• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Heroin Interesting study on opiod injection and endocarditis risk

  • Thread starter Thread starter cj
  • Start date Start date

cj

Bluelight Crew
Joined
Nov 18, 2008
Messages
9,871
Location
Twin cities made of ashes
So I just found a fascinating study on the risk of endocarditis in iv drug users sorted by injection technique and practice. The study shows that alcoholing off your skin and not reusing needles drastically lowers the risk of death from endocarditis. The study goes from age 20 to age 60. Stratified by high risk techniques and high use vs lower risk techniques and high use. It's startling. Simply using alcohol in the injection site and using clean needles lowers your risk drastically. if you iv drugs you need to read this!!! My wife had endo and now has a artificial valve while her first husband died at age 24 from endocarditis. Its a gnarly disease. I can't stress enough how scared iv users should be if endocarditis.https://pmc.ncbi.nlm.nih.gov/articles/PMC8662770/

The probabilities of death from IE by age 60 years for 20-, 30-, and 40-year-old men with high-frequency use with higher infection risk techniques compared to lower risk techniques for IE were 53.8% versus 3.7%, 51.4% versus 3.1%, and 44.5% versus 2.2%, respectively. The predicted population-level attributable fraction of 10-year mortality from IE among all risk groups was 20%. We estimated that approximately 257 800 people are expected to die from IE by 2030.
 
So I just found a fascinating study on the risk of endocarditis in iv drug users sorted by injection technique and practice. The study shows that alcoholing off your skin and not reusing needles drastically lowers the risk of death from endocarditis. The study goes from age 20 to age 60. Stratified by high risk techniques and high use vs lower risk techniques and high use. It's startling. Simply using alcohol in the injection site and using clean needles lowers your risk drastically. if you iv drugs you need to read this!!! My wife had endo and now has a artificial valve while her first husband died at age 24 from endocarditis. Its a gnarly disease. I can't stress enough how scared iv users should be if endocarditis.https://pmc.ncbi.nlm.nih.gov/articles/PMC8662770/

The probabilities of death from IE by age 60 years for 20-, 30-, and 40-year-old men with high-frequency use with higher infection risk techniques compared to lower risk techniques for IE were 53.8% versus 3.7%, 51.4% versus 3.1%, and 44.5% versus 2.2%, respectively. The predicted population-level attributable fraction of 10-year mortality from IE among all risk groups was 20%. We estimated that approximately 257 800 people are expected to die from IE by 2030.
So the difference between high and low risk techniques was only the needles and the alcohol? Or also anything else? (Pls don't blame me for not reading the article 😅)
 
I wish people wouldn't IV drugs period. Although I know we live in reality & people are gonna do it anyway.

But this is great information for harm reduction.
One of my friends just lost their girlfriend from shooting up.

I've been an opioid user for 18 years & I've never injected one. Thought about it, but I thankfully have always had an "Ick" thing with needles going into my veins. I don't even like having to get blood drawn. I have inject stimulants & other drugs though.

It's hard for me to understand. I'm assuming people are just addicted to the needle itself, because the rush really isn't THAT much better than through other less risky routes. I use to snort my heroin & it would come on within 2 minutes or so. I mean if a drug is capable of passing through your mucus membrane, then snorting/smoking is basically going to enter your bloodstream right away anyway, no endocarditis or cardio risks at all, it's just gonna take a slightly little bit more time for it kick in. So I hope people who use needles one day see that other ROA's are just as effective & are much safer. It's worth it, so you can stay alive to do more drugs. lol
 
I wish people wouldn't IV drugs period. Although I know we live in reality & people are gonna do it anyway.

But this is great information for harm reduction.
One of my friends just lost their girlfriend from shooting up.

I've been an opioid user for 18 years & I've never injected one. Thought about it, but I thankfully have always had an "Ick" thing with needles going into my veins. I don't even like having to get blood drawn. I have inject stimulants & other drugs though.

