• H&R Moderators: VerbalTruist

I'ld like to hear from anyone who uses an opioid to fight depression.

Dealt with depression for decades. Only time I ever had a medication free me from the black hole was when I had spinal surgery. At first I thought it was just relieving my pain. Over awhile afterwards I was in pain management.

15mg of oxycodone worked better for my depression than anything in 20 years. Obviously I couldn’t take long term as Oxy basically destroys your testosterone levels and then you’re back in same depressed low energy mode.

I’m convinced that Pharma could cure depression with some kind of derivative of opioids if they saw fit. Instead they just continue with these garbage SSRI’s or whatever other useless crap they have. Obviously there’s no $$$ in curing disease but I would think this kind of medication would have to be taken for long periods. Just comes down to the fact that we live in hell.

They’d probably prefer we give up. I’ve been off Oxy for years but wish I had it on days when I can’t even get out of bed or function normally.
would the opioid be taken for a shorter period of time than the SSRI?

many people discontinue SSRIs after a year or two after adaptations take place

is the opioid a cure?
 
Methadone helps but I suspect it's the NMDA-antagonism that is responsible. Pure opiod receptor agonist seems effective only against anxiety in the long run aka when the honeymoon is over and the euphoria is gone.
 
Dealt with depression for decades. Only time I ever had a medication free me from the black hole was when I had spinal surgery. At first I thought it was just relieving my pain. Over awhile afterwards I was in pain management.

15mg of oxycodone worked better for my depression than anything in 20 years. Obviously I couldn’t take long term as Oxy basically destroys your testosterone levels and then you’re back in same depressed low energy mode.

I’m convinced that Pharma could cure depression with some kind of derivative of opioids if they saw fit. Instead they just continue with these garbage SSRI’s or whatever other useless crap they have. Obviously there’s no $$$ in curing disease but I would think this kind of medication would have to be taken for long periods. Just comes down to the fact that we live in hell.

They’d probably prefer we give up. I’ve been off Oxy for years but wish I had it on days when I can’t even get out of bed or function normally.

There currently is an opioid that big pharma has marketed to treat depression - Ketamine. I guess some find it helpful, but it's no cure. (Ask Elon Musk.) Depression is like cancer, in that the causes are multiple and complex. I don't believe there will ever be a silver bullet that fixes either of those diseases. It's my belief that a lot of depression comes from lack of social connection. It's unlikely, in my mind, that there will ever be a pharmaceutical fix for depression that restores most depressives to normal functioning and mood elevation.

I guess I/V heroin can make a person feel real good for a while. That's why people fall in love with it. As we know, that good feeling comes at an awful price that, eventually, backfires terribly.
 
I would say I definitely do , I take methodone but I've had crazy anxiety panic attacks lately and it has done nothing for it so I would say after a minute of being on opiates it has less. Effect on depression. I had to buy Kolonipin and Xanax for a bit until my SSRI kicked in luckily I have month long take homes
 
I would say I definitely do , I take methodone but I've had crazy anxiety panic attacks lately and it has done nothing for it so I would say after a minute of being on opiates it has less. Effect on depression. I had to buy Kolonipin and Xanax for a bit until my SSRI kicked in luckily I have month long take homes

I'm sorry you're dealing with anxiety. My main problem is depression, but I get anxiety now and then. I think bad anxiety is worse than depression. The Xanax can be a help in calming the anxiety. Klonipin and Xanax are benzodiazepines. Benzos are addictive. You build tolerance, so the drug becomes less effective. Eventually, you're taking the benzo just to avoid withdrawal. But, short term, it can help get you through a rough period. I hope you figure out what is needed to help you manage the anxiety.
 
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