Misc Intranasal Pregabalin

[TheTwighlight]

Okay, I know a lot about pregabalin - well, pretty much everything about pregabalin. I realize the high bioavailability of the drug. But one thing I have never been able to get a clear, definitive answer about is whether or not snorting the stuff makes it kick in faster.

Yes, I've searched.

Let's say I'm about to play a show with my band (I'm not) or have a speech for a group of people/class (again, I'm not). Would snorting it make it kick in faster for anxiolytic effect?

I know it doesn't have that effect on everyone, but it does on me, so comments of "well, it may not work as an anxiety drug for you" can be omitted here.

Thanks in advance,
- TheTwighlight

 

[Tommyboy]

I'm not sure about the rate of absorption from sniffing it, but taking it orally on an empty stomach causes it to be rapidly absorbed, so I would go that route.

 

[TheTwighlight]

Yeah, I knew that already, and that's how I've been taking it (scripted for 4 years on and off for FMS, other times Neurontin). I mean, I've snorted the hell out of it back when I was on a lot of drugs, but no longer. Never knew for sure back then. Figured I might pop a few at once and then sniff it to make it kick in faster if that worked (I love the way it feels in high doses). It's strange b/c although it absorbs rapidly, it still takes a couple hours to really start working.

 

[tyrael]

Not that I'm an expert in the drug or anything but it follows the standard ROA's - IV, intra-nasal, and PO.

Again one can't give a definite answer but the BA of most drugs follow the same path, in the three available routes I would say from highest to lower BA - IV, intra-nasal, and PO.

Having said this, and particularly considering the indications, standard bio-variability (from one person to another) can change the effects.

No other medications being use or any co-morbidities?


Sorry, I realise this isn't really a definite answer for you. However going off basic bio - yeah, it should!

 

[DroneLore]

What does the P in PO stand for? I'm assuming the O is for Oral.

 

[InterzoneAgent]

What does the P in PO stand for? I'm assuming the O is for Oral.

P = Per

Per Oral (latin and means "by mouth")

You can insuffilate pregabalin, but i think most agree that it's best to just eat it.

Make sure to take it on empty stomach!! I remeber food slowing the come up quite alot.

The amount of powder to sniff is quite big, depending on dosage of course. Not sure if the amount of powder would be too much to absorb properly from the nasal membranes.

edit. Also dissolving the powder from the capsules to water and drinking that should speed the absorbtion from stomach. I remeber reading about people IV'ng pregabalin succesfully, so if taking orally you can dissolve it for example in a drinkable amount of water to make sure all of it dissolves. + The non-dissolved particles will absorb too anyways. The inactive ingredients will be left suspended in water, but the pregabalin will be dissolved.

 

[THC2LSD]

Insufflated pregabalin works. The first time I tried it, me and some other people snorted the powder in the capsules, thought it suck. Then we drank some beers and got really fucked up. So you can snort it.

 

[darkwarrior21]

I take 75mg of this drug when my nerve in my hand acts up. I have heard it can make you high so i tried it last night. About 8pm, I snorted 25mg and swallowed 300mg. i had eaten some nachos about 30 minutes prior but it wasn't much. Then about 5 minutes later, I snorted another 25mg. An hour later, I snorted another 50mg and started feeling a buzz about 45 minutes later. Took a couple hours to kick in, even with snorting some.

 

[TheTwighlight]

I've actually snorted it plenty of times, but I was so fucked up on other drugs while I was doing it that I couldn't tell what was doing what in the midst of the GABA-fueled madness I like to call "getting high". Mixing benzos, barbs, & GABA analogs all together then trying to tell what effect the insufflated pregabalin has, has been somewhat fruitless thus far.

I can't think today. I'm stopping here.

 

[DexterMeth]

ThouArt, chime in on this.

lol

 

[Vaya]

I was prescribed Lyrica for several years and have experience with most ROA with it... I can say that insufflated pregabalin works; it works more quickly than oral (PO time to reach CMax is ~1.5-2 hours IME; insufflated CMax felt more like 10-25 minutes).

This was irregardless of pill formation/ratio of inert material to pregabalin (i.e. 25mg, 50mg, 100mg, 150mg or 300mg capsules)

The experience could be termed 'dysphoric,' I know some who liked it, but I always enjoyed eating or plugging it and found intranasal to be an experience that, once in the thick of it, I more often than not wished I had avoided. The level of cognitive clouding is too abrupt, persistent and saturated that I could find no use of myself whilst on it. Keep in mind this was purely when I snorted it, though.

Again, I've done this any number of times with virtually no variation; I suggest following others' advice and simply eat it. You'll get a longer, more worthwhile experience with notably less negative side effects.

~ vaya

 

[Transform]

Just to chime in on this, theoretically it should be quite ineffective nasally because of the high lipophilicity of the molecule, in the same way that snorting benzodiazepines is inadvisable.

For ultimate absorbption, I think dissolution in hot water, vodka or olive oil followed by swallowing on an empty stomach would be best.

 

[batrider]

I was on 450 mgs lyrica / day for several years, high doses are just not enjoyable to me and there was a complete trainwreck experience once. I prefer to just eat it. Snorting burns like all hell some of the time (only experienced 150s), the taste is bad, I honestly think there were 0 benefits. I always would imagine the powder was something else too, which may have been why it was always so disappointing...

Just be careful, it's a more powerful drug than you think.