It's hard for me to understand. I'm assuming people are just addicted to the needle itself, because the rush really isn't THAT much better than through other less risky routes. I use to snort my heroin & it would come on within 2 minutes or so. I mean if a drug is capable of passing through your mucus membrane, then snorting/smoking is basically going to enter your bloodstream right away anyway, no endocarditis or cardio risks at all, it's just gonna take a slightly little bit more time for it kick in. So I hope people who use needles one day see that other ROA's are just as effective & are much safer. It's worth it, so you can stay alive to do more drugs. lol
I second most of that but why is there a difference to injecting stimulants? They're way more risky to iv because of the cardiac arrhythmia they can cause... And it's not like I didn't shoot coke when I was young either, but I wouldn't dare it now...
 
I gotta disagree iv heroin is way better then any other roa to me. It's not even close. But then again I've been injecting for 20 years now almost.

My current wife had severe infective endocarditis requiring a prosthetic valve. We've been iv for years now with no reinvention just from very basic sterility
 
I gotta disagree iv heroin is way better then any other roa to me. It's not even close.
Now that's also true 😀... But there are so many complications with it. At least for me... .. not necessarily life-threatening but painful.
 
I second most of that but why is there a difference to injecting stimulants? They're way more risky to iv because of the cardiac arrhythmia they can cause... And it's not like I didn't shoot coke when I was young either, but I wouldn't dare it now...
Oh I didn't mean there was any difference. I just meant I've only ever really injected stimulants. Mostly because I let other people inject me with them. And there was a period after my mom died where I went through a self destructive phase, so I let some one inject me with meth daily for a few weeks.


I gotta disagree iv heroin is way better then any other roa to me. It's not even close. But then again I've been injecting for 20 years now almost.

My current wife had severe infective endocarditis requiring a prosthetic valve. We've been iv for years now with no reinvention just from very basic sterility
I feel like people say this just to justify their IV use. But I've also never injected my heroin, so since I don't know, I could be wrong.
It just doesn't seem worth it to me. I got plenty high snorting my heroin, no IV complications necessary.

There's also plugging. Almost every route except oral is going to enter your bloodstream pretty quickly anyway. If you smoke a drug, it immediately absorbs into your lungs & into your bloodstream. If you snort a drug & it's water soluble & lipophilic, then it's going to go right into the closest blood vessels & penetrate the blood brain barrier.

The only real difference is the time it takes for the drug to reach your brain & it's bioavailability. That's all really. Shooting is usually 100% bioavailability, so I can some what understand it in that regard, for people who don't wanna waste any of their drugs. To say that shooting a drug directly into your vein is so much better/different than snorting it or smoking it just seems absurd to me though. Because other than the length of time for it to kick in, it's all still the same drug & it's all entering your brain & CNS some how, at some point. Snorting goes straight to the blood brain barrier, so even though it'll take an extra minute or so, it's basically going directly into your bloodstream as well. I have a hard time believing that the different ways of putting it directly into your bloodstream would make it a completely different drug.

When I had low tolerance, a small bump of good brown had me nodding & itching anywhere from 4-8hrs. So why bother with injecting if I already get plenty high that way?

I found shooting meth VS smoking meth to be different.. but only at first. After a little while, it all feels the same anyway. I needed less meth when I injected & obviously there's a rush to it. And when smoking it, I needed to smoke a lot of it to get high. But once I got high & the high was going, it honestly all felt subjectively the same to me.

Other than the faster onset, I did not find IV meth to be any more enjoyable than smoking it. Not enough to continue to IV it anyway. The risks outweigh the benefit of just 'faster onset' time. In fact, I found twirling the pipe to be more of an addictive "ritual" than IVing it. Seeing how well you can vaporize it, twirl it & get those dragon hits is a pretty addictive feeling all on it's own.

I think it's possible for people who are already predisposed to liking needles to subjectively feel that it's "better", simply because they get a rush just from injecting. Hell needle users will inject water just for a "placebo" rush. So if you already like shooting up, of course you're gonna find drugs "better" that way than any other way.

