtazapine, btw, is also a 5HT3 antagonist and perhaps this contributes to appetite improvement. Cyproheptadine is an antagonist at 5HT1 and 5HT2, affinities which may or may not directly stimulate appetite on their own, or perhaps its special property of appetite improvement compared to more "classic" OTC antihistamines (benadryl, for instance) which lack said property, could functionally just be the result of H1 antagonism while lacking diphenhydramine/chlorpheniramine etc.'s serotonergic effect.
Click to expand...

1. Mirtazapine is also an anti-histamine at H1.
2. I've tried mirtazapine + stimulants in vivo, and it didn't make a difference.

ebola
 
I used to use an antihistamine called Ketotifen daily with my d-amph; which successfully raised my appetite to an acceptable level. Ketotifen is really hard to find, and isn't available in the states -- but can be picked up easily through mail-order from Canada. It would definitely get me through the day, helping me eat a reasonable amount; until I would go home and smoke myself silly with cannabis which would REALLY kick my appetite into gear. =D (admittedly not the healthiest regimen) But definitely give ketotifen a try if you can get it. Its one of the best antihistamines for increasing appetite.
 
1. Mirtazapine is also an anti-histamine at H1.
Click to expand...

Aye, indeed, so is cyproheptadine. :P

2. I've tried mirtazapine + stimulants in vivo, and it didn't make a difference.
Click to expand...

Periactin definitely improves my appetite with d-amp, but as I said it is sedating, so I would like to find better options.

But definitely give ketotifen a try if you can get it. Its one of the best antihistamines for increasing appetite.
Click to expand...

Cool. Did you notice any sedation/cognitive impairment?


edit: It's 9/16/09 and I didn't want to bump this, but in response to the below cyproheptadine is an OTC antihistamine of choice in Canada and many other countries.
 
Last edited:
Actually, my impression is that tolerance to appetite does fade with time, but there doesn't seem to always be a total disappearance of the effect.
Click to expand...

Yeah, that's why they're not very good drugs to use as appetite supressants - they lose their efficiency afer a few weeks

Seeing cyproheptadine mentioned above, it's used for people suffering from anorexia when admited to hospital etc. ; they obviously don't think it prudent to give it to them under non supervised conditions
 
You must log in or register to reply here.
Top