Is it possible to lose sensitivity to (some, many?) RC's?

[pqmomba8]

No, seriously.

Here's the condensed version. 4-FA being (arguably) the favorite agent, has been researched extensively with very positive results. Here's where it turns weird - the last 4 (!!) 'samples' from different and (very) trusted sources have been 'bunk'. But have they? It certainly looks, smells and feels like 4-FA, there's "something" there, you feel perhaps 1/15 the effects of 4-FA. The sources assure me that these samples are "99%> laboratory tested chemicals." I also have a contact (penpal?) on a relevant forum. He and I "chat" all the time. Anyway, he has obtained the sample from one of the sources and reported "feeling grrovy on 120MG maaaaan".

OK. Logically, I should test this on another RC, right, one says to himself? True. In a couple of days, MDPV materializes in possession of the hapless psychonaut. 12MG nasaly. Typically, this individual has pretty pronounced typical MDPV "fast, fast, fast, but in a good way) effect. This time.....well.....there's DEFINITELY the typical MDPV effect, but it's well, subdued, constrained, whatever. Not the same thing.

So, the question is, can one lose sensitivity to (amph type, I guess) agents? (Which, can, of course, be a blessing in disguise, actually.)

What do you guys think?

(Thinking maybe see if M1 still works....lol.)

 

[sekio]

Yes, you can lose sensitivity to smphetamines, though usually only after prolonged periods of abuse.

"Looking smelling and feeling" is not enough to determine the identity of a substance.

 

[3rd_I_blind]

It would be handy if you included figures on past amphetamine use for the 'hapless [prolific?] psychonaut' you talk about.

 

[pqmomba8]

****It would be handy if you included figures on past amphetamine use for the 'hapless [prolific?] psychonaut' you talk about.
Right. Fair point. The said psychonaught has been researching RC's (almost exclusively apmhs) for about a couple of years. By themselves and in combination of (4-FA, M1, 4MMC, MDAI and [very occasionally] MDVP.) Probably more than one should (though pretty religious with the 'harm reduction' protocol.)
Go through a few days use [with about 5 - 6 hours of sleep each night] of 'tweaking' then lay off for about 1 week. This has been a pretty regular regime for the past 24 months or so. (The insidious nature of these RC's is that they 1. easily available, 2. relatively inexpensive and 3. one can remain completely functional going about your day at work and at home.)

Anyway, these are pure chems - I am almost certain, based on a number of factors. (Long story.)

BTW, he did have one of those "mega" experiences just recently (a bout week or two back) documented here. I believe (though not completely certain) that that was the last 'successful' research.

http://www.bluelight.ru/vb/threads/...ail!-(MDPV-4-FA-M1-MDAI?p=9920459#post9920459

 

[3rd_I_blind]

With two years of rather regular use, tolerance seems an obvious explanation.
But one would of course expect this tolerance to build gradually, upping the dose with a few percentage every few weeks.

So, best advice in my opinion would be to lay off for at least one or two months.
And perhaps ask yourself how you want to continue with your RC use in the future.
You might not agree with me, but I do not think you can go on with this for very much longer.

 

[pqmomba8]

With two years of rather regular use, tolerance seems an obvious explanation.
But one would of course expect this tolerance to build gradually, upping the dose with a few percentage every few weeks.

So, best advice in my opinion would be to lay off for at least one or two months.
And perhaps ask yourself how you want to continue with your RC use in the future.
You might not agree with me, but I do not think you can go on with this for very much longer.

I do agree, the use has been excessive and shame on the user and all that, however, I could not find ANY research evidence that specific receptors would completely (and SUDDENLY) stop working and believe me I googled the sh*t out of that particular subject matter. To make it even more mysterious (and as you allude in your reply), tolerance (gradual) would be a factor, however, with a few exceptions, this individual have been keeping pretty much the same consistent dosage for the RC's in question for the entire duration of use. (Really.) It's just weird....and sad.....but probably for the best. Anyway, at this point, it's just curiosity / interest - if anyone knows something about this stuff, please point me to it. Muchos gracias.

 

[pqmomba8]

Done. Finito. Caput. Konets.......... The individual did 250MG of M1 (verified from previous uses as legit) and did not feel a thing. Then, next day, combined 125MG of M1 and 15MG of MDPV - nada, zilch. The said individuals is waving "bye-bye" to the RC's. It was fun........

I just hope that this is the ONLY impact and did not mess anything important / vital up. Ugggghhhhh.

TC.

 

[3rd_I_blind]

I just hope that this is the ONLY impact and did not mess anything important / vital up.

Just quit your worrying, a lot of 'drug-induced emotional problems' are primarily caused by excessive worrying and finding 'evidence' in everyday shit.
Sad to hear the RCs have lost their magic for you, perhaps this is a good time to look into something a bit more psychedelic?

