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is it possible to prevent stimulants induced decrease in appetite?

MeDieViL

MeDieViL

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i really hate this side effect, especially now i want to start bodybuilding and my adhd meds really interfer with that
 
Best bet is to eat high calorie protein rich food. Otherwise, smoking herb has always helped me. I've noticed that the appetite suppression side effect has decreased the longer I've been on ritalin. Another friend of mine on Vyvanse drinks shakes cuz thats easier for her to get down rather than solid food in the morning when the effects are the strongest.
 
yesterday ive taken MDPV and i smoked weed on it and even some GHB and no effect on my appetite, maybe a little but this really isnt enough if you want to eat a bodybuilding diet

i was hoping for some med or something that counteracts this
 
unfortunately, meds for this problem are focusing in the OPPOSITE direction. suppressing the hunger and associated levels of hormones, rather than raising them.

i'm sure they've been created, but don't think any pharmaceutical company would want to market it. plus i think any meds that would increase hunger through elevating the hunger hormone levels might mess you up in the long term. sorta like how L-dopa works really good short term, but can rapidly go downhill.
 
Mirtazapine will increase appetite, but I wouldn't suggest it for solely this purpose.

Also, dexmethylphenidate will decrease your appetite significantly less than the amphetamines, but it may not be as efficacious in treating your ADHD.

Otherwise, simply force yourself to drink shakes while on the stimulant....
 
Shakes are a good idea.

Dextroamphetamine > adderall's racemic mix as far as appetite suppression. I actually experienced more appetite suppression from methylphenidate-related drugs than with dexamphetamine.

Also, tolerance to appetite suppression will develop after a few weeks of stable dosing.
 
^ assumably if he is on them for therapeutic reasons he has already used them chronically and whatever tolerance would be apparent..(?)

shakes will only work short-term and likely soon bloating will be incurred and may actually hamper even further digestion and appetite

most all app enhacers are sedating so therein lies the rub
 
negrogesic said:
Mirtazapine will increase appetite, but I wouldn't suggest it for solely this purpose.

Also, dexmethylphenidate will decrease your appetite significantly less than the amphetamines, but it may not be as efficacious in treating your ADHD.

Otherwise, simply force yourself to drink shakes while on the stimulant....
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Mirtazapine is used in cancer patients for this very reason.

It is disputable whether or not Mirtazapine has any effects other than its effects on the histamine receptors. So talk to your doctor about this option... It definately will not hurt you.
 
I wouldn't be so complacent about it nabollocks, I took it briefly, very briefly, in fact, twice, then flushed the lot down the bog, made my muscles spasm and twitch, and caused severe akathisia and dysphoria.

Nasty, horrible, disgusting stuff.
 
^ assumably if he is on them for therapeutic reasons he has already used them chronically and whatever tolerance would be apparent..(?)
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Depends on a number of factors IMO. If I stop taking my daily dexamphetamine for just three or four days, for example, then (along with a pleasurable rush) the adrenaline-related side effects like blood pressure increase and appetite suppression come back.

I can't comment too much from subjective experience, as I have the important additional factor of taking memantine at 30-40mg daily in order to reduce tolerance to the dexamphetamine's early mood/motivational effects, an approach which seems to have been working fairly well so far.

most all app enhacers are sedating so therein lies the rub
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Yeah, I agree.

Guanfacine, which is used alone to reduce hyperactivity (without much effect on attention) in ADHD kids, is supposed to typically cause less sedation than clonidine due to greater selectivity for a2 agonism, and is combined quite often with psychostimulants in children in order to reduce adrenaline-related side effects -- like heart rate/blood pressure increases, sweating, and appetite suppression -- may be interesting to look at. Theoretically, the right dose (a low dose) of guanfacine could curb the appetite suppression without compromising the beneficial/therapeutic effects of the stimulant. If it didn't work well, it would compromise both.

Dextromethamphetamine, btw, which is more central and has a lower ratio of NE:DA release than dextroamphetamine, probably induces less appetite suppression. Although, besides the difficulty in procuring treatment with Desoxyn there is the additional mechanism of neurotoxicity, possibly active at therapeutic dosages, with this which one may or may not be concerned about.

I sure wish Fencamfamine (from hearing f&b rave about it -- the ultimate clean central psychostimulant) was available ...
 
