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Dissociatives [Interaction Subthread] DXM & Medication / Supplements

delta_9 said:
but dxm's not your typical dissociative....in fact, structurally, it's an opiate too.
I'd be careful with dxm opiate combos, you run the risk of respiratory failure and that's no fun :|.
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"DXM doesn't bind at any opiate receptors, doesn't have opiate painkilling effects, and isn't cross-tolerant with opiates."

According to the Dextroverse
 
I don't know this for a fact but I think it's implicated that these non-drowsy prescription antihistamines exert a more potent effect on your histamine physiology and it is mentioned anticholinergic adverse reactions can be expected from the combination.
Doing a risky thing a multitude of times and getting away with it doesn't make it any less risky. Don't confuse the absence of evidence or experience with evidence of absence.
The guy that made this FAQ knows a thing or two about DXM and while he may not be omniscient do not presume you can hold any fact against him from the inscrutability of a bold typed warning - for petes sake. and moreover your own.

in other words: i wouldnt try it again, and drugs.com is honestly not as credible or complete as the name suggests.
 
most DXM-related deaths are caused by a combination of antihistamine + DXM, via Coricidin tabs (which contain chlorphenamine maleate). nobody seems to know exactly how the two interact, but it has been proven to be an unpredictable and deadly combo. that's where the concern stems from i would guess.

your best bet is probably to just skip your Allegra dose on days you wanna trip on DXM. if you want to report your experience / compare to others, you could join 'dextroverse.org' and discuss. the members there will have the best anecdotal info about combinations etc.
 
Howdy.

So this does confirm my current research. It seems the Non-Drowsy anti-histamines could be more of a potential aggressor with the DXM.

If I were you, I would skip the day you plan on dexing, or possibly skip a couple days in advance and switch it out with Benadryl or something.

The Benadryl (Diphenhydramine) is fine with DXM, and i've had my friends use it without any issues. This one IS a drowsy anti-histamine, and is the active in most OTC sleep meds. However I find the Dex will offset that pretty well.

Allegra says its fully absorbed into the bloodstream within 2.5 hours, so I would imagine if you skipped a day you'd probably be pretty well set by the night time you dex up.
 
I got conflicting information on the detroverse site. I guess apparently you shouldnt take it 6 weeks before hand before you take DXM. But thats why too long. I took some allegra today but might do some DXM later.

What would you say about mixing 4-6oz of robo plus like 30mg of hydrocodone?
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Did it once by accident and once I realized how much I was enjoying it, I ramped it up to a good second plateau with 10mg hydrocodone, another 5mg two hours later and then another 10mg two hours after that. I personally enjoyed it save the itching and moderate to intense nausea.

Is it safe? I don't know.
 
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Sorry to dig up an old grave, but I have a query about certain Antihistamines and DXM:

Promethazine - Want to use it for nausea. Any potential problems there?
Chlorphenamine /Chlorpheniramine - Would be ideal for itching, but it does act as an SNRI also.
Diphenhydramine - The same as above, but with the small difference of being an SSRI.

The above 2 could be interchanged with Cetirizine if needed as I don't think there'd be any danger with that.

Cheers :)

p.s. I might have to bump this a few times as it's old, it's the last page and in circumstances like this, questions sometimes tend to get overlooked.
 
I'll give it a
bump.gif

now.
 
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OMG its the old me! :D LOL! I don't even remember making this...brain damage. I'll research these questions from a few intelligent sites that aren't wiki or erowid and try to get back soon as possible.

***Damn, look at all those posts I had and the longevity of membership. I signed onto this site back when it was bluelight.nu when it changed to bluelight.ru I had forgot my password and old e-mail by then. 8o
 
Have you taken DXM with mirtazapine (Remeron)?

Hello,

Who here has taken DXM in conjunction with mirtazapine? Did you notice any difference in the quality of the trip? Was is more intense? Less intense? No difference? Were you more burned-out than usual the next day?

I ask because mirtazapine strongly antagonizes the 5-HT2A receptor in the brain. 5-HT2A receptor agonists prevent NMDA antagonist neurotoxicity. If such an action can prevent neurotoxicity, I wonder if the reverse can induce neurotoxity where it might not have occurred otherwise?

