jacktheripper42
Bluelighter
- Joined
- May 9, 2017
- Messages
- 62
People get these syndromes and anxiety from all sorts of drugs, but when you have billions of people on a planet you can certainly find a mega thread of people having xyz symptoms from whatever drug. If you only see the 25i thread because that's what you were looking for, then you may assume it's something specific to that drug, but that's far from reality.
The thing is that your story is pretty common - the anxiety only really sets in after researching thing.
I talked with a guy who had this after a different drug for a long time (did a drug, was fine for a while, then started reading and got obsessive/anxious) and he went on to fully recover with mindfulness (he ended up going to a mindfulness retreat and practicing mindfulness a lot, with results coming slowly but surely).
He researched a lot and had to be convinced over and over that he hadn't done "permanent damage". Then he started worrying he was doing permanent damage to his serotonin with SSRIs. Trust me, your story is common.
What doesn't help is that people freak out over the "synthetic drug" bit, listen to yourself here for example
"25i NBOMe and its super high potency and full agonism displayed on the 5HT2A receptors."
But cannabis is "natural", yet it can cause intense depersonalization and psychosis in some who are predisposed to it or who have a bad experience on it. Same with feeling off for a while after a bad trip. Or drugs aside, feeling off for a while after a traumatic experience or an emotional loss. No super potent full agonism at 5-HT2A required
Yeah true, it's just cannabis is a weak partial agonist at the cannabinoid receptors and it can't actually cause permanent damage. I just get really worried about the high affinity and high efficacy part at the 5HT2a receptors. The scary part about this entire thing is: 1. 25I came out in 2010, only 7 years of human exposure to it. 2. There are a bunch of negative after effects reported after use, development of anxiety disorders/panic disorders etc. 3. 25I is one of the only few full agonists of the 5HT2A receptors and it has a ki value of .04, which makes it 100 times the potency of LSD on these same receptors, which worries me that some sort of conformation change occurred making it harder for my serotonin to bind. (Dr. Nichols told me its impossible to change the conformation of these receptors, since the proteins that make the receptors are elastic like a rubber-band. A ligand can push down on it and alter its conformation but once it is gone, the receptor goes back to its native conformation).
Now, the reassuring parts of this entire situation are: 1. Dr. Nichols told me that 25i can not damage or change the conformation of receptors. If they're internalized or downgraded, more are made to take their spot 2. I posted on reddit and a bunch of other people talked about how they've done way more 25i and feel completely fine (over 200 doses at 1000 ug etc. [Don't know if these people are being completely honest])3. My friends who've also taken the substance said they feel in control of their mental health, although they do deal with bouts of anxiety (One of my friends who did around the same amount as me actually developed epilepsy recently after seizures that hospitalized him and ever since he's been on the keppra medication, he's said he's felt a lot more control of his life and anxiety - Something interesting to note). Do you think that the 25i had any effect on this? He developed seizures a couple of years after his last trip.
I just have to have faith that I didn't inflict any sort of permanent damage.