Periactin (cyproheptadine) increases appetite, but yea, is also quite sedating for most people.
 
Yeah, antihistamines are pretty well known for those side effects. Not the best idea if you ask me either, but if you are having real trouble getting something down Mirtazapine works in 2 ways:

1. Appetite increases
2. Settles stomach
3. Has been proven as a sleeping aid

So I guess this is why they trial it in cancer patients. I guess the poor guys that require pain medication for their cancer probably get an extra hit from the pain med + antihistamine as well...
 
^^^It is also a potent 5-HT3 antagonist, so I don't entirely agree with the statement
It is disputable whether or not Mirtazapine has any effects other than its effects on the histamine receptors
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Also, for whatever reason, the side-effects of remeron are most severe during the first two or so weeks of usage, and the dysphoria can be, at times, pronounced. Because it is not simply an antihistamine, mirtazapine probably should not be used (solely) for reducing amphetamine/MPH related appetite loss. This being said, mirtazapine is a good drug, especially for sleep, as tolerance to the antihistaminergic does not seem to occur.
 
^^So does diphenhydramine, but we don't talk about that ;)

I am not saying that Mirtazapine is a drug that should be dealt with lightly. That is why I suggested talking to the doctor about it. :)
 
I prefer Periactin for sleep (5hT2a/c antagonist, antihistamine) for the shorter half-life, and it has been found to improve sleep quality, with a greater proportion of deep sleep -- not sure Mirtazapine shares this or not via 5HT3 antagonism, but I'm pretty sure it's the antiserotonergic/dopaminergic activity in Periactin that is doing this. Compare to diphenhydramine, which is serotonergic and seems to fuck up sleep architecture. I notice little hangover from Periactin. Would not be able to stand mirtazapine's drowsiness during the day if I were using it as a sleep aid.

For appetite suppression I resubmit my suggestion of guanfacine, which may reduce adrenaline-related side effects when adjunct to a psychostimulant.
 
Prolintane (2-(1-pyrrolidino)-1-phenylpentane) is supposedly a stimulant that actially increases appetite. My try with it certainly had no appetite supressing qualities. Good luck getting any out of a doctor though (it may be discontinued)
 
Prolintane (2-(1-pyrrolidino)-1-phenylpentane) is supposedly a stimulant that actially increases appetite. My try with it certainly had no appetite supressing qualities. Good luck getting any out of a doctor though (it may be discontinued)
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Ohh, sounds pretty juicy.

I would really like an opportunity to try any of these cleaner psychostimulants as an alternative to my d-amph. What worries me though is that, for the inattentive-ADD individual (like myself), some adrenergic activity -- therefore the side effects that this entails - may be necessary for therapeutic effect.

This has been proposed as a reason for what was seen as a typically lower effectiveness in pure inattention for methylphenidate (which most studies claim to be fairly selective for dopamine reuptake inhibition, although I am familiar with research that claims otherwise), than with amphetamine.

Although, methylphenidate often produces more peripheral side effects than amphetamine. Central/peripheral ratio is certainly an issue.

From reading anecdotal reports of people being treated with Desoxyn, these patients often find that compared to dextroamphetamine or especially Adderall's racemic amphetamine mixture, they feel less of a "locked-in" overfocus, less of a rushed, driven feeling from the drug. Some even became sleepy. And definitely a lower incidence of appetite suppression, blood pressure/heart rate increases, etc. This could certainly be related to the molecule's higher brain penetration and higher ratio of dopamine to noradrenaline release.

f&b, I recall your account of -not- feeling rushed in the line to the post office, while on desoxypipradrol.

Interestingly, of the Desoxyn patients, some prefer the calmer feelings, but some report that they found the driven focus of dexedrine to be more helpful in treating their inattention.

I won't try Desoxyn due to obscene cost and as I mentioned some concerns about the additional possible mechanism of neurotoxicity, but I am thinking about adding low doses of guanfacine as adjunct to my dextroamphetamine to see if I can make the whole shebang smoother/cleaner without compromising focus and attention. Specifically, I relate a tendency towards perseverative behavior and some perceived loss of cognitive flexibility to an "excess" of adrenergic stimulation. If the guanfacine works well, I can have my cake and eat it too. The other possibility for these cognitive symptoms is daily low-dose LSD.
 
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