Dunno if you're into tripping, but it might at least be worth a shot.

 

[pqmomba8]

>>>>Sad to hear the RCs have lost their magic for you, perhaps this is a good time to look into something a bit more psychedelic?
LOL. I was just thinking that. The individual has done some hallucinogens (waaaaay) back in the day [LSD, Mushrooms], but while enjoyable, always found it a bit too intense and um, well, 'inwardly retrospective' and he really doesn't like getting "deep" during these times, just wants to enjoy himself. But he has read about the compounds as such 2C-X, but most of those also seem pretty intense and / or already scheduled by DEA. THAT BEING SAID, I was just reading about 2C-C, "softer, milder, gentler and more euphoric trip." And it seems to be available and UNSCHEDULED. (So far.) Hmmmmmmm.

Thanks for your input and feedback. BTW, where in Holland do you live? I LOVE your country. Been traveling there on regular basis for the past 20 years using "going to visit my brother", who lives in Den Haague as an excuse, lol.

 

[PhyllipThylamine]

This is an interesting story! I find it quite unusual that things should ALL suddenly stop working all at once! I have to wonder if perhaps the OP is, within him/herself, aware that use of stimulants with such regularity is unhealthy & has subconciously "turned off" the susceptible parts of his/her brain. If the poster does have any misgivings about using these substances, this is about the only possible explanation, though unlikely.

Suggesting the use of Psychedelics as a replacement isnt such a bad idea. I often alternate my use of compounds between stims, entactogens & psychedelics & (except with drone), I havent noticed any decrease in intensity or duration of the effects of chemicals such as MDPV, M1, 4-FA. I did notice that, after using 4-fa four days in a row, that I suffered a decrease in pleasurable effects & an increase in hangover duration & intensity. I thought at first that 4-FA was the "new Ecstacy" with absolutely no hangover, but I see that with regular, ill-spaced use brings about the same less than pleasant after-effects as the other stims noted above as well as genuine MDMA, cocaine & speed.

Mephedrone kinda got a wee grip on me last year & I found myself using it more nights per week than not. The main health effects of this activity were primarilly mental & psychological & appeared only after some weeks of regular drone-ing & with the gradually increasing doses. Knocking this on the head after realising my problem returned me to my usual stablity (or perhaps my usual instability, if you know me LOL) with a couple of weeks. Occassional drone seshs still occur & my tolerance to this compound has now returned to pretty close to it's original intensity. The same occured after I began spacing my 4-FA doses to no more than one nights usage (180mg in 3, ever decreasing strengths) every 2 weeks. I am now back to using 4-FA without any obvious negative effects. I feel 4-FA & M1, due to their decreased serotinergic affinity, can perhaps be used a little more often that MDMA without the same after-effects. I might be okay using 4-FA once a fortnight but from experience I can say the using MDMA that regularly would bring me emotional problems (depression, anxiety, over-tired, irritable) within no more than about 2 or 3 months. My use of MDMA, pretty much from the start 20 years ago, has been irregular & I am still capable of feeling the magic.

Anyway, I do go on...

I agree, OP should leave off everything for the sake of health & should tolerance disapear in time, it might be wise to cease daily or even weekly use of compounds & use them only for special occassions. It's easier said that done, especially when in the grip of something enjoyable, but a good long 3 month abstinence should do you the world of good. Try it. In the meantime you can start research & reading on Psychedelics & make plans for when you're back on track.

Best of luck Ph

PS For those such as yourself who may be less comfortable on pshychedelics I suggest you keep your doses at the low end, especially for ALL 2c-xx even 2c-c which CAN be pretty strong. The 4-substituted Tryptamines such as 4-aco-mipt, 4-ho-mipt & 4-ho-met (my favourite) are much more short, subtle & controllable than the 2c-xx chemicals. I recomend these if you wish to trip but you're wary. Once again, good luck

 

[pqmomba8]

Thanks for sharing the stories and all the (very sound) advise. Well, it's been almost two weeks since the aforementioned agents have been used. Feel just fine, nothing outrageous as far as WD's or even cravings go................BUT, I THINK that the "IT" agent has been found.......drum roll please: 5-APB was tried last night while hanging with a few British colleagues / programmers (splendid Java coders, old chap lol.)

LOVE IT!!!!!! Not sure what the dosage was but wow, just wow. Beautiful, warm glow, great mood, music appreciation, happy (not introverted) thoughts, slight color distortions, etc. Beautiful thing man......

 

[effie]

Excellent, glad you have found something you enjoy!

We Brits are always lovely.

Going to close this now but feel free to shoot me a pm if you have any queries.