Is it known how different substitutions of 2c-x affect different parts of the brain?

[pharmakos]

i don't have anything too constructive to add to this, but i will re-emphasize a point that the OP made but no one else has commented on yet... 2C-E and 2C-P are REALLLLY different in effects!

 

[nirvus]

maybe this will shed a lil' light on the situation. I used a model for 5ht2a receptor whose accuracy we are debating in another thread, but for purposes of comparing/contrasting binding modes for tryps and phens, I dunno but they ARE pretty!

Here's 2C-E and mescaline:

 

[nirvus]

And here's mescaline and 5-MeO-DMT:

 

[nirvus]

Ok maybe those will give at least a ballpark idea of how much you might or might not be wasting that hit of mescaline!
Don't take my word for it, I'm not a doctor I just play one on TV. I made these for entertainment and educational purposes only. Have fun / be safe.

nirvus

 

[specialspack]

Also Shulgin discovered that 2-CB (by means of radioactive bromine radio-imaging) found out that the substance accumulated in the lungs before reaching the brain suggesting that the lungs metabolize 2-CB into a different compound before reacing hte CNS.

Actually, it was DOB, not 2C-B:

http://isomerdesign.com/PiHKAL/read.php?domain=pk&id=62

 

[ungelesene_bettlek]

The 2c- series act as broad spectrum serotonin agonists with an additional adrenergic component.

what do you precisely mean by adrenergic component? are they adrenaline releasers or adrenaline receptor agonists? if so, at which adrenaline receptors?