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Opioids Interesting experiment regarding bupe/natrexone affinity competition

M

Magickduck

Bluelighter
Joined
Oct 16, 2012
Messages
405
I am currently participating in a clinical trial for what is essentially a generic version of Suboxone, buperenorphine 6mg/naloxone 1 mg. Because they are testing this on healthy people, they are dosing us with naltrexone first. What I am curious of is whether or not we will still get high. They dosed us with 50mg naltrexone yesterday morning, 50mg naltrexone last night, 50mg naltrexone this morning, 1 hr before the bupe. I have no opioid tolerence and from my research, bupe has a much higher affinity for the mu receptors than naltrexone, so it should overpower it and take over the receptor and we should still get high, right?

However perhaps that is the reason for the frequent and high dosage of naltrexone which has a long half life.

Well we shall see.
 
Update in case anyone cares: The naltrexone has blocked almost or possibly all of the effects of the bupe. 4 hours later and nothing.
 
Magickduck said:
Update in case anyone cares: The naltrexone has blocked almost or possibly all of the effects of the bupe. 4 hours later and nothing.
Click to expand...

wtf i thought bupe had a higher binding affinity? Or is naloxone different than naltrexone and the trex actually DOES have a higher binding affinity than bupe? Damn dude that sucks tho ahahahahaha i woulda loved to have gotten high for a clinical fuckin study!
 
dirzted said:
wtf i thought bupe had a higher binding affinity? Or is naloxone different than naltrexone and the trex actually DOES have a higher binding affinity than bupe? Damn dude that sucks tho ahahahahaha i woulda loved to have gotten high for a clinical fuckin study!
Click to expand...

naloxone is different than naltrexone but bupe also has a higher affinity than naltrexone from all my research but i guess the dose was high enough to overpower it I guess...
 
Yeah, even if one thing has a higher affinity than another thing, dose plays a big role in it...That's why the amount of naloxone required to reverse an overdose varies depending on how much heroin was used..and that was a lot of naltrexone.
 
Later in the day I started to get kinda manic and euphoric then at night they dosed us with naltrexone and now I woke up today depressed
 
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