Maybe the IV heroin high is subjectively better to some, but it also doesn't seem worth it at all. Not only do you need to worry about bacteria, but unless you're getting pure heroin, then you have no idea what else you might be shooting into your veins. And if whatever it's cut with isn't water soluble, it's just going to clump up in your cardiovascular system & cause problems later down the road. I've heard that the heroin in places in Europe gets cut with milk powder & caffeine. Can't imagine shooting milk powder & caffeine several times a day is going to be very good for you.

I've known 2 people actually that have died from strokes/heart issues after injecting drugs in the past year. So in the spirit of harm reduction, I will have to disagree that shooting heroin is "better" (even if it's true, since I am ignorant to what IV heroin actually feels like) than just snorting it. It's all the same drug, but with snorting you're gonna have to wait an extra minute or two to feel it & you're not gonna get 100% of the drug, but it's better than dying or living with cardiovascular disease. Heroin reaches the brain pretty quickly with snorting anyway, so I just don't get the hype. In fact heroin was made to be able to pass the BBB more quickly than morphine, so shooting it directly into a vein just kinda seems.. redundant.
 
Last edited:
Better was a poor word choice on my part. It's certainly much more dangerous for multiple reasons. Personally shooting is all about the rush. I mainly use for the rush. But your point is well taken. If I had to do it over I would avoid iv drugs.
 
The more I think it over the more I disagree with the snorting is just like shooting. It's not at all comparable. Honestly I'v is dangerous but it is significantly better feeling
 
After Purdue Pharma removed OxyContin from the Canadian market replaced with OP new formula……PF Hydromorph-Contin XR beads 3/6/9/12/18/24/30mg capsules + (Hydromorphone XR - Dilaudid 2/4/8mg IR tablets)

After HM Contin scripts skyrocketed……so did Endocarditis (which I too got) ….pulverizing the XR beads into fine powder, adding 0.7ml clean water (and stupidly adding heat, which melts the waxy excipients) although filtered the HM solution was still contaminated with harmful excipients, wax, insoluble compounds etc

After months of daily IV administration of HM Contin I developed heart issues and chest pain. I called 911 immediately and the bus came, took me to the hospital and was told I had endocarditis (inflammation of the protective sack covering the heart) I was given steroid anti-inflammatory meds Prednisone etc

I read an article that after HM Contin scripts dramatically increased so did the cases of Endocarditis due to people injecting the XR beads containing wax and other insoluble excipients. Why? Because Hydromorphone is an AMAZING Opioid narcotic analgesic, most often administered in hospital settings via IV/IM/SC administration- 100% bioavailability……Dilaudid IR tablets are safer to inject….vintage bottles of Dilaudid say “hypodermic tablets” meaning you can orally take them…or dissolve in sterile water and inject.

Oral Hydromorphone has PATHETIC PISS POOR oral bioavailability of approximately 30%…..nearly 70% of the dose is destroyed via first pass metabolism. Your liver destroys 70% of the oral dose……so, to be smart and get most out of your script, people would rather bang it 100% bioavailability

Safest…..draw up HM Contin solution in oral syringe, lay on bed on side, lightly apply lube or whatever, only insert 1/3 to half length of your pinky finger (area in rectum rich in blood vessels) and slowly push plunger in, warm HM solution enters and leave syringe inside, lay on side for few minutes…..you’ll feel the unmistakable sensation of pleasurable opioid euphoric warmth & comfort. Remove syringe and have toilet paper ready to wipe

Safe and VERY effective

Other than that…..Canadian Sandoz Pharmacuticals has on market a tiny 10ml glass vial containing an astonishing 1,000mg’s of pure Pharma Hydromorphone HCL (100mg / per Ml) absolutely amazing

SANDOZ Pharmaceutical
Hydromorphone HP FORT
10ml glass bottle IV/IM/SC administration
100mg / per Ml
Small red labeled Hydromorphone HP FORT 1,000 mg

I wish I have 500 glass bottles in a cold dark fridge
….and 100kg (220 lbs) drum of pharmaceutical grade API compounding powder of Hydromorphone
 
I wish people wouldn't IV drugs period.

