Intranasal absorption enhancers

[FormerBeagle]

Any thoughts on the use of substances to enhance absorption, and perhaps decrease irritation? Intranasal is such a rude ROA imo that there is a lot of room for improvement. I have some dodecyl maltoside (mentioned in the article) on the way to play around with. DDM is used in an intranasal diazepam formulation, used in seizure rescue.

https://mdpi-res.com/d_attachment/pharmaceutics/pharmaceutics-15-02119/article_deploy/pharmaceutics-15-02119.pdf?version=1691653362

 

[FormerBeagle]

In the case of the Dodecyl Mannoside that I have ordered, I believe the mechanism involves loosening tight junctions between cells to allow faster absorption into systemic circulation.

I recall that DDM speeded the rate of absorption up to five times in one study.

Other approaches that I have seen in patents include adding a liquid substance that gels at body temperature. This slows the substance getting washed away by cilia and mucus.

Low concentrations of ethanol supposedly help with penetration, and I almost always include a small fraction of it in sublingual preparations.

 

[realgar]

In the case of the Dodecyl Mannoside

Mannoside or maltoside? As a monosaccharide derivative, dodecyl mannoside has a much lower HLB value than dodecyl maltoside.

 

[Rectify]

If You Are Having Insuffulation Inflamatory Nasal Repercussions, O What A Friend We Have In AFRIN (oxymetazoline) No Drip.

Afrin Has Just A Tiny Bit Of Benzyl Alcohol Mixed In Which Really Is A Nice Touch.