In times of no Cannabis

[Esperighanto]

There's been some discussions on possible Dagga actives. Possible GABA / Adenosine / glutamte NMDA stuff going on?

Leonurine - Wikipedia

en.wikipedia.org

https://www.mdpi.com/2218-0532/91/3/41

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Thread 'Another theory on wild dagga pharmacology'

Oct 1, 2014

I've been poking around, and I dont have much time but I found quite a few studies on Wild dagga(leonotus Leonurus) itself, and one if it's diterpenoids: Marrubiin.
So, here we can see that Wild Dagga can block convulsions caused by both NMDA and assorted GABA antagonists: http://www.ncbi.nlm.nih.gov/pubmed/12046862

However, it seems apparent that whatever is binding to GABA does not have a higher affinity than Bicuculine.
Here we see the analgesic properties of Marrubiin: http://www.ncbi.nlm.nih.gov/pubmed/10839213

This study suggests that analgesia is not due to mu-opioid...

• DL-ark
• Replies: 8
• Forum: Neuroscience and Pharmacology Discussion

• 

I've never found solid papers on dagga pharmacology, but I have used quite a bit of it and it's interesting, but it feels unlike anything I've ever touched. Closest to cannabis, but it surely does not feel like a cannabinoid to me. Might be though, you can never really tell until you get the studies in.