I quit IV use after 7 years daily and continued my addiction without IV use because I saw some shit happen to other ppl.

But I reserve a special place for if I ever have the fortune to come across dilaided pills for IV use again. No other opioid is worth IV imo. But dilaided IV is the crack of opioids.
 


Warning - the above cartoon deals with injecting drug users and contains strong language and adult themes.

It's worth pausing on that fraction of a second where you see the page of the book and all the questions Mr Mange 'ticks the boxes' for.

I've watched a generation of people I knew all ending up brown bread because they loved the pin.

Yesterday I posted on another one who is now in an isolation unit of the local hospital with multiple infections and who is coughing up blood. I don't know how that story will end but I sense the person knows they aren't likely to leave that room upright.
 
IV Heroin (20+ years ago when it was ACTUALLY decent Diacetylmorphine) light beige tan HCL salts with a pungent pickle like odour of Acetic anhydride (used to convert morphine base into Diacetylmorphine (Heroin). Like opening a bag of salt N vinegar chips…..that potent vinegar odour of decent Heroin was unmistakable

$200 CDN for a street gram of H (roughly a 0.8) but the quality made up for it…..slammed once in an ESSO parking lot and woke up over an hour later with the cigarette burned down to my fingers, drooling head tilted to the side, people walking in to pay for gas….looking at me with disgust …..so embarrassing and shameful.

But THAT was real Heroin…..as real as it gets in Toronto, Ontario Canada 🇨🇦

Now….getting H now is trash especially in B.C. Canada with all those commie fucks in China, synthesizing Fentanyl which is dirt cheap, insainly potent junk to slam thinking it’s H ….how sad

Pharmaceutical Hydromorphone (Dilaudid) 2/4/8mg IR tablets
Oxycodone (Oxy-IR 5/10/20mg)
Methadone 25mg tablets (100 tablet sealed factory bottle monthly) those 40mg METHADOSE 1/4 scored tablets would be ideal

Swiss manufactured Diaphin 10 gram glass jar (10,000mg of pure Diacetylmorphine HCL) F me silly
Dilaudid HP FORT 250mg Lypolized powder for compounding
Sandoz Pharma Hydromorphone HP FORT 10ml small glass vial (100mg / per ml) 1,000mg of HM insaine

Ritalin (Methylphenidate)
Preludin (Phenmetrazine)
Biphetamine (Adderall-mixed Amph salts)
Dexedrine (d-Amphetamine)
Methedrine/Desoxyn (d-Methamphetamine)
Dexamyl (d-Amph + Barbiturates)
Desbutal (d-Meth + Barbiturates)

Valium, Xanax, Ativan, Klonopin
Lyrica, GHB, MDMA, DMT, LSD, Psilocybin
Mephedrone - 4-MMC
Cocaine HCL CII (25 gram jar) “light fluffy crystals”
 
I quit IV use after 7 years daily and continued my addiction without IV use because I saw some shit happen to other ppl.

But I reserve a special place for if I ever have the fortune to come across dilaided pills for IV use again. No other opioid is worth IV imo. But dilaided IV is the crack of opioids.
This is the way!

Dilaudid might be the only drug I could understand people shooting, since it's oral & intranasal bioavailability is crappy.

I'm not giving myself heart damage or losing an arm over just any fricken drug tho.

People who shoot have some heavy fuckin' addiction to the needle itself. Enough to convince themselves that shooting a drug makes it "so much different", and therefore they're "so much cooler & more experienced" because they shoot & because it's "so much better", there just can't possibly be any other way to enjoy that drug. Bullshit. When a drug enters your brain, it's still the same damn drug no matter how it ended up there.