I posted my question to ADD, but got no replies from the people there. So I'm asking for subjective experiences instead :\

I myself have taken DXM only four times without mirtazapine. Foolish? Maybe. My daily intake of mirtazapine might account for my sensitivity to DXM, since they are both metabolized by the same enzyme, and since 5-HT2A agonists are theorized to inhibit the hallucinatory effects of dissociatives. A 5-HT2A antagonist might therefore increase the psychedelic effects.

So what are your experiences with this combo? Even if you have taken mirtazapine the day before your DXM trip, I would still like to hear about it!

~mec~
 
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Here's our Antidepressant and Recreational drugs FAQ in the Healthy Living forum.

Here's a good snippet:

Mirtazapine
Mechanism of Action
Mirtazapine is an antagonist of presynaptic alpha 2-adrenergic autoreceptors and heteroreceptors on both norepinephrine and serotonin presynaptic axons. It is also is a potent antagonist of 5HT2 and 5HT3 receptors. As a result, there is increased NE and 5HT activity, especially increased 5HT activitity at the 5HT1A receptors.
Common Side Effects
Sedation, increased appetite, dizziness, and weight gain.
Metabolism
CYP2D6, CYP1A2, and CYP3A4 are the primary enzymes involved in the metabolism of mirtazapine.
Recreational Drug Interactions
Alcohol, Benzos (Xanax, Valium, Klonopin etc), Opiates (Heroin, Codeine, Vicoden, Oxy etc), Barbituates, Ketamine: The effects of these drugs will be stronger than normal, as they will add to the sedative effects of mirtazapine. CAREFUL and go easy on these drugs and stick to low doses until you are sure how they interact with the mirtazapine.
DXM (Dextremethorphan, Robotussin): Because mirtazapine and DXM are metabolized by some of the same enzymes, this combination is most likely quite dangerous. Avoid taking DXM and mirtazapine together!
MDMA/Ecstasy (includes MDA, MDEA etc): Rolling on mirtazapine is relatively safe. Some people find that they do not roll quite as hard as they usually would, and that they need to take about 1/2 an extra pill to obtain normal effects.
Amphetamines (Methamphetamine, Adderall, Dexedrine), Ritalin (methylphenidate), Cocaine: Using stimulants while on mirtazapine seems to be relatively safe as well. The mirtazapine does not appear to affect the recreational effects of the stimulant (i.e. you will get just as high as you always did).
Hallucinogens (LSD/Acid, psilocybin/Shrooms, Tryptamines – 2-ct-2,DPT, DMT etc, Salvia) Hallucinogens seem to be MUCH stronger in combination with mirtazapine, so please be VERY CAREFUL! A dangerous interaction with shrooms has been observed in one person taking mirtazapine. Please avoid hallucinogens while taking mirtazapine or dose very carefully.
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Take that for what you will, it was written a long time ago. Might want to find more info.
 
Yeah, I have already read through this and other articles. I usually always research a topic before asking questions ;)

I wanted some personal experience reports from people who had actually taken this combo. A few reports turned up here on Bluelight. There are very few reports to be found on the web.
 
There is still a risk for serotonin syndrome since mirtazapine indirectly agonizes the 5-HT1A receptor. Google the words: serotonin syndrome mirtazapine tramadol.

I know you aren't planning on taking tramadol but it's the same concept as it increases the flow of serotonin.
 
You're right. It looks like there is a real risk for developing SS with this combo, so I'll definitely take a break from the mirtazapine before embarking on my next journey. Mirtazapine has a half-life of 20-40 hours, so two days off might be called for. That probably means no melatonin aalso, since it converts to serotonin eventually. Thanks!
 
Claritin and DXM

I've done some searching, but really can't come up with a solid answer.

Why is the combo of claritin and dxm risky? Is this risk real? Or is it more just a risk if you take high dosages of claritin and high dosages of DXM you'll run into problems?

I'm not looking to take high dosages of DXM, prob go for a moderate trip, and I take claritin most days, usually 10mg. I did have a heart scare a few years ago but it turned out to be nothing (they think). So I try to be careful.
 
both drugs are metabolized primarily by the cytochrome P450 enzymes CYP3A4 and CYP2D6. Therefore, loratadine inhibits the breakdown of DXM, and vica versa. Presumably, this would increase the effects and durations of both drugs, and increase the risk and severity of possible adverse effects.

maybe just skip the Claritin a day or two before tripping?

http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=39741

http://en.wikipedia.org/wiki/Dextromethorphan#Metabolism
 
i also take claritin some days, but am scared it might react with dxm

how many days do i need to wait after i take claritin until i can safely trip?
 
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