From what I've seen of this drug, it is dangerous by itself. So it would surely be more dangerous whilst under the effects of LSD or 2C-E. However, I'm probably as knowledgeable as you when it comes to this so my opinion is not exactly well-founded. I will say that LSD and 2C-E are both quite stimulating, so a non-stimulating psychedelic (I can't think of any besides maybe DMT) would be preferable.