I get "rushes" from opioids & other drugs, even if I snort them or even take them orally. A rush is described as a sudden flood of feelings/effects from the drug.. Well that happens to me when I take a drug through any ROA. But it just takes longer for it to come on or happen when taken non-IV. So what? Learn to be patient with your drug & you'll start to learn more patience/discipline with drugs in general (this is directed at anyone who's still shooting & reading, not you LucidSDreamr lol).

I met some one recently who I have a big crush on & really care about. But he shoots fuckin' meth. And it pisses me off. Cause I know how hard it's gonna be to try & convince him to quit, but I want him to before he ends up accidentally killing himself whether through endocarditis or from something dirty in the fuckin' shit he uses. So yeah I'm a little cranky over this topic today. lol Anyone new to heroin or any drug for that matter should not & would not ever have to switch to IV route to be able to feel the wonderous effects of that drug. I mean, I got hooked on tramadol from 2008-2019. And tramadol has to be taken orally. You can't even shoot tramadol. But it still gave me enough highs, rushes, euphoria, etc.. to keep me hopelessly hooked on it for over a decade. And that was just tramadol (a drug most people hate). Heroin is just fine used through the nose IMO. I use to get heroin & was never once really tempted to shoot it. Plus the high most likely lasts a little bit longer than IV anyway. I think people who love shooting shit are also using drugs for SELF DESTRUCTIVE reasons & not for reasons like "improving quality of life" like I use them for.

I once considered trying to shoot buprenorphine because I thought it might be "different" and "better", except I talked to many people on here first who have done it & every single one told me it's not worth it & that it feels like taking it any other way except it just comes on a little faster. So I decided it wasn't worth it. Sounds exactly like what I imagined it to be. Faster onset, but still the same damn feelings/effects you can get through any other ROA. Faster onset is not worth all the potential complications. And it certainly doesn't always mean the drug will be "better" either. But if you're a needle fanatic, you could probably convince yourself that shooting up water gives you a "rush".
 
Last edited:
This is the way!

Dilaudid might be the only drug I could understand people shooting, since it's oral & intranasal bioavailability is crappy.

I'm not giving myself heart damage or losing an arm over just any fricken drug tho.

People who shoot have some heavy fuckin' addiction to the needle itself. Enough to convince themselves that shooting a drug makes it "so much different", and therefore they're "so much cooler & more experienced" because they shoot & because it's "so much better", there just can't possibly be any other way to enjoy that drug. Bullshit. When a drug enters your brain, it's still the same damn drug no matter how it ended up there.

I get "rushes" from opioids & other drugs, even if I snort them or even take them orally. A rush is described as a sudden flood of feelings/effects from the drug.. Well that happens to me when I take a drug through any ROA. But it just takes longer for it to come on or happen when taken non-IV. So what? Learn to be patient with your drug & you'll start to learn more patience/discipline with drugs in general (this is directed at anyone who's still shooting & reading, not you LucidSDreamr lol).

I met some one recently who I have a big crush on & really care about. But he shoots fuckin' meth. And it pisses me off. Cause I know how hard it's gonna be to try & convince him to quit, but I want him to before he ends up accidentally killing himself whether through endocarditis or from something dirty in the fuckin' shit he uses. So yeah I'm a little cranky over this topic today. lol Anyone new to heroin or any drug for that matter should not & would not ever have to switch to IV route to be able to feel the wonderous effects of that drug. I mean, I got hooked on tramadol from 2008-2019. And tramadol has to be taken orally. You can't even shoot tramadol. But it still gave me enough highs, rushes, euphoria, etc.. to keep me hopelessly hooked on it for over a decade. And that was just tramadol (a drug most people hate). Heroin is just fine used through the nose IMO. I use to get heroin & was never once really tempted to shoot it. Plus the high most likely lasts a little bit longer than IV anyway. I think people who love shooting shit are also using drugs for SELF DESTRUCTIVE reasons & not for reasons like "improving quality of life" like I use them for.

