Intolerance to GABA agonists (alcohol, phenibut)

[alex921]

Ever since I used cocaine, and a few times stimulants (ritalin,dexedrine).
I dont respond well to GABA agonists anymore.
In the past I could get always get a drink and feel good when I was drunk. But nowadays, I feel nothing. It just makes me more anxious and very sleepy.
Phenibut makes me me sleepy to.

Can anyone explain? In the past I responded well to alcohol?

I feel like i fucked up something in my brain, also my anxiety has gotten way more severe due stimulants(rit/dex), Ive not used alot though.
And cocaine about 10 grams.

 

[neversickanymore]

Hey alex921 welcome to Blue Light. I'm going to swing this over to BDD and see if the good people there can give you some clues as to whats happening.

TDS ----> BDD

 

[alex921]

Also i want to mention that it seems stimulants induced my anxiet order. I used to drink caffeine just fine, but nowadays I got panic and such... Any advise?

 

[tyrael]

Ever since I used cocaine, and a few times stimulants (ritalin,dexedrine).
I dont respond well to GABA agonists anymore.
In the past I could get always get a drink and feel good when I was drunk. But nowadays, I feel nothing. It just makes me more anxious and very sleepy.
Phenibut makes me me sleepy to.

Can anyone explain? In the past I responded well to alcohol?

I feel like i fucked up something in my brain, also my anxiety has gotten way more severe due stimulants(rit/dex), Ive not used alot though.
And cocaine about 10 grams.

Well, at a guess really could be a number of things....

If one drinks a lot (as in, "alcoholic levels" - not saying you're an alcoholic! ) the body response by increasing the (main) enzyme (alcohol dehydrogenase) which metabolites alcohol (to a non-toxic metabolite). It does this so the body is capable of metabolising greater quantities of alcohol and thus preventing damaging. (this is why, an alcoholic is able to down a full bottle of say vodka and not die of alcohol poisoning since their body is more capable. Opposed to us "normals", which would die of alcohol poisoning. It's a defence mechanism). This is also one reason why if someone doesn't drink for a long time (6 months, 1 year+), they are able to become drunk quite quickly as the reverse happens; the body will reduce the transcription (creation) of this enzyme if it's not being used.

However, you say any GABAergic substance has loss efficiency? (so I don't believe it's what I described above). It does however follow that any damage to GABA receptors can cause symptoms which as anxiety/nervousness/panic attacks/etc.

Off the top of my head I can't think of how (abuse of) cocaine/stimulant use could cause this kind of damage. All I can say atm is maybe it's the end of stimulant drug use for you.

Do you drink when dosing cocaine? Possibly the metabolite cocaethylene?

Hopefully someone else can come up with something else....