I once considered trying to shoot buprenorphine because I thought it might be "different" and "better", except I talked to many people on here first who have done it & every single one told me it's not worth it & that it feels like taking it any other way except it just comes on a little faster. So I decided it wasn't worth it. Sounds exactly like what I imagined it to be. Faster onset, but still the same damn feelings/effects you can get through any other ROA. Faster onset is not worth all the potential complications. And it certainly doesn't always mean the drug will be "better" either. But if you're a needle fanatic, you could probably convince yourself that shooting up water gives you a "rush".
Not really on Topic but Tramadol got me hooked first as well. It's likely an enzyme variant that makes it hit better or worse for different people
 
I used to IV my heroin because it did feel that much better, but I realized that it really was another whole addiction and another level of stigma.

The whole ritual can be extremely triggering so warning don’t read further if you don’t wish to become triggered.

The fact that it required so many steps and had to be done in a precise manner with steady hands no less, it truly is a skill. Yes nurses and doctors are the professionals who are allowed to do it, but anyone can learn with enough practice and there was a perverted sense of internal pride being able to hit a vein and register almost like a form of meditation with your own body and circulatory system. It requires ideally a private location where one can focus and is free from distractions and other company, so it shares that with private meditation and prayer, one often has to restort to a bathroom unfortunately.

Shooting tar made IV impossible within one year for me. I was used to shooting ECP and didn’t micron filter.

About the same time I got heavily into smoking fentanyl and tar in bongs by dabbing it. I would say the only positive about street fentanyl was that it made it easy to quit the needle because smoking it was so effective.

It was incredibly hard for me to quit the needle. You could even say that in order for me to quit the needle I had to pick up using fentanyl.

A forced detox thru suboxone taper at a rehab was the only way I was able to quit fentanyl along with a geographic relocation. I have used it on isolated ocassions via online order but for the most part not having IRL dealers was the best deterrent. I still order heroin and oxy to supplement my methadone maintenance which isn’t tolerable everyday due to the side effects but officially that’s what I am supposed to be doing.

I have had isolated IV doses but only through other people and only when I don’t watch it register. That’s crucial.

If I start watching it register I know that it would be all over. It’s such a turn on I almost consider it sexy and feel like I could even get a hard on from watching a rig register in my vein. Sick mind, huh?

It took pretty much all of my energy and was very difficult for me to put down the needle like I said I basically did it until I couldn’t anymore and because I was so in love with the process and the rush I had to smoke fentanyl out of a bong in order to stop which is quite the price to pay.

If anyone reading this is considering IVing their drugs know that there is no way of knowing if you will be so unfortunate as to fall as deeply in love with it as I did. Because I sometimes I’m talking like once or twice a year might get a friend to hit me you also could argue that I haven’t even been able to shake it entirely.

The stigma is very real. It doesn’t matter what goes inside the rig, people will never look at you the same if they find out either, only exception might be for diabetics, but even still people notice and people will always remember you almost always in a negative manner once they realize you’re shooting anything be it hard street drugs or something like insulin. Hell I even judged others when I was doing it daily.
 
Snorting heroin was just fine for me.

After couple home overdoses tho it was so much heroin in the syringe. Super saturated solution is I think the word.

But yeah. Never switched for the oral to the hypodermic. Fuck that. Rather quit.
 
I can't speak of ANY non-prescribed medication delivered via the IV route.

But in the UK we still use diamorphine hydrochloride medically. What is interesting is that the few people I know who obtained and jacked up the pure stuff all said how 'subtle' and how 'clinical' it was. It's certainly the case that dry-amps of diamorphine do occassionally turn up on the street and I've noted that they fetch less that one might imagine. A 50mg dry amp would sell for £6-£7 while a £10 bag of H which they all seemed to agree was about as potent is just that. £10.

So IS it the diamorphine or is it the mixture of related compounds that are key to the euphoria. Typically as well as diacetyl morphine, samples will contain morphine, 3-monoacetyl morphine and 6-monoacetyl morphine. In fact, I've read that the last one in that list is MORE potent than H - faster-acting as well.
 
Top